The present invention provides a migraine treating wine medicine, which adopts radix anemones rivularis, siegesbeckia orientalis l, herba seu radix clintonae udensis, crocus sativus l, ligusticum chuanxiong hort, angelica dahurica, asarum sieboldii miq, pawpaw, cassia twig, magnolia officinalis, common schizomussaenda rhizome or leaf, corydalis decumbens, cynanchum paniculatum, mulberry root, cocculus laurifolius, japanese pagodatree bark, hazelnut or is added with sansevieria trifasciata prain, slender-spike gouania stem and leaf, reineckia carnea, triangular-toothed shield herb, zhuyelian, flower of javan waterdropwort, helleborus thibetanus franch, datura seed, petasites japonicas, rubus chingii and tithymalus-like pedilanthus herb as the main raw materials. According to the present invention, the clinical treatment effect of the migraine treating spray is observed; the method comprises that the migraine treating spray is externally coated on 32 cases in the treatment group and the control group comprising 32 cases orally take Toutongling capsules; the results show that in the treatment group 29 cases are cured, the 2 cases have the effect, the 1 case does not have the effect, and the total effective rate is 96.87% while in the control group 20 cases are cured, the 4 cases have the effect, the 8 cases do not have the effect, and the total effective rate is 75%, and with the statistic treatment, the significant difference (p is less than 0.05) exists in the treatment effects of the two groups; and the conclusion is that the migraine treatment effect of the migraine treating spray is significant.