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Application of short-chain quinone compounds in preparation of migraine treatment medicines

A compound and short-chain technology, which is applied in the field of biomedicine, can solve problems such as restrictions and side effects, and achieve the effects of low toxic and side effects, high-efficiency treatment, and solving treatment difficulties

Pending Publication Date: 2020-06-16
刘恺鸣
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current preventive drugs have significant side effects and limited use of the population. It is urgent to find a new, safe and effective drug as a (preventive) treatment that is generally applicable to the majority of migraine patients.

Method used

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  • Application of short-chain quinone compounds in preparation of migraine treatment medicines
  • Application of short-chain quinone compounds in preparation of migraine treatment medicines
  • Application of short-chain quinone compounds in preparation of migraine treatment medicines

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] 1. Research content

[0050] Relying on the headache clinic, carry out clinical research on SCQ treatment of migraine in research hospitals. The design type of the study is: randomized, double-blind, placebo-controlled clinical study. It is planned to randomly enroll 114 patients with migraine, 38 patients each in SCQ group, propranolol group (propranolol is currently the highest recommended drug for migraine preventive treatment) and placebo control group. By headache diary, cranial CT, MIDAS and HIT-6 scale, the monthly frequency of migraine attacks, monthly headache days, average duration, pain degree, triggering factors, analgesic drug responsiveness, and response to migraine attacks were observed within 90 days of medication. The impact on quality of life, and comparative evaluation of the efficacy of SCQ in the preventive treatment of migraine.

[0051] 2. Research objectives

[0052] By observing the monthly frequency of migraine attacks within 90 days of medi...

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PUM

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Abstract

The invention relates to the field of biological medicines, and discloses application of short-chain quinone compounds in preparation of migraine treatment medicines. The short-chain quinone compoundscomprise a short-chain naphthoquinone compound, a short-chain benzoquinone compound, a short-chain phenanthrenequinone compound and a short-chain anthraquinone compound. And the short chain is a sidechain with a carbon chain length of 0-12. The short-chain quinone compound (SCQ) is applied to treatment of migraine for the first time, the treatment effect is remarkable, toxic and side effects arelow, and the improvement of the life quality of a patient is superior to the improvement of the highest recommended level of medicines for treating migraine at present. The compounds are of great significance to treatment of migraine which is a disability disease with the highest global morbidity as well as application and popularization of SCQ serving as a medicine. The invention provides saferand more excellent treatment for vast migraine patients, and brings hope for solving the treatment difficulty of migraine.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a medicine for treating migraine. Background technique [0002] Migraine is the third most common disease in human beings, and it is also the most common clinical primary headache type. The clinical manifestation is episodic moderate to severe, throbbing headache. The headache is mostly hemilateral and usually lasts for 4-72 hours. More accompanied by nausea, vomiting, light, sound stimulation or daily activities can aggravate the headache. Migraine is currently the most disabling disease with the highest incidence in the world: in Europe and the United States, more than 80% of workplace sick leave is directly caused by migraine, the prevalence of migraine in my country is 9.3%, and the global prevalence exceeds 10% %. Migraine poses a huge social and economic burden on humans. [0003] The pathogenesis of migraine is very complex. Trigeminal neurovascular activation and cortical spr...

Claims

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Application Information

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IPC IPC(8): A61K31/122A61P25/06
CPCA61K31/122A61P25/06
Inventor 刘恺鸣
Owner 刘恺鸣
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