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Inhalation rhododendron mariae solution preparation and preparation method thereof

A rhododendron violet and solution technology, which is applied in the field of pharmacy, can solve problems such as the frequency of use and the influence of dry powder delivery technology, the preparation method of unrecorded formula rules, and the increase in production cost of the device, so as to avoid the first-pass effect and avoid gastrointestinal The effect of road degradation and low production cost

Inactive Publication Date: 2019-12-03
BEIJING INCREASE INNOVATIVE DRUG RESEARCH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Compared with dry powder inhalation and inhalation solution: dry powder inhalation requires a special and complex device, and the complex structure leads to an increase in the production cost of the device, which is not conducive to popularizing the patient's compliance with the inhalation device, frequency of use, and dry powder delivery technology. effective control of
Compared with inhalation solutions, aerosols: ①Aerosols require pressure-resistant containers and valve systems, which are more costly; ②Require mechanical equipment for cooling and filling, and the preparation operations are more troublesome; ③Aerosols have a certain internal Pressure, easy to explode when heated or impacted; ④Aerosol works by the vapor pressure of the propellant, and can be invalidated by the leakage of the propellant
[0005] Due to the vacancy of the prescription inhalation solution dosage form of "Zihua Rhododendron", patients had to use oral preparations, resulting in a large dosage, slow onset of effect, and poor patient compliance.
In addition, there is no record in the prior art about the prescription rules and preparation methods of the prescription inhalation solution dosage form of "Zihua Rhododendron"

Method used

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  • Inhalation rhododendron mariae solution preparation and preparation method thereof
  • Inhalation rhododendron mariae solution preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Rhododendron 300g

[0034] Sodium chloride 0.5g

[0035] Add water for injection to 100mL

[0036] (1) Take Rhododendron violet, add ten times the amount of water to decoct twice, each time for 1 hour, combine the decoction, filter, and concentrate the filtrate under reduced pressure to obtain a concentrate, whose relative density is equivalent to 1ml containing 2-5g Rhododendron violet medicinal material (60°C);

[0037] (2) Add ethanol to the concentrate to make the alcohol content reach 70%, stir well, and refrigerate for 12 hours; filter, concentrate until no alcohol smell, add ethanol to make the alcohol content reach 80%, stir well, and refrigerate for 12 hours; filter , recover ethanol until there is no alcohol smell, add water to half the amount, boil for 15 minutes, put it at room temperature, and refrigerate for 48 hours; filter, and the filtrate passes through a macroporous resin column, which is equivalent to purifying the flavonoids extract of Rhododendron ...

Embodiment 2

[0040] In embodiment 2-4, except adding the adjuvant shown in table 1 before step (3) constant volume, other operation and parameter embodiment 1 are identical;

[0041] The auxiliary materials used in table 1 embodiment 2-4

[0042] serial number Accessories Example 2 0.03g sodium edetate Example 3 0.5ml 0.1M citric acid / sodium citrate Example 4 0.08g ascorbic acid

Embodiment 5

[0044] Rhododendron 350g

[0045] Sodium chloride 0.6g

[0046] Add water for injection to 100mL

[0047] (1) Take Rhododendron azalea, add ten times the amount of water to decoct twice, each time for 1 hour, combine the decoction, filter, and concentrate the filtrate under reduced pressure to obtain a concentrate whose relative density is equivalent to 1ml containing 2-5g medicinal materials (60 ℃);

[0048] (2) Add ethanol to the concentrate to make the alcohol content reach 70%, stir well, and refrigerate for 12 hours; filter, concentrate until no alcohol smell, add ethanol to make the alcohol content reach 85%, stir well, and refrigerate for 12 hours; filter , recover ethanol until there is no alcohol smell, add water to half the amount, boil for 15 minutes, put it at room temperature, and refrigerate for 48 hours; filter, and the filtrate passes through a macroporous resin column, which is equivalent to purifying the flavonoids extract of Rhododendron viola, and the ads...

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Abstract

The invention belongs to the field of pharmaceutical engineering, and particularly relates to an inhalation rhododendron mariae solution preparation and a preparation method thereof. The inhalation rhododendron mariae solution preparation is prepared from a rhododendron mariae effective component and a solvent; and the rhododendron mariae effective component is prepared from rhododendron mariae. The invention further provides the preparation method of the inhalation rhododendron mariae solution preparation. The inhalation rhododendron mariae solution preparation provided by the invention is safe, effective, high in bioavailability, small in application dosage, fast in effect taking and good in effect, has no other toxic and side effect, and is given to a patient through aerosol inhalation,a drug is directly transferred to the respiratory tract, absorption is fast, and action is fast; the administration dosage is reduced, distribution of the drug in other tissue is reduced, and the side effects of the drug are reduced; and additionally, the inhalation rhododendron mariae solution preparation is convenient in administration, good in compliance, and especially suitable for being given to the elderly, children and patient groups with dysphagia.

Description

technical field [0001] The invention belongs to the field of pharmacy, and in particular relates to a rhododendron azalea solution preparation for inhalation and a preparation method thereof. Background technique [0002] Rhododendron azalea is a plant of the Rhododendronaceae family. The active ingredients of Rhododendron azalea are mainly flavonoids, including quercetin and rhododendron A, B, C, and D. The traditional Chinese medicine preparation made of Rhododendron azalea has Antitussive, expectorant, can be used to treat bronchitis, acute and chronic bronchitis. [0003] The prescription formulations of "Purple Rhododendron" sold in the domestic market include tablets and capsules; in addition, for the prescription of "Purple Rhododendron", Zhaoqing Xinghu Pharmaceutical Co., Ltd. has applied for the patent of "Chinese medicine preparation, preparation method and application" (application number 201310178461.3) , the patent application discloses that "Rhododendron azal...

Claims

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Application Information

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IPC IPC(8): A61K36/45A61K9/08A61K47/02A61K47/26A61P11/00A61P11/14A61P11/10
CPCA61K9/0078A61K9/08A61K36/45A61K47/02A61K47/26A61P11/00A61P11/10A61P11/14
Inventor 张保献胡杰王志华
Owner BEIJING INCREASE INNOVATIVE DRUG RESEARCH CO LTD
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