Herba hedyotis diffusae extract, pharmaceutical preparation, preparing process and application thereof

The technology of Hedyotis diffusa and medicinal preparations is applied in the directions of medicinal combinations, medicinal formulations, plant raw materials, etc., which can solve the problems of slow medicinal effect, no application of cholecystitis, and insignificant choleretic effect, and achieves stable quality, good medicinal effect

Inactive Publication Date: 2007-08-08
CHANGSHA SANYOU PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

3. The in vitro antibacterial effect is not significant, and the high-concentration decoction has inhibitory effect on Pseudomonas aeruginosa, Salmonella typhi, Staphylococcus aureus, Proteus, Shigella, Influenza bacillus, Pneumococcus, hemolytic streptococcus, Neisseria
[0004] At present, Hedyotis diffusa is mostly used as a compound preparation and used in combination with other medicines. There is no report on the study of Hedyotis diffusa extract as a drug alone, let alone the application of Hedyotis diffusa in the treatment of cholecystitis
However, the current medicines for treating cholecystitis are mainly compound Chinese medicines such as Xiaoyan Lidan Tablets, whose efficacy is relatively slow, and the choleretic effect is not obvious

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0123] Take 10kg of Hedyotis diffusa medicinal material, cut it into 2-3cm pieces, use 11 and 8 times the amount of 60% ethanol to reflux extract twice, each time for 1 hour, combine the alcohol extracts, filter, recover the ethanol under reduced pressure and concentrate to about 30L (60°C, -0.07~-0.09MPa), stir and add 10g.L of 15% (v / v) -1 Chitosan solution (prepared by 1% acetic acid) was left to stand for 12 hours, filtered, and the supernatant was concentrated under reduced pressure to about 10L, and loaded into a treated 10L polyamide column (30-60 mesh) at a flow rate of about 1 column volume / hour, washed 20L with water, discarded, eluted with 30L of 70% ethanol, concentrated the eluent under reduced pressure (60°C, -0.07~-0.09MPa) to a thick paste, dried in vacuum (60°C, -0.09MPa), Obtain the dry paste of the extract. Crush the extract into fine powder, add 100g starch, 10g sodium carboxymethyl starch, mix well, make soft material with 75% ethanol, granulate with 24 m...

Embodiment 2

[0145] Take 10kg of Hedyotis diffusa medicinal material, pulverize, and extract twice with 10 times the amount of 40% ethanol under reflux, each time for 1 hour, combine the ethanol extracts, filter, recover ethanol under reduced pressure and concentrate to about 30L (60°C, -0.07~-0.09MPa), stirring and adding 10g.L of 15% (v / v) -1Chitosan solution (prepared by 1% acetic acid), let it stand for 12 hours, filter, and the supernatant was concentrated under reduced pressure to about 10L, and the sample was loaded to the treated 10L polyamide column (30-60 mesh), and the flow rate was About 1 column volume / hour, washed 20L with water, discarded, eluted with 30L of 0.4% ammonia water, concentrated the eluent under reduced pressure (60°C, -0.07~-0.09MPa) to a thick paste, and spray dried to obtain the extract. Add 100g microcrystalline cellulose and 10g sodium carboxymethyl starch to the fine powder of the extract, mix well, make soft material with 75% ethanol, granulate with 24 mes...

Embodiment 3

[0148] Take 10kg of Hedyotis diffusa medicinal material, pulverize it, and extract twice with 10 times the amount of water-saturated acetone under reflux, each time for 2 hours, combine the alcohol extracts, filter, recover acetone, add water to adjust the volume to about 30L (60°C, - 0.07~-0.09MPa), stir and add 10g.L of 15% (v / v) -1 Chitosan solution (prepared by 1% acetic acid), let it stand for 12 hours, filter, and the supernatant was concentrated under reduced pressure to about 10L, and the sample was loaded to the treated 10L polyamide column (30-60 mesh), and the flow rate was About 1 column volume / hour, washed 20L with water, discarded, eluted with 30L of 0.4% ammonia water, concentrated the eluent under reduced pressure (60°C, -0.07~-0.09MPa) to a thick paste, and spray dried to obtain the extract. Add 100g of starch and 10g of sodium carboxymethyl starch to the fine powder of the extract, mix well, make a soft material with 75% ethanol, granulate with a 24-mesh siev...

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PUM

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Abstract

The invention relates to a method for preparing efflorescence tang grass extractive, wherein, the content of E-6-O-P-coumaric spatholobus stem is 7-40%. The invention also provides relative preparation and the application in cholecystitis treatment. The invention has stable quality and simple production.

Description

technical field [0001] The invention relates to a traditional Chinese medicine Hedyotis diffusa extract and a pharmaceutical preparation prepared therefrom, and also relates to a preparation method of Hedyotis diffusa extract and its use for treating cholecystitis. Background technique [0002] Hedyotis diffusa is the whole herb of Rubiaceae Hedyotis diffusa. It mostly grows in wet fields, ditches, roadsides and grasslands, and is distributed in most parts of the country. Hedyotis diffusa contains triundecane, stigmasterol, sitosterol, ursolic acid, oleanolic acid, ursolic acid, p-coumaric acid, β-sitosterol, β-sitosterol-D-glucoside, etc. . Hedyotis diffusa is cold in nature, sweet and bitter in taste, and returns to the heart, lung, liver, and large intestine meridian. Hedyotis diffusa: 1. For intestinal abscess, lung abscess, sore boils, swelling and pain, poisonous snake bites. Intestinal abscess, lung abscess, light syndrome single use is effective. Sores, furuncles...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/74A61K31/7028A61P1/16A61K31/192
Inventor 周应军曾光尧谭建兵吴孔松谭桂山
Owner CHANGSHA SANYOU PHARMA
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