Gallbladder wood leaf composition containing strictosamide as well as preparation and application thereof

A technology of isovinblastam and composition, applied in the field of traditional Chinese medicine composition

Inactive Publication Date: 2012-07-25
江苏中康药物科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the published patent documents for the leaves of the leaves are mainly the technical scheme of the preparation process of the leaves of the leaves, and there is no preparation of total flavonoids and 3 alkaloids (isovinblastam, 10-hydrox

Method used

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  • Gallbladder wood leaf composition containing strictosamide as well as preparation and application thereof
  • Gallbladder wood leaf composition containing strictosamide as well as preparation and application thereof
  • Gallbladder wood leaf composition containing strictosamide as well as preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0181] Example 1. A composition containing isovinblastam vinca lactam, which is composed of alkaloids and flavonoids extracted from leaves of vinca lactam; the alkaloids contain vinblastam, 10-Hydroxy-vinblastam and brevis sergoside; the flavonoids contain kaempferol-3-O-rutinoside and rutin; in the composition, the aforementioned 3 alkaloids and flavonoids The total weight of the compound accounts for 50% by weight of the composition, and the total weight ratio of the aforementioned three alkaloids to the total weight of flavonoids is 10:0.5.

Embodiment 2

[0182] Example 2. A composition containing isovinblastam vinca lactam, which is composed of alkaloids and flavonoids extracted from leaves of vinca lactam; the alkaloids contain vinblastam, 10-Hydroxy-vinblastam and brevis sergoside; the flavonoids contain kaempferol-3-O-rutinoside and rutin; in the composition, the aforementioned 3 alkaloids and flavonoids The total weight of the compound accounts for 98% by weight of the composition, and the total weight ratio of the aforementioned three alkaloids to the total weight of flavonoids is 0.7:10.

Embodiment 3

[0183] Example 3. A composition containing isovinblastam vinca lactam, which is composed of alkaloids and flavonoids extracted from leaves of vinca lactam; the alkaloids contain vinblastam, 10-Hydroxy-vinblastam and brevis sergoside; the flavonoids contain kaempferol-3-O-rutinoside and rutin; in the composition, the aforementioned 3 alkaloids and flavonoids The total weight of the compound accounts for 80% by weight of the composition, and the ratio of the total weight of the aforementioned three alkaloids to the total weight of flavonoids is 10-0.7:0.5-10.

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Abstract

The invention relates to a gallbladder wood leaf composition containing strictosamide. The gallbladder wood leaf composition is characterized in that the gallbladder wood leaf composition is prepared by combining alkaloid and flavonoid extracted from gallbladder wood leaf; the alkaloid contains strictosamide,10-hydroxy-strictosamide and short snakeroot glucoside; the flavonoid contains kaempferol-3-O-rutinoside and rutin; and the total weight of the three alkaloid and flavonoid is 50-98% of that of the composition, and the ratio of the total weight of the three alkaloid and the total weight of the flavonoid is (10-0.7):(0.5-10). The invention also discloses a preparation of the composition. The composition provided by the invention can play the role of clearing away heat and toxic materials and relieving swelling and pain, and can treat diseases such as acute tonsillitis, acute pharyngitis, acute conjunctivitis, upper respiratory tract infection or chronic pelvic inflammatory disease and appendagitis; and can cure slight and medium pain.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a bile leaf composition containing isovinblastam. The present invention also relates to the preparation and application of the above-mentioned composition of the leaves of the eucalyptus. Background technique [0002] Gall wood, also known as ebony, medicinal ebony, and yellow sheep wood, is a plant of the Rubiaceae ebony ebony ( Nauclea officinalis Pierre ex Pitard) dry stems, branches, bark and roots. Born in miscellaneous forests near the top of mountains or in shaded and humid areas on the mountainside, distributed in Guangdong (west and southwest), Guangxi and Hainan and other provinces and regions. Gallwood nature and flavor are bitter, cold, have the effect of heat-clearing and toxic substances removing, reducing swelling and relieving pain. my country's Guangxi, Guangdong and Hainan folks are commonly used in the treatment of colds, fever, pneumonia, enteri...

Claims

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Application Information

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IPC IPC(8): A61K36/74A61P11/00A61P11/04A61P15/00A61P25/04A61P29/02A61K31/7048A61K31/706
Inventor 萧伟丁岗曹亮赵丽李永辉王振中谢达温
Owner 江苏中康药物科技有限公司
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