188results about How to "Has anticancer effect" patented technology

The invention relates to a biological fermentation composition with an anti-cancer effect. The biological fermentation composition is prepared by using a method comprising the following steps: a, preparing a culture medium mixed solution; b, sterilizing; c, cooling; d, inoculating to obtain a fermentation solution; and e, standing to obtain the biological fermentation composition with the anti-cancer effect. The composition disclosed by the invention can be used for improving the in-vivo micro-ecological environment, balancing and regulating effective microbial communities in intestinal canals, repairing damaged cells, replenishing various in-vivo active bio-enzymes, amino acids, nucleic acids, trace elements and the like, improving the immunity of a human body, preventing diseases, effectively inhibiting cancer cells and stopping the dispersion and development of the cancer cells. Meanwhile, the biological fermentation composition can be used for improving an acidic physique to be a weak alkaline physique, is particularly suitable for the cancer crowd, the crowd with hypertension, hyperlipidemia and hyperglycemia and the fat crowd, can be prepared into various dosage forms such as pills, paste, aqueous solutions and the like, and has favorable supportive therapeutic effects on cancer, diabetes, digestive system diseases and the like.

The invention provides an isinglass empty capsule, aiming to meet the requirements for drug intake of special crowds and to adapt to the development need of the market. The isinglass empty capsule adopts the technical scheme that the isinglass empty capsule comprises the following components in percentage by weight: 82.5-87.5% of isinglass, 0.1-2.0% of gelata, 0.04-0.4% of gelatin additive, 0.05-0.25% of plasticizer, 0.001-0.02% of release agent, 0.00-0.002% of coloring agent, and the balance of water. The isinglass empty capsule is the potential need of gelatin market as well as the need forproviding high-quality gelatin empty capsules, and can increase the usage of isinglass at the same time.

The present invention relates to nutrition honey and the preparation method, in particular to a compound of blueberry and honey which has a nutritional and health promoting effect and a preparation method. The compound disclosed by the present invention contains 0.02-10.0percent of fine powders or super powders of blueberry fruits, leaves, stems, roots and flowers or a mixture of one or a plurality of kinds of extracts of the raw materials and 90.0-99.98percent of honey. The present invention also discloses the preparation method of the compound, which is that the fine powders or super powders of blueberry fruits, leaves, stems, roots and flowers or the mixture of one or a plurality of kinds of extracts of the raw materials are added in the honeys. The honeys, the blueberry powders or the extracts are mixed evenly by a mixing machine. Effective components of the blueberries can be absorbed in human bodies during a honey took process. The trouble of taking blueberries alone can be reduced, the simulation on the human bodies can be released, and at the same time, the health function of the honeys is enhanced.

The invention discloses a selfheal polysaccharide zinc chelate as well as a preparation method and application thereof to an anti-cancer drug. The method comprises the following steps: crushing selfheal clusters, decolorizing by use of ethanol, adding distilled water, performing reflux extraction, deproteinizing the extracting solution, performing ultrafiltration, and freeze-drying the retained liquid to obtain polysaccharide; preparing a polysaccharide solution of which the concentration is 10 mg / mL to 40 mg / mL, heating to the temperature of 40-60 DEG C, regulating pH by using sodium hydroxide, slowly adding a zinc salt solution into the polysaccharide solution, reacting for 6-24 hours, simultaneously performing an discontinuous homogenization process by using a high-shear homogenizer, regulating the pH by using hydrochloric acid, centrifuging to obtain supernatant liquor, putting the supernatant liquor into a dialysis bag for dialysis, collecting the solution in the dialysis bag, and performing freeze-drying to obtain the selfheal polysaccharide zinc chelate. The product disclosed by the invention is simple and easy to implement in preparation method, has a remarkable anti-proliferation effect on human cancer cells and also causes no cytotoxicity to normal cells of the human body, so the selfheal polysaccharide zinc chelate is an ideal anti-cancer drug or a health care product and also has a zinc replenishment effect.

The invention discloses a beverage for reducing blood sugar, blood pressure and blood fat, which comprises the following dry materials in part by weight: 3 to 6 parts of bitter gourd, 3 to 6 parts of corn stigma, 2 to 4 parts of raw astragalus, 2 to 4 parts of yam, 2 to 4 parts of Siberian solomonseal rhizome, 5 to 10 parts of bitter buckwheat husk and 100 parts of water. A production method of the beverage comprises the following steps of: cutting the raw materials into small pieces according to the proportion, putting into a ceramic container, adding the water, decocting for two or three times, mixing filtrate, adding an appropriate amount of flavoring agent, and sterilizing to obtain a finished product. The beverage prepared through reasonable compatibility of six natural raw materials is lukewarm in nature, has obvious curative effects on most of patients with hyperglycemia, hypertension and hyperlipidemia, cannot harm intestines and stomach after being drunk, and has a certain health-care effect; and the production process is simple, and the product is convenient to drink.

The invention relates to the Yew genus plant extract and its extraction method and application, wherein the extract is extracted from the stems and leaves of Northeastern yew and comprises taxone diterpenoid, total lignans, total flavone. The extract can be used as the effective composition for anti-cancer drugs.

The invention discloses an inulin soya-bean milk beverage and a preparation method thereof, belonging to the technical field of food processing. The inulin soya-bean milk beverage disclosed by the invention mainly consists of the following components in parts by weight: 80-120 parts of soya-bean milk, 2-20 parts of inulin, 1-5 parts of honey and 0.1-0.4 parts of a stabilizer, wherein the inulin, which is also called as synanthrin, is linear straight-chain polysaccharide formed by D-fructose through key jointing of beta (1 to 2), the tail end of the inulin is provided with a glucose residue, and the degree of polymerization is 2-60. The inulin, as a soluble dietary fiber different from a starch structure, can selectively promote the growth of colon probiotics and improve the health condition of a host. The inulin soya-bean milk beverage disclosed by the invention is white, is exquisite and smooth in mouth feel, has a low caloric value and can promote the growth of human colon probiotics, inhibit toxic fermentation products, promote the absorption of mineral materials such as calcium, magnesium and iron and improve the physiological functions such as immunity of the organism.

The invention belongs to the field of genetic engineering, in particular to the application of miR-451 in preparing a medicine for treating non-small cell lung cancer. Since the recombinant of Pre-miR-451 has influence on propagation, apoptosis, migration and drug resistance of non-small cell lung cancer cells, it is proved that the miR-451 prohibits the propagation, migration and drug resistance of the non-small cell lung cancer cells and promotes the apoptosis of the non-small cell lung cancer cells; and living body level also indicates that the miR-451 has excellent anti-cancer effect.

The invention relates to complex paclitaxel and its derivates docetaxel intralipid which includes the following ingredients: paclitaxel or docetaxel, vegetable oil, solubilizing agent, lecithin, glycerine, and water for injection at a ratio of 0.5-10:10-100:10-100:10-20:20-25:700-950. The preparing method includes the following steps: stirring with high speed homogenating machine or ultrasonic oscillating to get the protogala; preparing the complex paclitaxel intralipid with high pressure homogenizer. The preparation is intralipid in O / W type which packages paclitaxel or docetaxel into the compound oil phase. The compound oil phase has good solubility for paclitaxel or docetaxel which has prevented the phenomenon of precipitation after diluting the emulsion; the ingredients of compound oil has the function of coordinated antitumous effect; it can also release the injecting irritative response, haemolysis and hypersensitiveness; it has the function of targeting which has increased the drug action.

The invention provides a Chinese medicinal preparatoin for treating hepatic fibrosis and hepatic cirrhosis, which is prepared from Cordyceps sinensis, peach kernels, root of red rooted saliva, astragalus root through processing into the powdery form and pills.

The invention discloses a new drug against lung cancer and an extraction separation method of the new drug. The extraction separation method comprises the following steps of: performing homogenate, 70% alcohol extraction, deproteinization by trichloroacetic acid and vacuum freeze-drying on whole mollusk Vaginulus alteFerussac, performing chromatographic separation by gel columns repeatedly for multiple times, detecting molecular weight, molecular organization and primary molecular structures of the components, and conducting in-vivo and vitro anticancer pharmacology experiments to obtain an anti-lung-cancer active ingredient JK of the Vaginulus alteFerussac. Animal experiments prove that the heavy inhibition ratio of the JK on human-derived lung adenocarcinoma A549 cytoma reaches 54.37%; the heavy inhibition ratio of the JK on human-derived small cell lung cancer CNI-H446 cytoma reaches 59.73%; the heavy inhibition ratio of the JK on rat-derived Lewis lung cancer tumor reaches 49.49%; and the combination of the JK and cinobufotalin generates a synergistic effect. The experiments also prove that the JK has anticancer mechanisms shared by multiple Chinese traditional medicines, is compound with multiple target points, and relates to the synthesis of nucleic acid for inhibiting lung cancer cells, induction of lung cancer apoptosis, angiogenesis for restraining lung cancer tissue and the adhesion of the cancer cells on a vascular wall after the cancer cells invade blood circulation.

The invention discloses application of an ursolic acid conjugate having the anticancer activity and serving as a drug carrier or a molecular probe carrier. The ursolic acid conjugate is characterized by being a conjugate formed by connecting of carboxy groups of ursolic acid or derivatives of ursolic acid with amino groups of guanidine drugs in the form of amido bonds. According to the specific application, a drug or a molecular probe is encapsulated and carried with the ursolic acid conjugate to form nanoparticles. When serving as the carrier, the referred conjugate has a certain anticancer effect without too high cytotoxicity and is easy and convenient to synthesize; the nanoparticles are self-assembled through a solvent exchange method, when the ursolic acid conjugate serves as the carrier of an anticancer drug or a fluorescent material, the problem on water solubility of a series of anticancer drugs is effectively solved.

The invention discloses a series health-care food containing pearl and kudzu root and a preparation method thereof. The food is prepared by matching natural pearl and kudzu root which can be taken both as food and medicine with vitamin, medlar, a sweetening agent and appropriate accessories according to a certain proportion. The health-care food contains organic calcium, inorganic calcium, vitamin and a plurality of trace elements which are needed by human body, and the food further contains components such as flavonoid daidzin, daidzein, xylopuerarin, kudzu powder flavin, and great amount of starch, therefore, the food has the functions of beautifying the face and enlarging the breast, nourishing the tendons and channels and preventing cerebral-cardiovascular diseases, and is taken as health products which are fit for women, the middle aged people and the old, thus delaying senility, strengthening the body and maintaining the beauty and youth of skin.

The invention belongs to the technical field of health foods, and in particular relates to lotus leaf weight-reducing tea. The tea comprises the following components in parts by mass: 25-35 parts of lotus leaf, 15-25 parts of hawthorn, 5-15 parts of mung bean, 15-25 parts of oolong, 10-20 parts of watermelon peel, and 5-10 parts of burdock. The traditional Chinese medicinal weight-reducing tea cannot destroy gastrointestinal digestion, stomach and other body mechanisms of a patient.

A silicon-selenium humate fertilizer is characterized in that: the fertilizer consists of the raw materials with the following weight percentage: 40 to 60 percent of humic acid, 5 to 20 percent of sodium selenite and 20 to 40 percent of silicon micropowder. The humic acid is ammonium humate, potassium humate or sodium humate. The silicon-selenium humate fertilizer, which is widely used in crops such as wheat, corn, soybean, melon, fruit and vegetable, has outstanding effects in improving soil, adjusting soil solution acidity, reinforcing chemical fertilizer fertility and reducing fertilizing cost.

The invention relates to a traditional Chinese medicine for curing hyperplasia of mammary glands, and belongs to a medicament prepared from the traditional Chinese medicine materials based on the preparation method of capsules, powder or pills. The invention mainly solves the technical difficulties that the prior therapeutic method has great side effect on human body, and can not eradicate the diseases. The technical proposal is as follows: according to the preparation method of capsules, powder or pills, the traditional Chinese medicine for curing hyperplasia of mammary glands comprises the following raw materials by weight part: 3 to 5 g of bupleurum, 12 to 18 g of membranous milk vetch root, 4 to 8 g of cowherb seed, 3 to 5 g of pangolin, 2 to 5 g of sweetgum fruit, 2 to 4 g of gleditschia xylocarpa hance, 4 to 8 g of salvia miltiorrhiza, 6 to 10 g of Chinese angelica root, 4 to 8 g of red paeonia, 3 to 5 g of rhizoma sparganii, 3 to 5 g of rhizoma zedoariae, 3 to 5 g of fructus meliae toosendan, 3 to 5 g of fingered citron, 3 to 5 g of bitter orange and 3 to 5 g of fructus psoraleae. The traditional Chinese medicine has the advantages of good curative effect, convenient administration, immediate effect and no toxic or side effect.

The invention discloses a preparation method of sauce with tea flavor, comprising the following steps of: (1) selecting one or more kinds kind from green tea, Pu'er tea, oolong and black tea, soaking and boiling to obtain tea extract; and (2) mixing, boiling, filtering and filling the tea extract together with the concentrated and sun-cured sauce concentrated solution, flavoring agent and essence, to obtain dark soy sauce with tea flavor; or (3) mixing, boiling, filtering and filling the tea extract together with the fermented sauce stock solution, the flavoring agent and the essence to obtain the dark soy sauce with tea flavor. By adopting the preparation method of sauce with tea flavor, the tea extract with health care function is added to the original flavor of the common sauce, and the obtained sauce with tea flavor has the unique flavor of sauce, and the nutrition and health care function of the sauce are enhanced.

The present invention relates to a manufacturing method of a health beverage that can effectively prevent and treat asthma, namely, mix main raw materials such as shredded loofah and pears, shredded snowflakes Cordyceps sinensis, papaya and other auxiliary raw materials with brown sugar, and mix the mixture naturally After fermenting for a certain period of time, filter, and then mix mulberry fungus powder in the extract, which is effective for asthma, cough, phlegm and other diseases. The invention comprises: a mixing step, washing and shredding main raw materials such as loofah, pear, kumquat, radish, bellflower, etc., washing and shredding snowflake Cordyceps sinensis, ginger, papaya, pomegranate, ginkgo, onion, eggplant, orange Fruit, cactus, grapefruit and other auxiliary raw materials, brown sugar is mixed in a weight ratio of 60-70:20-30:10-35; fermentation step, at a temperature of 10-25 ° C, the mixture is naturally fermented for 3-6 months; extraction The step is to filter the fermented mixture and extract the extract; the step of mixing mulberry fungus is to mix 15-25 g of mulberry fungus powder with 1 kg of the extract.

The invention discloses application of adopting an aspirin conjugate with the antitumor activity as a drug carrier or a molecular probe carrier. The aspirin conjugate is the conjugate of aspirin and a hydroxyl-containing pentacyclic triterpenoid or amino-containing anti-cancer drugs. According to the application, nanoparticles are formed for an entrapment drug or molecular probe of the aspirin conjugate. The problem of water solubility of multiple drugs is solved, the conjugate has the antitumor activity and does not have large cytotoxicity when as the carrier, the entrapment drug can achieve the better curative effect, and the entrapment molecular probe can achieve integration of diagnosis and treatment.

The present invention relates to a fermented red ginseng manufacturing method which enhances the content of ginsenoside Rg3 and Rb1 and, more specifically, to a fermented red ginseng manufacturing method which includes the following steps of: (a) preparing a red ginseng; and (b) adding Bacillus velezensis (KACC 91217P) to the prepared red ginseng and fermenting the ginseng. According to the present invention, the method to manufacture a fermented red ginseng reduces the processing time of the fermented red ginseng, and increases the content of ginsenoside Rg3 and Rb1 with excellent effect.

The invention belongs to the field of medical technology, which relates to diarylurea derivatives or salts accepted in medicine shown in formula I, wherein substituents of Ar1, Ar2, X and n have definitions given in an instruction. The derivatives shown in the formula I can be used for preparing receptor protein-tyrosine kinase inhibitor (RPTKI), and medicaments used for treating and / or preventingcancer or other proliferative diseases. The derivatives or salts accepted in medicine can be taken as active ingredients for preparing composition or different preparations used in clinical requirement mixed together with different carriers or excipient in medicine so as to be used for treating and / or preventing from various cancers.

The invention discloses a complex probiotics for curing hypertension and coronary heart disease and a preparation method thereof, the complex probiotics can also be prepared by the following strains according to proportioning by weight: the proportions of Lactobacillus bulgaricus, bifidobacteria and Lactobacillus reuteri are respectively 1-5, 1-4 and 3-7; wherein, the viable contents are all 1.8-2.6 billion / ml. By replenishing probiotics in the invention, the micro-ecological balance of intestinal tracts can be adjusted and meanwhile the change of cholesterol preparation mechanism of human body is triggered, then low density lipoprotein (LDL) in human blood vessel is quickly removed so that thrombus is fast dissolved and new thrombus is difficult to form, thus reaching the aims of curing coronary heart disease and reducing the blood pressure.

The invention discloses a seaweed / okra composite crucian feed. The invention is characterized in that the feed is prepared from the following raw materials in parts by weight: 11-13 parts of silkworm pupa, 12-14 parts of bone meal, 6-9 parts of shell powder, 8-12 parts of cattle manure, 0.3-0.5 part of lactobacillus, 18-23 parts of corn flour, 15-18 parts of pine needle leaf, 16-19 parts of seaweed, 13-15 parts of okra, 3-4 parts of white granulated sugar, 20-25 parts of vegetable pulp, 21-23 parts of linter pulp, 8-10 parts of wheat middling, 2-4 parts of rice bran oil, 1-2 parts of soybean lecithin, 1.2-2.4 parts of bentonite, 3-6 parts of assistant and a right amount of water. By adding the okra, the feed has unique flavor and high nutritive value, and can promote digestion; and by maximally using the vegetable pulp and linter pulp instead of the fish meal, the consumption of the fish meal in the crucian feed is obviously lowered, so the feed can effectively lower the crucian culture cost and has higher cost performance.

The invention discloses a wastewater-free reverse osmosis (RO) water treatment device combining functions of healthy water and purified water, comprising a water feeding device and a water discharging device, wherein a pre-treatment system, an RO membrane, post-positioned active carbon and a water processor are respectively connected between the water feeding device and the water discharging device through pipelines, wherein the downstream of the pre-treatment system is connected with a water feeding solenoid valve and a boosting pump; the boosting pump is connected with the RO membrane and the RO membrane is connected with a concentrated water treatment system. According to the invention, compared with the water with a common water storage barrel condition, hydrogen-rich activated water (the healthy water) provided by the device disclosed by the invention is directly generated and does not have a storage process in a water storage barrel, so that the water is more fresh and the mouth feel is better.

The invention discloses a cobalt selenide nano material and an application thereof. A preparation method for the cobalt selenide nano material comprises the following steps: adding a selenium-containing compound and a cobalt salt into a solvent, and fiercely stirring at a room temperature until uniformly mixing; then, pouring a mixed solution into a reaction kettle, and heating for reacting at 180 DEG C for 10-20 hours to obtain precipitates; centrifuging and washing the obtained precipitates, and adding the centrifuged and washed precipitates into an aqueous solution containing a stabilizer; and performing ultrasonic treatment and stirring to obtain a stabilizer-modified water-soluble cobalt selenide nano material. The preparation method for the cobalt selenide nano material disclosed by the invention is simple and convenient to operate, low in energy consumption and easy for large-scale production. The prepared nano particle is uniform in particle granularity and good in dispersion, can be used as a contrast agent for photoacoustic imaging and magnetic resonance imaging, and has important application prospect in the tumor imaging field.

The invention discloses a riboflavine sodium phosphate composition injection and a preparation method thereof. The riboflavine sodium phosphate composition injection comprises riboflavine sodium phosphate, citric acid, sodium hydroxide and sodium chloride. Each injection contains 5 to 15mg of riboflavine sodium phosphate, 2.1mg of citric acid, 2 to 4mg of sodium hydroxide and 0.6 to 0.8mg of sodium chloride. The preparation method comprises the following steps: adding water used for injection into the citric acid for stirring and dissolving; adjusting the pH to about 6.2 with sodium hydroxide; adding sodium chloride for stirring to dissolve the sodium chloride; adding the water used for injection and 1g of active carbon; adding riboflavine sodium phosphate while stirring; after the riboflavine sodium phosphate is completely dissolved, complementing the water for injection until the total amount is completely complemented; performing filtering, refluxing, filling, nitrogen charge, melting to seal, sterilizing at a high temperature; and after reducing the temperature, detecting with lamps, packing and checking, and obtaining the finished product. The riboflavine sodium phosphate composition injection does not crystallize, has good clarity and stability, and is helpful for improving the yield of the product, reducing the market rick of the product and is better applied to clinical treatment.

The invention discloses a pickling method of a nourishing old goose. A pickling material for pickling the old goose is prepared by boiling 50%-75% of traditional Chinese medicine preparation, 10%-20% of a seasoning preparation and the balance of water, wherein the traditional Chinese medicine preparation comprises the following components in parts by weight: 4-6.5 parts of Chinese magnoliavine fruit, 4.5-5.5 parts of Chinese angelica, 5-7 parts of bulbus fritillaria, 1-1.5 parts of dwarf lilyturf tuber, 1.5-3 parts of dried rehmannia root, 0.8-2 parts of lucid ganoderma, 5.5-7 parts of barbary wolfberry fruit and 1-2 parts of plantain seed. According to the pickling method disclosed by the invention, the old goose pickled by using the formula can ensure the delicious taste and simultaneously greatly improve the nutritional value of food; as the old goose is fully soaked in a halogen material, after a consumer buys the nourishing old goose home, seasoning material is not required, the nourishing old goose can be used for stewing a soup and barbecuing, and the operation is simple.

The invention discloses a chrysin non-natural amino acid derivative or pharmacologically-acceptable hydrate and salt thereof. The chrysin non-natural amino acid derivative comprises a stereoisomer ora tautomer. The chrysin non-natural amino acid derivative comprises the following preparation steps: preparing 5-hydroxy-7-propargylflavone by chrysin and propargyl bromide under the action of alkali;preparing (L / D)-N3-Boc amino acid methyl ester by (L / D)-halogenated-Boc amino acid methyl ester and NaN3 under the action of CuI / L-proline sodium; reacting the 5-hydroxy-7-propargylflavone and the (L / D)-N3-Boc amino acid methyl ester under the action of CuSO4.5H2O / sodium ascorbate, removing Boc groups and hydrolyzing to prepare the chrysin amino acid derivative. The chrysin non-natural amino acidderivative disclosed by the invention has an anti-cancer effect and can be used in preparation of an anti-cancer drug.

The invention discloses a processing method of dried crocodile meat. The method comprises the following steps of raw material selection, raw material cleaning, deodorization treatment, primary pickling treatment, secondary pickling treatment, sterilization treatment, vacuum packaging and the like. The processing method of the dried crocodile meat has the advantages that the crocodile meat is subjected to cleaning, deodorization, pickling, baking and packaging to be made into the dried crocodile meat; the processing work procedure is simple; the defects in the prior art are overcome; the original nutrition and mouthfeel of the crocodile meat are maintained to the maximum degree; the unique flavor is realized; after the crocodile meat is soaked by milk, the fragrance of the milk is realized;seasoning materials use a mixture of table salt, pepper powder, hawthorn powder and radix puerariae powder, so that the prepared dried crocodile meat has the effects of nourishing the stomach, stimulating the appetite and enhancing the appetite; a certain health care effect is also achieved; the method is worthy of being popularized; high pressure and low temperature sterilization and UV irradiation sterilization are used; the sterilization effect is good; the packaging environment is aseptic environment; the aseptic state of the dried crocodile meat can be ensured; the instant eating effectafter the bag opening can be achieved.

The invention discloses oleanane type triterpenoid saponin as well as extraction and separation method and application thereof. A spectrum technology shows that the oleanane type triterpenoid saponinis a novel compound which is separated from nigella glandulifera. The invention discloses a method for extracting and separating oleanane type triterpenoid saponin from the nigella glandulifera, totalsaponins are obtained after primary extraction and separation with 70% ethanol, the total saponins are fed through a silica gel spectrum column to prepare a crude product of oleanane type triterpenoid saponin, and through separation and purification operation of Sephadex LH-20 gel column and high performance liquid chromatography, a target compound NGTS can be successfully separated. The invention further discloses that the oleanane type triterpenoid saponin has an anti-tumor function, in-vitro anti-tumor experiment shows that the compound has a remarkable inhibition function on stomach cancer cells and glioma cells, and results show that the compound can be further studied and developed as a novel anti-tumor medicine.