Cobalt selenide nano material and application thereof

A cobalt selenide nanometer and nanomaterial technology is applied in the fields of nanomaterial preparation and biomedicine to achieve the effects of enhancing immune function, high sensitivity, and preventing and treating iodine deficiency.

Active Publication Date: 2015-05-06
FUZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, it is still necessary to develop new nanodiagnostic materials for the diagnosis of different cancers. However, in the literature and patents on cobalt selenide nanom

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  • Cobalt selenide nano material and application thereof
  • Cobalt selenide nano material and application thereof
  • Cobalt selenide nano material and application thereof

Examples

Experimental program
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[0027] Example 1

[0028] Cobalt selenide nanomaterials (Co 9 Se 8 ) preparation

[0029] 1) Add 4 mmol of SeO 2 Added to containing 5 mmol Co(Ac) 2 4H 2 O in 20 mL benzyl alcohol, stirred vigorously at room temperature for 1 h;

[0030] 2) The obtained mixture was poured into a 25 mL reactor, and heated at 180 °C for 15 h;

[0031] 3) The precipitate obtained from the reaction was centrifuged, and then washed several times with biological water to obtain the black Co 9 Se 8 ;

[0032] 4) The obtained Co 9 Se 8 Add it into 5 mL of aqueous solution containing 1 mmol polyacrylic acid (PAA), and obtain PAA-modified water-soluble Co 9 Se 8 nanoflakes.

[0033] Income Co 9 Se 8 Atomic force microscopy (AFM) characterization results of nanomaterials can be found in figure 1 , the results of thickness measurement see figure 2 . It can be seen from the figure that the synthesized Co 9 Se 8 The nanomaterials are uniform in size, with an average diameter of about 1...

Example Embodiment

[0034] Example 2

[0035] Cobalt selenide nanomaterials (CoSe 2 ) preparation

[0036] 1) Add 5 mmol of SeO 2 Added to containing 2 mmol Co(Ac) 2 4H 2 O in 20 mL of ethylene glycol, stirred vigorously at room temperature for 1 h;

[0037] 2) The obtained mixture was poured into a 25 mL reactor, and heated at 180 °C for 20 h;

[0038] 3) The precipitate obtained from the reaction was centrifuged, and then washed several times with biological water to obtain black CoSe 2 ;

[0039] 4) The resulting CoSe 2 Add it to 5 mL of aqueous solution containing 0.8 mmol polyethyleneimine (PEI), and after ultrasonication and stirring overnight, PEI-modified water-soluble CoSe 2 nanomaterials.

Example Embodiment

[0040] Example 3

[0041] Preparation of Cobalt Selenide Nanomaterials (CoSe)

[0042] 1) Add 1 mmol of SeO 2 Added to containing 1 mmol Co(Ac) 2 4H 2 In 10 mL ethylene glycol-glycerol 1:1 (v / v) mixture of O, stir vigorously at room temperature for 1 h;

[0043] 2) The obtained mixture was poured into a 25 mL reactor, and heated at 180 °C for 10 h;

[0044]3) The precipitate obtained from the reaction was centrifuged, and then washed several times with biological water to obtain black CoSe;

[0045] 4) The obtained CoSe was added to 5 mL of an aqueous solution containing 0.02 mmol of polyvinyl alcohol (PVA), and the PVA-modified water-soluble CoSe nanomaterials were obtained after ultrasonication and stirring overnight.

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Abstract

The invention discloses a cobalt selenide nano material and an application thereof. A preparation method for the cobalt selenide nano material comprises the following steps: adding a selenium-containing compound and a cobalt salt into a solvent, and fiercely stirring at a room temperature until uniformly mixing; then, pouring a mixed solution into a reaction kettle, and heating for reacting at 180 DEG C for 10-20 hours to obtain precipitates; centrifuging and washing the obtained precipitates, and adding the centrifuged and washed precipitates into an aqueous solution containing a stabilizer; and performing ultrasonic treatment and stirring to obtain a stabilizer-modified water-soluble cobalt selenide nano material. The preparation method for the cobalt selenide nano material disclosed by the invention is simple and convenient to operate, low in energy consumption and easy for large-scale production. The prepared nano particle is uniform in particle granularity and good in dispersion, can be used as a contrast agent for photoacoustic imaging and magnetic resonance imaging, and has important application prospect in the tumor imaging field.

Description

technical field [0001] The invention belongs to the fields of nanomaterial preparation and biomedicine, and in particular relates to a cobalt selenide nanomaterial and its application. Background technique [0002] Cancer, also known as malignant tumor, is a disease caused by abnormal cell proliferation mechanism. In 2012, approximately 14 million new cancer cases were diagnosed worldwide. The report estimates that in 20 years, new cancer cases will grow to 22 million per year. At the same time, the number of cancer deaths will increase from approximately 8.2 million per year to 13 million per year. The World Health Organization (WHO) and its affiliated Cancer Research Institute (IARC) released a research report stating that half of the world's new cancer cases occurred in Asia, most of which occurred in China; and, according to predictions, by In 2030, the number of cancer deaths in China will rise to 12 million. The dramatic increase in cancer deaths is a reminder of t...

Claims

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Application Information

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IPC IPC(8): C01B19/04B82Y30/00
CPCC01B19/04C01P2004/04C01P2004/64
Inventor 李娟宋晓荣杨黄浩余舒娴李诗华
Owner FUZHOU UNIVERSITY
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