Novel piperazinoamide compound

A compound, selected technology, applied in organic chemistry, drug combination, cardiovascular system diseases, etc.

Active Publication Date: 2010-10-06
GUANGZHOU INST OF BIOMEDICINE & HEALTH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Formula I

Method used

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  • Novel piperazinoamide compound
  • Novel piperazinoamide compound
  • Novel piperazinoamide compound

Examples

Experimental program
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Embodiment 13

Embodiment 23

Embodiment 3

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Abstract

The invention relates to a novel piperazinoamide compound, a preparation method thereof, and application thereof in treating neurodegenerative disease, mental disease, epilepsy, convulsion, apoplexy, and the like. The structure of the piperazinoamide compound is shown as formula I. The in vitro tests verify that the piperazinoamide compound has an effect of inhibiting cells BV2 from secreting IL-1beta effectively, and has high safety. The formula I is shown in the description.

Description

technical field The present invention relates to a novel piperazine amide compound, a preparation method thereof, a composition containing the substance, and the compound as a neuroinflammation inhibitor to treat or prevent neurodegenerative diseases, such as Alzheimer's disease and Parkinson's The use of antipsychotic, antiepileptic, anticonvulsant and antistroke diseases. Background technique Alzheimer's disease, also known as Alzheimer's disease (Alzheimer's disease, AD), is a central nervous system degenerative disease mainly characterized by progressive cognitive impairment and memory impairment. The clinical manifestations of the disease are short-term memory dysfunction, followed by persistent mental decline, loss of judgment and reasoning ability, aphasia, and movement disorders. Its pathological features are a large number of senile plaques (SPs) and neurofibrillary tangles (neurofibrilary tangles, NFTs). There are two main types of drugs currently on the market: ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D237/24C07D403/12C07D401/12C07D239/72C07D207/34C07D333/38C07D231/56C07D231/14A61K31/501A61K31/506A61K31/517A61K31/496A61P25/28A61P25/18A61P25/08A61P9/10A61P25/16
Inventor 胡文辉钟桂发曾少高杨玲徐宏江
Owner GUANGZHOU INST OF BIOMEDICINE & HEALTH CHINESE ACAD OF SCI
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