162results about How to "Raise pain threshold" patented technology

According to one aspect, a stimulation system is provided for electrically stimulating a predetermined site to treat a neurological condition. The system includes an electrical stimulation lead adapted for implantation into a subcutaneous area in communication with a predetermined site, wherein the site is neuronal tissue that is associated with C2 / C3 dermatome area, or stimulating cervical nerve roots and / or stimulating cranial nerves and / or stimulating any area associated with the occipital area. The stimulation lead includes one or more stimulation electrodes adapted to be positioned in the predetermined site. The system also includes a stimulation source that generates the stimulation pulses for transmission to the one or more stimulation electrodes of the stimulation lead to deliver the stimulation pulses to the predetermined site to treat a neurological disorder or condition.

According to one aspect, a stimulation system is provided for electrically stimulating a predetermined site to treat a neurological condition. The system includes an electrical stimulation lead adapted for implantation into a subcutaneous area in communication with a predetermined site, wherein the site is neuronal tissue that is associated with C2 / C3 dermatome area, or stimulating cervical nerve roots and / or stimulating cranial nerves and / or stimulating any area associated with the occipital area. The stimulation lead includes one or more stimulation electrodes adapted to be positioned in the predetermined site. The system also includes a stimulation source that generates the stimulation pulses for transmission to the one or more stimulation electrodes of the stimulation lead to deliver the stimulation pulses to the predetermined site to treat a neurological disorder or condition.

The present invention relates to methods for treating, preventing, managing and / or modifying pain, comprising administering an effective amount of a JNK Inhibitor to a patient in need thereof. Specific embodiments encompass the administration of a JNK Inhibitor, alone or in combination with a second active agent and / or surgery or physical therapy. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.

The invention discloses application of compound traditional Chinese medicine extract in preparation of oral care health products, and relates to the technical field of oral case. Five traditional Chinese medicine extracts, namely a radix rehmanniae extract, a radix angelicae extract, a mulberry teaf extract, a gallnut extract, a white pepper extract and a pepper extract used as auxiliary medicine raw materials having an abirritation function are added into the oral care health products in a process of preparing the oral care products, so that the five traditional Chinese medicine extracts can be safely used in oral care products, such as toothpastes, mouth wash water, tooth powder, throat lozenge, chewing gum and the like, and also can have an obvious abirritation function.

The invention discloses an application of a caulis sinomenii extract to the preparation of oral care products, relating to the technical field of oral care. In the process of preparing oral care products, the caulis sinomenii extract is used as an ancillary drug raw material with an analgesic effect to be added in the oral care products; in the oral care products such as toothpaste, mouth wash, tooth powder, throat lozenge, chewing gum and the like, the caulis sinomenii extract is not only safe in use, but also has an obvious analgesic effect.

The invention discloses a sinomenine vesicle and a preparation method thereof, a preparation containing the sinomenine vesicle and a preparation method of the preparation, which belong to the field of medicament preparations. The sinomenine vesicle is prepared from sinomenine, a nonionic surfactant and an additive. The sinomenine vesicle is preferably prepared into external gel. A sinomenine transdermal administration external preparation has a unique advantage to the medicament. Due to the application of a novel vesicle administration system, transdermal absorption of the medicament is improved, and a clinical curative effect is enhanced. The sinomenine vesicle can be used for treating rheumatism, rheumatoid arthritis, a glomerular disease, hyperosteogeny, spondylitis, arrhythmia, systemic lupus erythematosus, a heroin addict withdrawal symptom and the like.

The invention relates to a gallbladder wood leaf composition containing strictosamide. The gallbladder wood leaf composition is characterized in that the gallbladder wood leaf composition is prepared by combining alkaloid and flavonoid extracted from gallbladder wood leaf; the alkaloid contains strictosamide,10-hydroxy-strictosamide and short snakeroot glucoside; the flavonoid contains kaempferol-3-O-rutinoside and rutin; and the total weight of the three alkaloid and flavonoid is 50-98% of that of the composition, and the ratio of the total weight of the three alkaloid and the total weight of the flavonoid is (10-0.7):(0.5-10). The invention also discloses a preparation of the composition. The composition provided by the invention can play the role of clearing away heat and toxic materials and relieving swelling and pain, and can treat diseases such as acute tonsillitis, acute pharyngitis, acute conjunctivitis, upper respiratory tract infection or chronic pelvic inflammatory disease and appendagitis; and can cure slight and medium pain.

The invention provides a medicine for migraine wind-stasis syndrome and a preparation process thereof. The medicine is characterized by comprising the following raw materials in percentage by weight: 3-9g of szechuan lovage rhizome, 3-9g of angelica dahurica, 5-9g of chastetree fruit, 3-9g of rhizoma gastrodiae, 6-15g of white peony root and 1.5-9g of liquorice. The medicine is a pure traditional Chinese preparation formed by refining and processing according to a famous old traditional Chinese clinical experimental formula and has the functions of expelling wind and activating blood, resuscitating, alleviating pain and treating migraine wind-stasis syndrome and has favorable clinical effects.

In this invention, three genes encoding short chain neurotoxin are obtained by sea snake—Lapemis hardwickii venom gland cDNA library construction and DNA sequencing, named sn12, sn36, and sn160, respectively. The three genes are modified and amplified by PCR method, then cloned into expression vector PETTRX. The three neurotoxin genes are all highly expressed in soluble fusion protein in E. coli stain BL21-DE3 which is used as a expression host when induced with IPTG. Studies on the analgesic effects of the three recombinant short chain neurotoxins showed that three proteins, SN12, SN36 and SN160 all can significantly increase the pain threshold value of mouse.

The invention provides a multifunctional liquid band-aid and a preparation method thereof, and relates to the field of medical treatment and public health. The multifunctional liquid band-aid comprises the following raw materials in parts by weight: 5-15 parts of a film-forming material, 0.1-4 parts of a local anesthetic, 0.5-1.5 parts of an antioxidant, 2-15 parts of a plasticizer, 1-20 parts ofa skin emollient, 0.1-1 part of an aromatic agent and 20-85 parts of a fast-drying solvent. The invention has the following characteristics: the prepared liquid band-aid is adhesive, can form a film at the wound quickly, and has excellent waterproofness; the local anesthetic lidocaine and the antioxidant vitamin E play a synergistic role to relieve wound pain, effectively inhibit bacteria and accelerate wound healing; the liquid band-aid is applicable to various complex-shaped wounds and has a certain toughness and permeability; the formed film is transparent and regular so that the wound healing conditions can be observed at any time; and the liquid band-aid provided by the invention has high safety, no toxicity and no obvious skin irritation.

The invention discloses a high-efficiency magnetic medicament waist belt for treating acute and chronic soft tissue injury, hyperosteogeny and neck shoulder pain or lumbocrural pain of orthopedics and traumatology and a preparation method thereof. The waist belt comprises three parts, namely a waist belt main body, a magnetic sheet and a medicament patch, wherein the medicament patch comprises the following raw material medicaments: orientvine, kadsura pepper stem, Chinese starjasmine stem, suberect spatholobus stem, Japanese honeysuckle stem, common monkshood mother root, kusnezoff monkshood root, nux vomica, dahurian angelica root, drynaria rhizome, safflower, trogopterus dung, ground beeltle, himalayan teasel root, cassia bark and the like. The high-efficiency magnetic medicament waist belt of the invention is worn on the waist of a patient to treat various acute and chronic lumbocrural pain with good treatment effect based on the treatment principle of the magnetic medicament. The magnetic medicament waist belt has the function of treating both symptoms and root causes of the lumbocrural pain caused by various symptoms. The magnetic medicament waist belt has the advantages of simple and convenient method, short treatment period, no surgery, no pain, low medical expense and safe and reliable treatment when used for treating the diseases such as acute and chronic soft tissue injury, hyperosteogeny, neck shoulder pain or lumbocrural pain of orthopedics and traumatology and the like.

The invention discloses a trichomadesis-preventing hair-growing composition comprising the following components: 0.1820-0.6730 part by weight of angelica extract, 0.1820-0.6730 part by weight of divaricate saposhnikovia root, 0.1456-0.5096 part by weight of radix sophorae falvescentis extract, 0.1456-0.5096 part by weight of rhizoma zingiberis extract, 0.1274-0.4459 part by weight of notopterygium root extract, 0.1092-0.3822 part by weight of dodder extract, 0.0728-0.2548 part by weight of ginseng extract and 0.0672-0.2352 part by weight of caulis trachelospermi extract. The composition has better hair-growing, itching relieving and ulcer protecting effects.

The invention relates to a method for preparing efflorescence tang grass extractive, wherein, the content of E-6-O-P-coumaric spatholobus stem is 7-40%. The invention also provides relative preparation and the application in cholecystitis treatment. The invention has stable quality and simple production.

The invention discloses a drug composition for resisting inflammation and easing pain and a preparation method and application thereof. The drug composition is prepared from aconitum sinomontanum nakai and geranium wilfordii maxim as bulk drugs by the unique extraction processes of the invention. The drug composition of the invention has the following advantages: 1, the novel TCM (traditional Chinese medicine) compound for resisting inflammation and easing pain provided by the invention meets the clinical requirements; 2, according to the pharmacological research on the mutual effect and compatible formula of aconitum sinomontanum nakai and geranium wilfordii maxim, the drug composition of the invention can significantly increase the pain threshold of mice compared with single aconitum sinomontanum nakai or geranium wilfordii maxim; 3, the drug composition of the invention has obvious effects of resisting inflammation, easing pain and enhancing human immunity, thus ensuring the wide application prospect; and 4, the drug composition of the invention can be prepared into any preparation by directly feeding the bulk drug of aconitum sinomontanum nakai and geranium wilfordii maxim or by processing the extracts of aconitum sinomontanum nakai and geranium wilfordii maxim, thus meeting the requirements of mass-production.

A medicine Jinganmin with higher curative effect is prepared from aspirin, verigyt hydrochloride, coffin, chlorpheniramine, artificial bezoar and the extracts of honeysuckle flower and isatis leaf. Its preparing process is also disclosed.

The invention belongs to the technical field of medicines, and in particular relates to lactoferrin modified solid lipid nanoparticles, as well as a preparation method and application thereof. The lactoferrin modified solid lipid nanoparticles are characterized in that lactoferrin is modified on the surfaces of solid lipid nanoparticles. The lactoferrin modified solid lipid nanoparticles can wrap medicines therein and can be used as a medicine transfer carrier. The preparation method disclosed by the invention comprises the following steps: synthesising mal-sac-PEG-MS through DCC dehydration reaction, and preparing a nanosuspension by using mal-sac-PEG-MS; then, carrying out lactoferrin sulfhydrylation (Lf-SH) by virtue of a Traut's agent, adding Lf-SH into the nanosuspension, and stirring at a room temperature to carry out protein modification. The lactoferrin modified solid lipid nanoparticles disclosed by the invention have good particle size, Zeta potential and stability. Experimental results show that the lactoferrin modified solid lipid nanoparticles disclosed by the invention are capable of transferring model medicines, such as loperamide and coumarin 6, into brain.

The invention is concerned with a kind of Chinese traditional medicine tablet and its preparation method. Refluence and distill red sage root and red peony root with ethanol, and concentreate the distilled solution into thick paste. Fry snakegourd peel, dandehon herb, tubeimu tuber and Bupleurum root with water, and concentreate the filtrate into thick paste. Mix the said thick paste together, add fine powder of corydalis tuber, dry, grind into fine powder, add starch to mix, pelletize with ethanol, dry, add lubricant, misce bene, pressed disk and film coating. This Chinese traditional medicine tablet has easy product technology, low cost, convenient use, high bioavailability, good taste sense and is convenient for being taken to cure stagnation of the liver-qi, hyperplasia of mammary glands coursed by poison and stasis, mastadenitis, and so on.

The invention discloses application of tetrahydropalmatine and naringin in preparing oral care products, i.e., tetrahydropalmatine and naringin are added into an oral care health-care product as active ingredients with analgesic effect in form of a compound in a process of preparing oral care products. Compared with the prior art, the oral care products provided by the invention not only are safe to use, but also have remarkable analgesic effects.

The invention relates to a traditional Chinese medicine pill for curing amenorrhea resulted from psychotropic drugs and a preparation method thereof. The traditional Chinese medicine pill is prepared from the following bulk drugs in parts by weight: 80-100 parts of salvia miltiorrhiza bunge, 80-100 parts of peach kernel, 80-100 parts of safflower, 30-40 parts of cinnamon, 30-40 parts of fennel, 40-60 parts of folium artemisiae argyi, 40-60 parts of rhizoma cyperi, 40-60 parts of radix linderae, 40-60 parts of angelica sinensis, 40-60 parts of szechuan lovage rhizome, 40-60 parts of twotooth achyranthes root, 40-50 parts of rhizoma corydalis, 40-60 parts of bighead atractylodes rhizome and 40-60 parts of poria. The preparation method is as follows: weighting and processing 900g of the bulk drugs in parts by weight; taking 600g of the processed bulk drugs, adding 1200ml of water in the 600g of the processed bulk drugs, decocting for 40 minutes, removing dregs, decocting once again until the decoction liquid boils, decocting by slow fire and concentrating until the volume of the decoction solution is 400ml for later use; and grinding the rest 300g of the bulk drugs into fine powder, and placing the fine powder in a pelleting container, spraying the concentrated liquid in the pelleting container to prepare into water pills, taking the water pills out of the container and drying to obtain the concentrated pills. The traditional Chinese medicine pill is a pure traditional Chinese medicine preparation, has no toxic or side effect, is convenient to take and has low price.

The invention discloses a process for preparing a capsule for treating milk addiction. After being soaked with water for 15 to 60 minutes, radix salviae miltiorrhizae and cyclodextrins are decocted, and filtering liquid is condensed into thick paste. Self-heal, folium citri reticulatae, radix salviae miltiorrhizae, safflower, radix curcumae, spina gleditsae, nutgrass galingale rhizome and earthworm are decocted with water, and the filtering liquid is condensed into the thick paste. The two thick pastes are combined and are crushed into powder after being dried by reducing pressure, and then the powder is homogeneously mixed with disintegrants to palletize with ethanol, the capsule is made after the palletized pellets are screened, dried, combined into an integral pellet and are filled intothe capsules. The capsule for treating the milk addiction provided by the invention has the advantages of simple technique, low cost, high bioavailability, good mouth feel, and convenient taking, andthe invention is capable of being used for treating symptoms such as breast tenderness, breast bilging pain and the like caused by liver-Qi depression and qi stagnation and blood stasis.

The invention relates to the field of biological medicine, in particular to sunflower flower disc general flavone and an extraction process and application thereof. The extraction process comprises the steps that sunflower flower disc powder is accurately weighed to achieve the constant mass, an ethanol aqueous solution with the volume fraction of 40% to 70% is adopted, the solid-liquid ratio ranges from 1:10 to 1:40, the extraction time ranges from 1 h to 4 h, and extraction is carried out 1-4 times; extracting solutions are mixed, and a crude product of sunflower flower disc general flavoneis obtained; the crude product of sunflower flower disc general flavone is purified with D101 macroporous resin, and the mass ratio of the maxium sampling amount to the D101 macroporous resin is 7:10,an ethanol aqueous solution with the volume fraction of 50% is adopted as an eluent, and the flow velocity is 2.5 mL / min; the eluant is collected, ethanol is recycled, freeze-drying is carried out after vacuum concentration is carried out, and sunflower flower disc general flavone extract is obtained. Sunflower flower disc general flavone extracted through the optimum extraction process has the functions of treating arthrocele, easing pain, treating gouty arthritis and the like.

The invention provides an intelligent neckerchief with a neck treatment function and a control method thereof. The intelligent neckerchief comprises an equipment body and a control device which interacts with the equipment body; the equipment body is provided with a massage device, the massage device comprises an electric signal module, a power source module supplying power to the electric signal module and a USB module for charging the power source module, and the electric signal module conducts data exchange with the control device through a wireless communication module; the control device comprises an intelligent terminal and a data management platform, and the intelligent terminal and the data management platform are connected in an interactive mode. The intelligent neckerchief with the neck treatment function is small, exquisite, original, high in operability and convenient to carry; the intelligent neckerchief is subjected to clinical application for two years in grade-three, class A hospitals, the effective rate reaches 95% or above, and the intelligent neckerchief can effectively solve the problems of cervical vertebra health.

The invention discloses a care medicine composition used before operative anesthesia and a preparation method thereof. The medicine composition is composed of Chinese herbal medicinal ingredients and Western medicinal ingredients. The Chinese herbal medicinal ingredients mainly comprise fruits of Celastrus rosthornianus Loes, sow thistle flower and seeds, rhapis excelsa, the root of Laxleaf Beautifulflower Millettia, all-grass of auriculate dichrocephala, pine among the Indian Bread, fructus terminaliae billericae, aizoon stonecrop herb, valerian, sandalwood extract and crowndaisy chrysanthemum extract. The Western medicinal ingredients mainly comprise aminomethylbenzoic acid, diaminocaproic acid, taurine and cefuroxime. The care medicine composition is scientifically matched according to different medicine effects and characteristics of Chinese and western medicine, is applied to according to indications, has the effects of soothing nerves and calming heart, relieving pain and removing swelling, resisting bacteria and diminishing inflammation, stopping bleeding, enhancing human body immunocompetence and resisting virus infection, and effectively eases preoperative tension, anxiety, fear and other psychic reactions of a patient. The care medicine composition used before operative anesthesia is simple in preparation technology, remarkable in treatment effect and gentle in medicine effect and has the good medical value.

The invention provides a medicinal composition with anti-inflammatory and analgesic effects, which is prepared by taking extracts of lappaconitine hydrobromide and lamiophlomis rotate as raw materials. By performing a pharmacological research on the interaction and the compatibility formula of the extracts of the lappaconitine hydrobromide and the lamiophlomis rotate, results show that the medicinal composition of the invention can remarkably improve the pain threshold value of a mouse compared with the single use of the extract of the lappaconitine hydrobromide or the extract of the lamiophlomis rotate; and a mouse acetic writhing test, a mouse hot tub guy test, a rat paw swelling test caused by carrageenin and a mouse external ear swelling test caused by dimethylbenzene are performed by using the medicinal composition of the invention, so that an optimum formula of the medicinal composition of the invention is obtained. The medicinal composition of the invention has remarkable anti-inflammatory and analgesic effects and wide application prospect.

The invention provides application of cerebrosides in preparation of analgesic drugs. An animal experiment on pharmacology verifies that the cerebrosides are administrated through the ways such as intraperitoneal injection, gavage and skin smearing; all the three ways can improve the threshold values of a mouse to pains caused by heat and mechanical stimulation in a dose-dependent manner; the cerebrosides can remarkably relieve a neuropathic pain, an inflammatory pain and an acetic-acid-induced visceral pain. A cerebroside A or a cerebroside B can inhibit the activity of a vanilloid receptor TRPV1, so that the cerebrosides can increase an algesia threshold value and achieve the purpose of abirritation by lowering the activity of the vanilloid receptor TRPV1. According to the invention, the application of the cerebrosides serving as internal and external analgesic drugs is developed.

The invention discloses a medicinal composition having functions of resisting inflammation and easing pain and a preparation method and application thereof. The medicinal composition is prepared from aconitum sinomontanum and girald daphne bark through a special extraction process of the invention. The medicinal composition has the advantages that: 1, the invention provides a novel Chinese medicament compound prescription used for resisting inflammation and easing pain to meet clinical requirements; 2, pharmacological studies are performed on the interaction and a compatibility prescription of the aconitum sinomontanum and the girald daphne bark, and the results of the studies show that the composition of the invention can significantly improve the pain threshold of a mouse; 3, each mixture ratio of the composition is used for performing a pharmacological experiment to obtain the best formula; 4, the composition has significant functions of anti-inflammatory pain easing and anti-inflammatory immunization and has an extensive application prospect; and 5, the composition not only can be prepared into any preparation by directly using the medicinal materials of the aconitum sinomontanum and the girald daphne bark, but also can be prepared into any preparation by using an aconitum sinomontanum extract and a girald daphne bark extract to meet requirements of large-scale production.

The present invention relates to a dextroketoprofen glucoseoctylamine, its preparation method and medicine composition containing said active component. Its preparation method includes: preparing dextroketoprofen glucoseoctyline salt crude crystal, recrystallization to obtain dextroketoprofen glucoseoctylamine salt and recovering process of (-)-ketoprofen and N-octyl glucosamine. Said compound possesses the actions of clearing away heat, stopping pain and resisting inflammation, its medicine composition can be used for curing rheumatic and rheumatoid arthritis, ankylosing spondylitis, gouty arthritis and various pains.

The invention discloses a composition for treating lumbago and a preparation method of the composition, and aims at providing a traditional Chinese medicine composition which is capable of activating blood, dredging collaterals, relieving swelling and pain and effectively treating lumbago, and is small in side effect. According to the technical main points, the composition is prepared from the following components in parts by weight: 50-100 parts of rose mallow root whole plants, 50-100 parts of mirabilis jalapa whole plants, 30-100 parts of impatiens balsamina whole plants, 100-150 parts of paederia scandens whole plants, 30-100 parts of sansevieria trifasciata leaf whole plants and 10-30 parts of ginger. The composition belongs to the technical field of the traditional Chinese medicine.

The invention discloses a plaster with functions of dredging collaterals, expelling stasis and promoting bone growth. The plaster consists of the following components in parts by weight: 5-15 parts of safflower, 5-15 parts of radix notoginseng, 15-25 parts of eupolyphaga, 15-25 parts of frankincense, 15-25 parts of myrrh, 15-25 parts of rhizoma chuanxiong, 15-25 parts of dragon bone, 15-25 parts of acacia catechu, 15-25 parts of dipsacus asperoides, 40-60 parts of Chinese angelica, 40-60 parts of pangolin scales, 40-60 parts of eucommia ulmoides, 40-60 parts of radix aconiti, 40-60 parts of radix aconiti kusnezoffii 40-60 parts of garden balsam stem, 70-90 parts of rhizoma drynariae, 70-90 parts of rheum officinale and 40-60 parts of elephant hide. According to the plaster disclosed by the invention, rhizoma chuanxiong and radix aconiti kusnezoffii with acrid flavor and hot nature are adopted as main medicines and have the functions of expelling wind and removing cold and warming channels to relieve pain; the main medicines are supplemented by pangolin scales which has the main efficacies of dredging meridian and dispelling pathogenic factors and has the functions of activating blood and resolving stasis and dissipating wind and dredging collaterals, and the functions of activating blood and resolving stasis to relieve pain are enhanced together with the Chinese angelica, frankincense, myrrh, eupolyphaga, radix notoginseng, rhizoma chuanxiong, safflower and dipsacus asperoides; and the garden balsam stem has the functions of dispelling wind and eliminating dampness, relaxing tendon and activating blood and relieving pain.

The invention discloses application of tetrahydropalmatine and a rhizoma imperatae extract in preparing an oral care product, namely adding the tetrahydropalmatine and rhizoma imperatae extract into an oral care product in a compound manner in a technology of preparing an oral care product, wherein the tetrahydropalmatine and rhizoma imperatae extract are used as active components for easing pain. Compared with the prior art, the tetrahydropalmatine and rhizoma imperatae extract are safe to use and have remarkable pain easing effects.