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Medicinal composition having functions of resisting inflammation and easing pain and preparation method and application thereof

An anti-inflammatory, analgesic and composition technology, applied in the field of pharmaceutical compositions and their preparation, can solve the problems of increasing curative effect and the like

Active Publication Date: 2010-12-15
TIBET QIZHENG TIBETAN MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no combination of the two drugs for anti-inflammatory and analgesic drugs. The combined use of the two increases the curative effect and obtains unprecedented effects

Method used

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  • Medicinal composition having functions of resisting inflammation and easing pain and preparation method and application thereof
  • Medicinal composition having functions of resisting inflammation and easing pain and preparation method and application thereof
  • Medicinal composition having functions of resisting inflammation and easing pain and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0166] Embodiment 1: the preparation of pharmaceutical composition tablet of the present invention

[0167] High Aconitum 95kg Patriarch Hemp 98kg;

[0168] Soak the medicinal material of Aconitum aconitum with 5 times the weight of 75% ethanol for 5 hours, collect the soaking solution, continue to percolate with 75% ethanol, collect the percolation solution, combine the soaking solution and the percolation solution to obtain a mixed solution, and store the soaking solution at a temperature of 60 ° C. , concentrating the mixed solution into a concentrated solution with a relative density of 1.05-1.15, adding sodium hydroxide solution to adjust the pH to 10, standing still, centrifuging, washing the precipitate with water until neutral, and drying to obtain the Aconitum aconitum extract;

[0169] Decocting the zushima medicinal material with 12 times the weight of water for 2 times, each decocting for 3 hours, collecting and combining the extracts, and concentrating the percola...

Embodiment 2

[0171] Embodiment 2: the preparation of pharmaceutical composition capsule of the present invention

[0172] High aconitum 5kg Patriarch hemp 5kg;

[0173] Soak the high aconitum medicinal material with 10 times by weight of 75% ethanol for 18 hours, collect the soaking liquid, and continue to percolate with ethanol until there is no alkaloid reaction, collect the percolating liquid, combine the soaking liquid and the percolating liquid, and reclaim the ethanol to No alcohol smell, dissolve the residue with hydrochloric acid, centrifuge, take the supernatant, pass the supernatant through the cation exchange resin, first elute with water until the effluent is colorless, then analyze with ethanol, collect the ethanol solution, recover ethanol, the above adsorption , The flow rate of washing and analysis is 5 times of bed volume / hour; the recovered liquid is added with ammonia solution, adjusted to pH 10, extracted with chloroform, combined with chloroform solution, recovered to ...

Embodiment 3

[0176] Embodiment 3: the preparation of pharmaceutical composition powder of the present invention

[0177] High aconitum 98kg Patriarch hemp 5kg;

[0178] Take the medicinal materials of Aconitum aconitum and Zushima, mix them and add 6 times the weight of 80% ethanol to reflux and extract once, each time for 4.5 hours, combine the extracts, filter, and concentrate the filtrate at a temperature of 80°C to a relative density of 1.25- The concentrated solution of 1.35 is dried to obtain a dry paste, and conventional auxiliary materials are added to make a clinically or pharmaceutically acceptable powder according to a conventional process.

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Abstract

The invention discloses a medicinal composition having functions of resisting inflammation and easing pain and a preparation method and application thereof. The medicinal composition is prepared from aconitum sinomontanum and girald daphne bark through a special extraction process of the invention. The medicinal composition has the advantages that: 1, the invention provides a novel Chinese medicament compound prescription used for resisting inflammation and easing pain to meet clinical requirements; 2, pharmacological studies are performed on the interaction and a compatibility prescription of the aconitum sinomontanum and the girald daphne bark, and the results of the studies show that the composition of the invention can significantly improve the pain threshold of a mouse; 3, each mixture ratio of the composition is used for performing a pharmacological experiment to obtain the best formula; 4, the composition has significant functions of anti-inflammatory pain easing and anti-inflammatory immunization and has an extensive application prospect; and 5, the composition not only can be prepared into any preparation by directly using the medicinal materials of the aconitum sinomontanum and the girald daphne bark, but also can be prepared into any preparation by using an aconitum sinomontanum extract and a girald daphne bark extract to meet requirements of large-scale production.

Description

field of invention [0001] The present invention relates to a pharmaceutical composition and its preparation method and application, in particular to a pharmaceutical composition with anti-inflammatory and analgesic effects, which uses aconitum aconitum and zumima as raw materials, its preparation method and application. Background technique [0002] Aconitum aconitum is the dry root of Aconitum Sinomontanum Nakai, a plant of the Ranunculaceae family. It is excavated in autumn, and the fibrous roots and aerial parts are removed, and the soil is washed away and dried in the sun. Distributed in Xiaowutai Mountain, Yuxian County, Hebei Province, Shanxi, counties east of Riyue Mountain in Qinghai, Shaanxi, Gansu, Hubei, Sichuan and Guizhou provinces. Its root is poisonous, used as medicine, can reduce swelling and pain, promote blood circulation and dissipate blood stasis, dispel wind, and treat fractures, rheumatic lumbago and leg pain, boils, syphilis, palpitations, stomach pai...

Claims

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Application Information

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IPC IPC(8): A61K36/83A61P29/00A61P37/02
Inventor 张国霞张樱山张朋
Owner TIBET QIZHENG TIBETAN MEDICINE
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