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Fructus akebiae extract, preparation and application thereof

A technology of predicting seeds and extracts, applied in the field of Chinese herbal medicine extracts, can solve the problems of undiscovered helexin and its derivatives, and achieve the effect of scientific and reasonable extraction steps, controllable quality, and less impurity content

Active Publication Date: 2009-12-02
兰晟生物医药(苏州)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Have not yet found that hedera saponin and its derivatives are used for the preparation of reports of drugs for the treatment of depression

Method used

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  • Fructus akebiae extract, preparation and application thereof
  • Fructus akebiae extract, preparation and application thereof
  • Fructus akebiae extract, preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The Fructus Prognostica extract provided in this example is prepared by the following steps: using the medicinal material of Fructus Prognostica as a raw material, it is first subjected to degreasing treatment, followed by ethanol extraction, ethyl acetate treatment and water-saturated n-butanol extraction to obtain the total saponins of Fructus Predictiae The obtained total saponins are degraded and purified by acid-containing ethanol to obtain the extract of Semen Predictia, and the weight percentage of hedera saponin in the extract of Semen Predictus is not less than 60%.

[0034] The preparation method of the above-mentioned predictor extract provided in the present embodiment is as follows:

[0035] (1) Degrease and take 500 g of the coarse powder of the medicinal material of Predictia chinensis, and degrease with 1000 ml of petroleum ether for 20 to 30 minutes;

[0036] (2) Ethanol extracts the coarse powder of the medicinal material to volatilize and remove petro...

Embodiment 2

[0047] The Fructus Prognostica extract provided in this example is prepared by the following steps: using the medicinal material of Fructus Prognostica as a raw material, it is first subjected to degreasing treatment, followed by ethanol extraction, ethyl acetate treatment and water-saturated n-butanol extraction to obtain the total saponins of Fructus Predictiae The obtained total saponins are degraded and purified by acid-containing ethanol to obtain the extract of Semen Predictia, and the weight percentage of hedera saponin in the extract of Semen Predictus is not less than 60%.

[0048] The preparation method of the above-mentioned predictor extract provided in the present embodiment is as follows:

[0049] (1) Degrease and take 500g of the coarse powder of the medicinal material of Predictia chinensis, and degrease with 1500ml of petroleum ether for 20-30min;

[0050] (2) Ethanol extracts the coarse powder of the medicinal material to volatilize and remove the petroleum e...

Embodiment 3

[0061] Refer to Example 1 or Example 2 for the predictor and its preparation method provided in this example.

[0062] The tablet of the extract of Semen Prognostica provided in this example: the extract of Semen Prognostica as active substance, lactose as filler, low-substituted hydroxypropyl cellulose as disintegrating agent, magnesium stearate as lubricant, The binder is an ethanol aqueous solution of povidone, wherein the volume concentration of ethanol is 55%, and the volume concentration of povidone is 3.0%.

[0063] The weights of each component are as follows: 200 mg of Semen Predictus extract, 94 mg of lactose, 4 mg of low-substituted hydroxypropyl cellulose, 2 mg of magnesium stearate, and a total of 300 mg.

[0064] The preparation method of the tablet of the above-mentioned Semen Prognostica extract is as follows: Weigh the Semen Semen Prognostica extract, filler and disintegrating agent according to 50 times the prescription amount, pass through a 60-100 mesh siev...

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Abstract

The invention discloses an fructus akebiae extract, which is prepared by a method of: taking an fructus akebiae medicinal material as a raw material, performing degreasing treatment first, then orderly performing ethanol extraction, ethyl acetate treatment and water saturated normal butanol extraction to obtain total saponin of fructus akebiae, and performing acid-containing ethanol degradation and purification treatment on the obtained total saponin to obtain the fructus akebiae extract, wherein the weight percentage of hederagenin in the fructus akebiae extract is not lower than 60 percent. The invention also discloses the method for preparing the fructus akebiae extract, a preparation and application thereof. The fructus akebiae extract has the advantages of less impurities, high content of active components, and scientific and reasonable steps; the preparation thereof is safe and effective and has reliable quality; and the fructus akebiae extract and the preparation thereof have good antidepression effect.

Description

technical field [0001] The invention relates to an extract of Chinese herbal medicine, in particular to an extract of Semen Predictia, and also relates to the preparation and application of the extract. Background technique [0002] Akebia quinata (Thunb.) Decne., Akebia trifoliata (Thunb.) Koidz. or Akebia trifoliata (Thunb.) Koidz. Var. australis (Diels) Rehd. Dry nearly ripe fruit. Distributed in Jiangsu, Hunan, Hubei, Sichuan, Zhejiang, Anhui and other provinces in my country. Efficacy is soothing the liver and regulating qi, promoting blood circulation and relieving pain, diuresis, and killing parasites. For distending pain in the abdomen and hypochondriac, amenorrhea dysmenorrhea, dysuria, snake bites. It mainly contains akebin (Akebin) A, B, C, D, E, F and G, and its saponins are all hedera saponins. According to "Compendium of Materia Medica · Grass Department (Part 2)", the Prescription of Prediction is used to treat "lack of heart energy, trance, wrong speech, ...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P25/24A61K131/00
Inventor 徐江平
Owner 兰晟生物医药(苏州)有限公司
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