Yew genus plant extract and its extraction method and application

A kind of plant extract, technology of extraction method, applied in taxus genus plant extract and the extraction of this extract and its application field

Active Publication Date: 2005-03-16
HARBIN HONGDOUSHAN TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The object of the present invention is to provide a kind of yew plant extract and its extraction method and its application, which not only solves the problem of the sustainable utilization of yew plants, but also

Method used

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  • Yew genus plant extract and its extraction method and application
  • Yew genus plant extract and its extraction method and application
  • Yew genus plant extract and its extraction method and application

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Experimental program
Comparison scheme
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specific Embodiment approach 1

[0004] Embodiment 1: The Taxus genus plant extract in this embodiment is extracted from the branches and leaves of Taxus chinensis as raw materials, and it includes the following components: taxane diterpene compounds, total lignans, and total flavonoids. The taxane diterpene compound accounts for 18-68% of the total volume of the three components, the total lignans accounts for 14-61% of the total volume of the three components, and the total flavonoids accounts for 10-50% of the total volume of the three components. The taxane diterpene compounds include taxane, taxane B, 10-deacetyl baccatin III, citrusin, 10-deacetyl taxane B and taxus pluvialis A; The total lignans include hexetin; the total flavonoids include kaempferol.

specific Embodiment approach 2

[0005] Specific embodiment two: the yew plant extract of the present embodiment is prepared according to the following steps: a, the branches and leaves of the yew genus medicinal material are extracted with an ethanol solvent with a volume concentration of 40 to 95% for 1 to 3 hours, Concentrate into the original extract; b, then add distilled water 30-80 times the weight of the original extract, dissolve the original extract at 60-80°C or under ultrasonic conditions, filter, centrifuge and precipitate after standing; c, use a volume concentration of 50-90% ethanol extracts the above-mentioned precipitate at 60-80°C or ultrasonic conditions, extracts three times, the amount of ethanol added each time is 5-15 times of the weight of the precipitate, filters and centrifuges after standing; d, merge Ethanol extract, add ethanol in the extract, be mixed with the solution that alcohol content is 20~40%, volume is 30~70 times of above-mentioned former extract; e, above-mentioned solu...

specific Embodiment approach 3

[0014] Specific Embodiment Three: The yew plant extract of this embodiment is used as an active ingredient of an anticancer drug for treating lung cancer, melanoma, and breast cancer.

[0015] Summary of pharmacodynamic experiments:

[0016] 1. Criteria for case selection:

[0017] 1. 40 cases of lung cancer, including 22 males and 18 females, the youngest is 29 years old, the oldest is 55 years old, the average age is 43 years old, the shortest course of disease is 2 years, and the longest is 10 years.

[0018] 2. 32 cases of breast cancer, all female, the youngest is 33 years old, the oldest is 54 years old, the average age is 44 years old, the shortest course of disease is 1 year, and the longest is 11 years.

[0019] 3. 25 cases of melanoma, including 20 males and 5 females, the youngest is 44 years old, the oldest is 62 years old, the average age is 50 years old, the shortest course of disease is 5 years, and the longest is 20 years.

[0020] 2. The diagnostic criteria ...

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Abstract

The invention relates to the Yew genus plant extract and its extraction method and application, wherein the extract is extracted from the stems and leaves of Northeastern yew and comprises taxone diterpenoid, total lignans, total flavone. The extract can be used as the effective composition for anti-cancer drugs.

Description

Technical field: [0001] The present invention relates to a plant extract and its extraction process and its application as an anticancer drug, in particular to an active ingredient of an anticancer drug extracted from branches and leaves trimmed from yew plants, its extraction process and its application as an anticancer drug. drug application. Background technique: [0002] The number of patients dying of cancer is increasing every year in our country, and cancer has become one of the diseases that seriously endanger human health in today's society. Paclitaxel extracted from the yew plant is used to treat cancer, and it has been proved to be effective in clinical practice. However, the extraction of paclitaxel mainly comes from the bark of the yew plant, and the content is extremely low, resulting in the death and extinction of the yew plant. CN 1112433A discloses a "taxus plant extract and its application". The extract contains paclitaxel, and paclitaxel has relatively l...

Claims

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Application Information

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IPC IPC(8): A61K31/365A61P35/00C07B63/00C07C49/617C07D305/14C07D307/92C07D311/30
Inventor 王志国
Owner HARBIN HONGDOUSHAN TECH DEV
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