The invention belongs to the technical field of photoresponse antibacterial dressings, and discloses PCN-coated Au / GOx-F68 / F127 antibacterial temperature-sensitive hydrogel and a preparation method and application thereof.The PCN-coated Au / GOx-F68 / F127 antibacterial temperature-sensitive hydrogel can complete conversion of gel and
sol under the condition of 4-37 DEG C, PCN-coated Au nano-
enzyme is constructed by means of an in-situ growth method, and after the PCN-coated Au nano-
enzyme is integrated with GOx, a self-activated enzymatic
cascade reaction is formed by means of the hydrogel. GOx decomposes glucose to generate H2O2 and
gluconic acid, the pH of a wound is reduced, PCN-coated Au decomposes endogenous H2O2 under an acidic condition to generate ROS for sterilization, limitation of a high-blood-
sugar and high-pH environment on catalytic activity is avoided, meanwhile, photodynamic synergistic
antibiosis is achieved, the synthesis condition is mild, the process is simple, and economical and feasible effects are achieved. The hydrogel has thermosensitivity, can relieve
wound pain, does not loosen after absorbing
exudate, has no residue, and does not adhere to a
wound surface when being removed. Under the
irradiation of visible light, the methicillin-resistant
staphylococcus aureus and the
escherichia coli capable of producing extended-spectrum beta-lactamase can reach gt within 0-30 minutes; the
clearance rate is 99.9%, and a new way is provided for developing novel medical dressings for treating diabetic bacterial infection wounds.