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Pterocephalus hookeri heck n-butyl alcohol extract, as well as preparation method and application thereof

A technology of n-butanol and extract, which is applied in the field of traditional Chinese medicine, can solve the problems of normal cell damage, toxic side effects, and damage to the immune system, and achieve the effect of inducing Hep3B apoptosis, less toxic side effects, and low price

Inactive Publication Date: 2014-08-13
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, chemotherapy is still one of the main means of modern tumor clinical treatment, but chemotherapy lacks the selectivity to normal cells and tumor cells, while killing tumor cells, it also greatly damages normal cells, not only damages the heart, liver, The functions of important organs such as lungs, kidneys, and bone marrow, and damage the immune system, resulting in the loss of the body's self-protection barrier against tumors
The toxic side effects of chemotherapy and tumor drug resistance make the treatment of most cancer patients unsustainable, limiting the treatment intensity and frequency of chemotherapy drugs

Method used

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  • Pterocephalus hookeri heck n-butyl alcohol extract, as well as preparation method and application thereof
  • Pterocephalus hookeri heck n-butyl alcohol extract, as well as preparation method and application thereof
  • Pterocephalus hookeri heck n-butyl alcohol extract, as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] 1.1 Identification of medicinal materials

[0029] Pterocephalus hookeri (C.B.Clarke) Hoeck was collected in Qinghai Province, People's Republic of China in April 2012. It was identified by Professor Zhao Zhili from the School of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine. The specimens are stored in the Prescription Laboratory of School of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine (specimen number: YSC-20120415).

[0030] 1.2 Extraction and preparation of medicinal materials

[0031] Add 2000g of Pterostella herb, add 7L of ethanol with a volume concentration of 95%, heat and extract under reflux at 80°C for 3 times, each time for 2h, combine the extracts, concentrate under reduced pressure to 1 / 5 volume, add an equal volume of water, and volatilize Until there is no alcohol smell, extract with 2 times the volume of petroleum ether and dichloromethane successively for 3 times, then extract with 2 time...

Embodiment 2

[0033] 2.1 identification of medicinal materials: same as Example 1

[0034] 2.2 Extraction and preparation of medicinal materials

[0035] Add 7L of absolute ethanol to 2000g of pterygium, heat and reflux at 80°C for 3 times, 2 hours each time, combine the extracts, concentrate under reduced pressure to 1 / 5 volume, add an equal volume of water, and volatilize until there is no alcohol smell , extracted three times with 2 times the volume of cyclohexane and chloroform in turn, then extracted three times with 2 times the volume of n-butanol, combined the n-butanol, recovered the solvent to obtain the extract of the n-butanol part of Pterocephala.

Embodiment 3

[0037] 3.1 Medicinal material identification: same as Example 1

[0038] 3.2 Extraction and preparation of medicinal materials

[0039] Add 900mL of methanol to 200g of Pteris chinensis, heat and reflux at 80°C for 3 times, 2h each time, combine the extracts, concentrate under reduced pressure to 1 / 5 volume, add an equal volume of water, volatilize until there is no alcohol smell, and then Extract 3 times with 2 volumes of cyclohexane and dichloromethane, then extract 3 times with 2 volumes of n-butanol, combine the n-butanols, recover the solvent to obtain the extract of the n-butanol part of Pterocephala.

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Abstract

The invention relates to a pterocephalus hookeri heck n-butyl alcohol extract, as well as a preparation method and application thereof. Iridoid glycoside is the main component of the extract. The preparation method of the extract comprises the following steps: weighing the pterocephalus hookeri heck medicinal material; performing ethanol extraction under a heating refluxing condition; recycling ethanol from the extract in reduced pressure, and concentrating to obtain a primary extract; suspending the primary extract with water, and extracting with an amphipathic organic solvent to remove liposoluble impurities; extracting with n-butyl alcohol, recycling the solvent to obtain the pterocephalus hookeri heck n-butyl alcohol extract. The invention also discloses application of the extract in preparing anti-tumor medicaments. The extract has the effect of softening hardness to dissipate stagnation, and has remarkable curative effects on common syndromes of malignant tumors, such as blood stasis stagnation, vital energy deficiency, substantial mass and the like.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to an extract of the n-butanol part of Pterocephala, its preparation method and its application in the preparation of antitumor drugs. Background technique [0002] Malignant tumor is a major disease that seriously endangers human life and health, and its mortality rate ranks first in the death toll of human diseases. According to the GLOBOCAN (2008) report, there were 12.7 million new cancer cases and 7.6 million cancer deaths worldwide in 2008. It is estimated that the number of new cancer cases worldwide will increase to 22.2 million in 2030. At present, chemotherapy is still one of the main means of modern tumor clinical treatment, but chemotherapy lacks the selectivity to normal cells and tumor cells, while killing tumor cells, it also greatly damages normal cells, not only damages the heart, liver, The functions of important organs such as the lungs, k...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P35/00
Inventor 朱国福郭晨旭吴迎春潘颖宜朱元章陆怡高玉琼
Owner SHANGHAI UNIV OF T C M
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