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Application of red dragon analgesic tablets in treating anti-gout arthritis

A kind of gouty arthritis, gouty technology, applied in the field of medicine

Inactive Publication Date: 2018-11-27
SHANDONG JINHE DRUG RES DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the existing literature and patents, there is no report that Honglong Analgesic Tablets are closely related to blood uric acid and gouty arthritis

Method used

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  • Application of red dragon analgesic tablets in treating anti-gout arthritis
  • Application of red dragon analgesic tablets in treating anti-gout arthritis
  • Application of red dragon analgesic tablets in treating anti-gout arthritis

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0023] Experimental example 1. Effect of Honglong Zhentong Tablets on serum uric acid and anti-inflammatory and analgesic effects of hypoxanthine-induced hyperuricemia mice

[0024] 1 Materials and methods

[0025] 1.1 Instruments FA1004 upper dish balance, 722 spectrophotometer (Shanghai Jingke); LD4-2 low-speed centrifuge (Beijing Medical Centrifuge Factory); water bath box (Beijing Medical Accessories Factory); Shimadzu UV-2550 (Japan ); GJ-8402 hot plate pain measuring instrument (Ninghai Baishi Electronic Medical Instrument Factory).

[0026] 1.2 Drugs and reagents: Red Dragon Analgesic Tablets, Jinhe Tibetan Medicine Co., Ltd., batch number 20170815; Allopurinol Tablets, Chongqing Kerui Pharmaceutical Co., Ltd.; Luo Tongding, Guangzhou Kanghe Pharmaceutical Co., Ltd., batch number 041601; MSU (microcrystalline sodium urate), prepared with sterile saline before use, Sigma, USA; uric acid kit, Nanjing Jiancheng Institute of Biology, batch number 20160820; hypoxanthine, Si...

experiment example 2

[0054] Experimental Example 2. Study on the Effect of Honglongzhentong Tablets on the Joints of Gouty Rats

[0055] 1 Test material

[0056] 1.1 Experimental animals SD rats, male, weighing 190-240 g. Provided by the Experimental Animal Center of Shandong University of Traditional Chinese Medicine, certificate number: SCXK (Lu) 20160015.

[0057] Test Drugs and Reagents

[0058] Test drug: Honglong Analgesic Tablets, specification 0.3 g / tablet, batch number: 20160218, provided by Jinhe Tibetan Medicine Co., Ltd.

[0059] Positive control drug: indomethacin, specification 25 mg / tablet, batch number: A150205, commercially available.

[0060] Reagents: uric acid, purchased from Sigma; Tween 80, Shandong Institute of Chemistry, batch number: 160612; normal saline, Shandong Qidu Pharmaceutical Co., Ltd.; chloral hydrate, Sinopharm Chemical Reagent Co., Ltd., analytically pure, batch number: T20160219; CMC-Na, Shanghai Wanbang Chemical Co., Ltd., batch number: 20160118.

[0061...

Embodiment 1

[0087] Example 1. The application of Honglong Analgesic Tablets in the treatment of gouty hyperuricemia, the dosage is 0.9 g twice a day.

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Abstract

Provided is an application of red dragon analgesic tablets in treating anti-gout arthritis. Through experiments, it is found that the red dragon analgesic tablets can remarkably reduce the serum uricacid level of animals with low or high uricacidemia, obviously improve pathological changes such as joint edema, joint synovial thickening and joint cartilage proliferation of the experiment animals,remarkably inhibit emigration of the leukocyte and PGE2 of rats with gout arthritis, lower the inflammation index and improve the dysfunction score of the animals with gout.

Description

technical field [0001] The invention relates to the application of a Tibetan medicine Honglong Analgesic Tablet in the treatment of anti-gouty arthritis, which belongs to the field of medicine. Background technique [0002] Gout is a disorder of purine metabolism in the human body. Abnormal uric acid metabolism leads to excessive blood uric acid concentration. Uric acid is deposited in the form of sodium salt in joints, cartilage and kidneys, causing a metabolic disease caused by a large amount of tissue inflammatory factors secreted. The current treatment methods for gout mainly include anti-inflammation and analgesia, reducing dietary intake of uric acid, and correcting uric acid metabolism. Traditional Chinese medicine believes that gout belongs to the category of arthralgia, and can be treated by relaxing tendons and activating collaterals, promoting blood circulation and removing blood stasis. [0003] Honglong Analgesic Tablet is a commonly used Tibetan medicine, wh...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/714A61P19/02A61P19/06A61P29/00A61K33/10A61K35/02A61K35/22A61K35/413A61K35/618
CPCA61K35/02A61K33/10A61K35/22A61K35/413A61K35/618A61K36/185A61K36/28A61K36/286A61K36/42A61K36/51A61K36/714A61P19/02A61P19/06A61P29/00A61K2300/00
Inventor 邵成雷单玉刚王栋姬涛
Owner SHANDONG JINHE DRUG RES DEV