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Frovatriptan tablet and preparation method thereof

A technology for furotriptan tablets and furotriptan, which can be applied to pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc., and can solve the problems of affecting the rest of patients and unsatisfactory treatment effects. , to improve the quality of rest, relieve vomiting and nausea, and reduce side effects

Inactive Publication Date: 2020-07-17
CP PHARMA QINGDAO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] For this reason, the embodiment of the present invention provides a kind of furovatriptan tablet and preparation method thereof, by adding propranolol and amitriptyline that have preventive effect on migraine, when taking tablet to treat migraine, treat migraine The recurrence of migraine is prevented and good therapeutic effect is provided. The present invention wraps the medicine core with gelatin to reduce the irritation of the medicine to the oral cavity when taking the tablet. Herbal medicine, which is convenient for patients to take tablets, improves the quality of rest of patients, relieves vomiting and nausea, and reduces the side effects of drugs, so as to solve the problems caused by the unsatisfactory treatment effect in the prior art and affect the rest of patients

Method used

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  • Frovatriptan tablet and preparation method thereof
  • Frovatriptan tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A kind of furotriptan tablet, wherein used major ingredient comprises the raw material of following parts by weight: 150 parts of furotriptan succinate, 50 parts of propranolol, 50 parts of amitriptyline, hypromellose 1000 parts, 800 parts of pregelatinized starch, 100 parts of wetting agent, 40 parts of wild chrysanthemum, 40 parts of night vine, 40 parts of skullcap, 40 parts of lotus seeds, 500 parts of edible gelatin.

[0025] Further, the wetting agent is selected as 95% ethanol solution.

[0026] Further, the said wild chrysanthemum, night vine, scutellaria baicalensis and lotus seeds are all ground into powder.

[0027] A furovatriptan tablet also includes a preparation method of the furovatriptan tablet:

[0028] Step 1: Take furovatriptan succinate, propranolol, amitriptyline, hypromellose, and pregelatinized starch according to the corresponding number of prescriptions. After screening, mix evenly, and then add a wetting agent for Stir evenly to make soft me...

Embodiment 2

[0036] A kind of furotriptan tablet, wherein used major ingredient comprises the raw material of following parts by weight: 200 parts of furotriptan succinate, 65 parts of propranolol, 65 parts of amitriptyline, hypromellose 1500 parts, 1000 parts of pregelatinized starch, 125 parts of wetting agent, 55 parts of wild chrysanthemum, 55 parts of night vine, 55 parts of skullcap, 55 parts of lotus seeds, 650 parts of edible gelatin.

[0037] Further, the wetting agent is selected as 95% ethanol solution.

[0038] Further, the said wild chrysanthemum, night vine, scutellaria baicalensis and lotus seeds are all ground into powder.

[0039] A furovatriptan tablet also includes a preparation method of the furovatriptan tablet:

[0040] Step 1: Take furovatriptan succinate, propranolol, amitriptyline, hypromellose, and pregelatinized starch according to the corresponding number of prescriptions. After screening, mix evenly, and then add a wetting agent for Stir evenly to make soft m...

Embodiment 3

[0048] A kind of furotriptan tablet, wherein used major ingredient comprises the raw material of following parts by weight: 250 parts of furovatriptan succinate, 80 parts of propranolol, 80 parts of amitriptyline, hypromellose 2000 parts, 1200 parts of pregelatinized starch, 150 parts of wetting agent, 70 parts of wild chrysanthemum, 70 parts of night vine, 70 parts of skullcap, 70 parts of lotus seeds, 800 parts of edible gelatin.

[0049] Further, the wetting agent is selected as 95% ethanol solution.

[0050] Further, the said wild chrysanthemum, night vine, scutellaria baicalensis and lotus seeds are all ground into powder.

[0051] A furovatriptan tablet also includes a preparation method of the furovatriptan tablet:

[0052] Step 1: Take furovatriptan succinate, propranolol, amitriptyline, hypromellose, and pregelatinized starch according to the corresponding number of prescriptions. After screening, mix evenly, and then add a wetting agent for Stir evenly to make soft...

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Abstract

The embodiment of the invention discloses a frovatriptan tablet and a preparation method thereof, and in particular to the technical field of frovatriptan medicines. The frovatriptan tablet comprisesthe following raw materials in parts by weight: frovatriptan succinate, propranolol, amitriptyline, hydroxypropyl methylcellulose, pregelatinized starch, a wetting agent, wild chrysanthemum flowers, tuber fleeceflower stems, baical skullcap roots, lotus seeds and edible gelatin. According to the invention, the propranolol and the amitriptyline which have a prevention effect on migraine are added,so that when the tablet is taken for migraine treatment, recurrence of migraine is prevented, and a good treatment effect is provided. According to the invention, the medicine core is wrapped by the gelatin, so that stimulation of the medicines to the oral cavity is reduced when the tablet is taken. The wild chrysanthemum flowers, the tuber fleeceflower stems, the baical skullcap roots and the lotus seed are mixed with the gelatin, and the medicinal herbs for calming the heart are used, so that a user can conveniently take the tablet, rest quality of the patient is improved, the vomit and nausea feeling is relieved, and side effects of the medicine is reduced.

Description

technical field [0001] The embodiment of the present invention relates to the technical field of frovatriptan medicines, in particular to a furovatriptan tablet and a preparation method thereof. Background technique [0002] Migraine is the most common type of primary headache clinically. The main clinical manifestation is paroxysmal moderate to severe, throbbing headache. The headache is mostly hemilateral and usually lasts for 4 to 72 hours. Headaches can be aggravated by stimuli or everyday activities and relieved by quiet surroundings and rest. Migraine is a common chronic neurovascular disease. It usually occurs in children and adolescence, and reaches the peak in young and middle-aged adults. It is more common in women, and the ratio of male to female patients is about 1:2~3. % to 10%, often with a genetic background, migraine can be quickly relieved by oral painkillers, and when it can occur, you can take some oral ibuprofen sustained-release capsules, these painkill...

Claims

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Application Information

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IPC IPC(8): A61K36/704A61K9/20A61K47/42A61K47/38A61K47/36A61P25/06A61P25/20A61K31/135A61K31/138A61K31/403
CPCA61K9/2054A61K9/2059A61K9/2063A61K31/135A61K31/138A61K31/403A61K36/287A61K36/539A61K36/62A61K36/704A61P25/06A61P25/20A61K2300/00
Inventor 陈阳生孙桂玉刘晓霞刘薇张怀征牛建兴王清亭王婷婷
Owner CP PHARMA QINGDAO CO LTD
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