The invention belongs to the technical field of photoacoustic response antibacterial dressings, and discloses PDA (at) Ag (at) Ag2S / SA / F68 / F127 antibacterial temperature-sensitive hydrogel as well as a preparation method and application thereof.The PDA (at) Ag (at) Ag2S / SA / F68 / F127 antibacterial temperature-sensitive hydrogel can complete conversion of gel and
sol under the condition of 4-60 DEG C, PDA (at) Ag (at) Ag2S nano-
enzyme is constructed by means of an in-situ growth method, a PDA (at) Ag (at) Ag2S nano-
composite material can generate
electron-hole pairs under photoacoustic combination, then
reactive oxygen species (ROS) is generated, and the antibacterial temperature-sensitive hydrogel can be used for preparing antibacterial temperature-sensitive hydrogel. The photoacoustic response
antibacterial effect is realized. Meanwhile, PDA (at) Ag (at) Ag2S has
peroxidase (POD)-like activity, and the material can catalyze endogenous
hydrogen peroxide (H2O2) in a common wound microenvironment with the pH value of 7-8 to generate
reactive oxygen species (ROS) with high
toxicity, such as hydroxyl free radicals (. OH), so that efficient killing of various
bacteria under photoacoustic combination is realized. Synthesis conditions are mild, and the process is simple, economical and feasible. The hydrogel has thermosensitivity, can
resist inflammation, stop bleeding and relieve
wound pain, does not loosen after absorbing seepage, is free of residues and does not adhere to a
wound surface when being removed, and a new way is provided for developing novel medical dressings for treating
drug-resistant bacterial infection wounds.