Medicine for treating migraine wind-stasis syndrome and preparation process thereof

A technology of migraine and medicine, which is applied in the field of medicine and its preparation technology for the treatment of migraine with wind-stasis syndrome, can solve the problems of lack of treatment methods and unclear mechanism, and achieve the effect of definite curative effect

Inactive Publication Date: 2010-09-15
辽宁省中医药研究院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the complex and diverse etiology of migraine, the mechanism is still unclear
The treatment of migraine is still in the exploratory stage, and so far there is no ideal treatment method

Method used

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  • Medicine for treating migraine wind-stasis syndrome and preparation process thereof
  • Medicine for treating migraine wind-stasis syndrome and preparation process thereof
  • Medicine for treating migraine wind-stasis syndrome and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The original medicinal materials of the medicine include: Ligusticum chuanxiong 3g, Angelica dahurica 8g, Vitex vulgaris 9g, Gastrodia 5g, Radix Paeoniae Alba 10g, and Licorice 6g.

[0025] Effect on mouse pain model caused by acetic acid: Take 50 mice weighing 18-22 grams. Male and female are divided into model control group, embodiment high, medium and low dose group and Zhengtian pill group randomly according to their body weight. The drug was administered once a day for 3 consecutive days. The model control group was given an equal volume of distilled water. 30 minutes after the last medication, 0.6% glacial acetic acid 0.1ml / 10g was injected intraperitoneally. After 5 minutes of adaptation, the number of writhing reactions in mice within 10 minutes was observed and recorded, and the percentage of drug analgesia was calculated. The results are shown in Table 1.

[0026] Table 1 Effect on mouse pain model induced by acetic acid

[0027]

[0028] * P<0.05 (compared with mo...

Embodiment 2

[0036] The original medicinal materials of the medicine include: Chuanxiong 6g, Angelica dahurica 6g, Vitex 7g, Gastrodia 3g, Radix Paeoniae Rubra 6g, and Licorice 5g.

[0037] Effect on mouse pain model caused by electrical stimulation: select healthy mice weighing 18-22 grams, put them in a mouse holder, scrub the tails with 75% alcohol, and apply a layer of conductive glue to the tails after the alcohol evaporates. The stimulating electrode was placed on the tail of the mouse, and the electrode plate was moistened with 5% saline. Carry out square wave pulse electrical stimulation (voltage 8 volts, frequency 1 Hz, wave width 10 milliseconds) with a physiological experiment multi-purpose instrument, 3 times in a row, with an interval of 5 minutes each time. Select the qualified rats as the qualified rats for the test. A total of 100 qualified mice with neighing reactions were selected three times, half male and half male, and randomly divided into model control groups according...

Embodiment 3

[0043] The original medicinal materials of the medicine include: Ligusticum chuanxiong 9g, Angelica dahurica 6g, Vitex vulgaris 6g, Gastrodia elata 6g, Peony root 9g, and licorice 6g.

[0044] Effect on mice model of reserpine-induced low 5-HT migraine: Take 60 mice of 18-22g and randomly divide them into blank control group, model control group, high, medium and low dose groups and Zhengtian pill according to their weight There were 10 animals in each group, half male and half male. Except for the blank control group, the other groups were injected subcutaneously with reserpine injection 0.25 mg / kg daily for 10 consecutive days, weighed every day, and the dosage was adjusted according to body weight. From the 4th day of modeling, intragastric administration was administered once a day for 7 consecutive days. The blank control group and the model control group were given equal volumes of distilled water. Thirty minutes after the last dose, the pain threshold was measured by the t...

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PUM

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Abstract

The invention provides a medicine for migraine wind-stasis syndrome and a preparation process thereof. The medicine is characterized by comprising the following raw materials in percentage by weight: 3-9g of szechuan lovage rhizome, 3-9g of angelica dahurica, 5-9g of chastetree fruit, 3-9g of rhizoma gastrodiae, 6-15g of white peony root and 1.5-9g of liquorice. The medicine is a pure traditional Chinese preparation formed by refining and processing according to a famous old traditional Chinese clinical experimental formula and has the functions of expelling wind and activating blood, resuscitating, alleviating pain and treating migraine wind-stasis syndrome and has favorable clinical effects.

Description

Technical field [0001] The invention relates to traditional Chinese medicine, and in particular provides a medicine for treating migraine with wind stasis syndrome and a preparation process thereof. Background technique [0002] Current research status of migraine treatment: [0003] Migraine is a common clinical disease with a high incidence of 985.2 / 100,000. It is more common among young people, especially young women, and the prevalence rate is 1:4. Due to the complex and diverse causes of migraine, the mechanism is not clear. The treatment of migraine is still in the exploratory stage, so far there is no ideal treatment method. [0004] Modern medicine believes that the cause of migraine is the change of peripheral microcirculation. There are many factors that cause changes in peripheral microcirculation. Among them, hemorheological factors are very important. As migraine headaches increase blood viscosity and increase red blood cell aggregation during the attack period, they ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8988A61P25/06
Inventor 向绍杰贾冬尤献民邹桂欣
Owner 辽宁省中医药研究院
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