Application of Dendrobium candidum extract in the preparation of drugs for preventing and/or treating hyperuricemia

A technology for hyperuricemia and Dendrobium officinale, which is applied in the fields of application, drug combination, plant/algae/fungus/moss components, etc., can solve the problems that have not been found in the application and research of Dendrobium candidum or Dendrobium officinale extract, and achieve non-toxic Side effects, good effect of safety

Active Publication Date: 2018-01-09
NANJING BAOHE BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to our literature research, no application and research of Dendrobium candidum or Dendrobium candidum extracts in the treatment of hyperuricemia or gout have been found

Method used

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  • Application of Dendrobium candidum extract in the preparation of drugs for preventing and/or treating hyperuricemia
  • Application of Dendrobium candidum extract in the preparation of drugs for preventing and/or treating hyperuricemia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1: the preparation of dendrobium candidum crude extract

[0028] Take 2000g of Dendrobium candidum, soak it with 20 liters of 70% ethanol at room temperature for one day, then reflux extraction for 60 minutes, filter the extract, add 16 liters of 70% ethanol to the filter residue, reflux extraction for 40 minutes, and filter. The two extracts were combined and concentrated to dryness in vacuo to obtain 310 g of crude extract of Dendrobium candidum with a yield of 15.5%. Designated as DCE-1.

Embodiment 2

[0029] Embodiment 2: the preparation of dendrobium candidum crude extract

[0030] Take 2000g of Dendrobium candidum, soak it with 20 liters of 50% ethanol at room temperature for one day, then reflux extraction for 60 minutes, filter the extract, add 16 liters of 50% ethanol to the filter residue, reflux extraction for 40 minutes, and filter. The two extracts were combined and concentrated to dryness in vacuo to obtain 500 g of crude extract of Dendrobium candidum with a yield of 25%. Labeled DCE-2.

Embodiment 3

[0031] Embodiment 3: Preparation of Dendrobium candidum total polyphenols

[0032] Take 200 g of the crude extract DCE-1 of Dendrobium officinale prepared in Example 1, dissolve it in water, and perform chromatography with D101 (Xi'an Lanxiao Technology New Materials Co., Ltd.) macroporous adsorption resin. The ratio of the quality of the extract to the quality of the resin is 1:20. Sequentially eluted with water, 30% ethanol, 60% ethanol and 95% ethanol, each gradient eluted with 4-5 column volumes, and the flow rate was 2-3 column volumes / hour. After the elution, the 30% ethanol part, the 60% ethanol part and the 95% ethanol part were concentrated to dryness respectively, and the 30% ethanol part was 60g in total (marked as DC30), and the 60% ethanol part was 93g in total (marked as DC60), A total of 35g of 95% ethanol (marked as DC90).

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Abstract

The invention relates to application of dendrobium officinale extract in preparation of medicine or healthcare product for preventing and / or treating hyperuricemia, hyperuricemia-caused acute gout, chronic gout, gouty arthritis, gout flare, uric acid nephrolithiasis and gouty nephropathy. The dendrobium officinale extract is taken as an active ingredient for preparing the medicine for treating the hyperuricemia, can be used for reducing the concentration of uric acid in the blood, and has a remarkable effect of treating hyperuricemia without toxic or side effects.

Description

technical field [0001] The invention relates to a new application of the extract of Dendrobium officinale. Background technique [0002] In recent years, with the improvement of people's living standards and changes in dietary structure, the intake of sugar, fat, and protein has increased significantly, and the incidence of hyperuricemia and gout has increased day by day, and has become a common disease. [0003] It is generally believed that when the blood uric acid is 465 μmol / L, it is hyperuricemia, and about 5%-12% of patients with hyperuricemia will develop gout. The clinical features are: recurrent gouty acute arthritis, tophi deposition, characteristic chronic arthritis and joint deformities, often involving the kidneys to cause chronic interstitial nephritis and renal uric acid stone formation. The acute attack of gout is an acute inflammatory reaction caused by the deposition of monosodium urate crystal (MSU) in the form of crystals in joints and periarticular tiss...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8984A61P19/06A61P19/02A61P13/04A61P13/12
CPCA23V2002/00A61K36/8984A23V2200/30
Inventor 温尧林张小芸
Owner NANJING BAOHE BIOTECH
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