Medicine for treating migraine wind-stasis syndrome and preparation process thereof

A technology of migraine and medicine, applied in the field of medicine and its preparation technology for the treatment of migraine with wind-stasis syndrome, can solve the problems of lack of treatment methods and unclear mechanism, and achieve the effect of definite curative effect

Inactive Publication Date: 2012-05-30
辽宁省中医药研究院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the complex and diverse etiology of migraine, the mechanism is still unclear
The treatment of migraine is still in the exploratory stage, and so far there is no ideal treatment method

Method used

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  • Medicine for treating migraine wind-stasis syndrome and preparation process thereof
  • Medicine for treating migraine wind-stasis syndrome and preparation process thereof
  • Medicine for treating migraine wind-stasis syndrome and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The raw materials of the drug include: Chuanxiong 3g, Angelica dahurica 8g, Vitex 9g, Gastrodia elata 5g, white peony 10g, licorice 6g.

[0025] Effects on the mouse pain model caused by acetic acid: Take 50 mice with a body weight of 18-22 grams. Male and female are divided into model control group, embodiment high, middle and low dose groups and Zhengtian pill group according to body weight, and administered intragastrically Administration was given once a day for 3 consecutive days, and the model control group was given an equal volume of distilled water. 0.6% glacial acetic acid 0.1ml / 10g was injected intraperitoneally 30 minutes after the last dose of the drug, and after 5 minutes of adaptation, the number of writhing reactions in mice within 10 minutes was observed and recorded, and the percentage of drug analgesia was calculated. The results are shown in Table 1.

[0026] Table 1 Effects on acetic acid-induced mouse pain model

[0027]

[0028] ＊ P<0.05 (c...

Embodiment 2

[0036] The raw materials of the drug include: Chuanxiong 6g, Angelica dahurica 6g, Vitex 7g, Gastrodia elata 3g, white peony 6g, licorice 5g.

[0037] Effects on mouse pain models induced by electrical stimulation: select healthy mice with a weight of 18-22 grams, put them in a mouse holder, and scrub the mouse tail with 75% alcohol. After the alcohol evaporates, apply a layer of conductive glue to the tail. The stimulating electrodes were placed on the tails of the mice, and the electrode plates were wetted with 5% saline. Square wave pulse electrical stimulation (voltage 8 volts, frequency 1 Hz, wave width 10 milliseconds) was performed with a multi-purpose instrument for physiological experiments, 3 times in a row with an interval of 5 minutes between each time. Select the rats that responded with hissing all three times as qualified rats for the test. Select 100 qualified rats with screaming responses for 3 times, male and female, and randomly divide them into model contr...

Embodiment 3

[0043] The raw materials of the drug include: Chuanxiong 9g, Angelica dahurica 6g, Vitex 6g, Gastrodia elata 6g, white peony root 9g, licorice 6g.

[0044] Effects on mouse reserpine-lowering 5-HT migraine model: 60 mice of 18 to 22 g were randomly divided into blank control group, model control group, high, medium and low dose groups and Zhengtian pills according to their body weight Group, 10 rats in each group, half male and half male, except the blank control group, the other groups received subcutaneous injection of reserpine injection 0.25 mg / kg daily for 10 consecutive days, weighed every day, and adjusted the dosage according to body weight. From the 4th day of modeling, the rats were administered by intragastric administration, once a day, for 7 consecutive days. The blank control group and the model control group were given equal volumes of distilled water. 30 minutes after the last dose, the pain threshold was measured by the tail flick method, and then blood was co...

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PUM

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Abstract

The invention provides a medicine for migraine wind-stasis syndrome and a preparation process thereof. The medicine is characterized by comprising the following raw materials in percentage by weight: 3-9g of szechuan lovage rhizome, 3-9g of angelica dahurica, 5-9g of chastetree fruit, 3-9g of rhizoma gastrodiae, 6-15g of white peony root and 1.5-9g of liquorice. The medicine is a pure traditionalChinese preparation formed by refining and processing according to a famous old traditional Chinese clinical experimental formula and has the functions of expelling wind and activating blood, resuscitating, alleviating pain and treating migraine wind-stasis syndrome and has favorable clinical effects.

Description

technical field [0001] The invention relates to traditional Chinese medicine, and in particular provides a medicine for treating migraine with wind-stasis syndrome and a preparation process thereof. Background technique [0002] Current status of research on the treatment of migraine: [0003] Migraine is a common clinical disease with a relatively high incidence rate of 985.2 / 100,000. It is more common in young people, especially young women, and the prevalence rate of men and women is 1:4. Due to the complex and diverse etiology of migraine, the mechanism is still unclear. The treatment of migraine is still in the exploratory stage, and so far there is no ideal treatment method. [0004] Modern medicine believes that the cause of migraine is caused by changes in peripheral microcirculation. There are many factors that cause changes in peripheral microcirculation, among which blood rheological factors are very important. Due to the increase of blood viscosity and the enh...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8988A61P25/06
Inventor 向绍杰贾冬尤献民邹桂欣
Owner 辽宁省中医药研究院
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