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50 results about "Clinical pain" patented technology

Pain assessment system and method based on multi-modal physiological signals

The invention provides a pain assessment system and method based on multi-modal physiological signals. The system comprises a multi-modal signal acquisition module, a signal preprocessing module, a multi-modal feature extraction module, a deep fusion analysis module, an individualized calibration module and a result output and early warning module. By synchronously collecting and analyzing multi-dimensional data such as facial expressions, sound features, physiological signs and behavior responses and combining deep learning and multi-modal information fusion technologies, objective quantitative evaluation and real-time monitoring of the pain degree are achieved, and accurate decision support is provided for clinical pain management.
Owner:NANJING CHILDRENS HOSPITAL

Clinical pain management decision support system and training method based on severe games

According to the clinical pain management decision support system and the training method based on the severe games, the pain management process is standardized by using the functions of warning, decision making, data storage and the like of the clinical pain management decision support system, a standardized pain nursing document is automatically generated, and timeliness and safety of pain management of a patient are guaranteed. In addition, a relaxed game training mode is adopted, so that clinical medical staff can relieve pain for the patient in a real and safe environment, more learning and practicing opportunities can be provided for the clinical medical staff, the effect better than that of a traditional learning mode is obtained, and the patient cannot be hurt; meanwhile, by means of emerging technical means, skills are trained, professional knowledge is learned or professional guidance is sought anytime and anywhere, the availability of medical professional learning resources is improved, clinical medical staff are not limited by time and space, and the time and economic cost for mastering professional skills is reduced.
Owner:THE FIRST HOSPITAL OF LANZHOU UNIV

Liver cancer thermal ablation path planning system based on deep reinforcement learning

The invention relates to the technical field of ablation path planning, in particular to a liver cancer thermal ablation path planning system based on deep reinforcement learning. The system comprises a target and dangerous area mask generation module, a pipeline distance field construction module, a thermal field prediction module, a breathing deformation prediction module, a multi-scale feature fusion module, a behavior preference reward module, a composite reward function module and a decision output module. Clinical pain points such as breathing interference, dangerous area avoidance and individualized adaptation are broken, the precision and safety of the liver cancer thermal ablation operation are improved, normal tissue damage and complications are reduced, intelligent decision support is provided for interventional therapy, and liver cancer minimally invasive therapy is promoted to be upgraded to precision and intelligence.
Owner:THE THIRD MEDICAL CENT OF THE CHINESE PEOPLES LIBERATION ARMY GENERAL HOSPITAL

Myocardial infarction metabolic rhythm intelligent typing and administration decision-making method and myocardial infarction metabolic rhythm intelligent typing and administration decision-making system

The invention relates to the technical field of medical typing decision, in particular to a myocardial infarction metabolic rhythm intelligent typing and administration decision method and system.The myocardial infarction metabolic rhythm intelligent typing and administration decision method comprises the steps that biological clock genes BMAL1 mRNA, a USP2-BCAT2 compound and branched chain amino acid BCAs are synchronously detected through a multi-index joint detection kit; a BCAs circadian rhythm curve is collected through a wearable monitoring patch integrating a sweat BCAs sensor and an electrocardiogram monitoring module; the invention relates to a random forest model myocardial infarction metabolic rhythm typing intelligent model. A multi-dimensional dynamic typing system is established by integrating BMAL1 methylation, a USP2-BCAT2 compound and BCAs rhythm fluctuation, and high-risk subtypes needing metabolic intervention are accurately distinguished; the concentration fluctuation of the BCAs is monitored in real time through the intelligent patch, and the abnormal metabolism state is pre-warned; and the administration opportunity is automatically optimized based on the individualized biological clock phase, and clinical pain points such as insufficient typing precision, abnormal early warning lag and administration time sequence mismatch are solved.
Owner:XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV

Pain assessment system using neonatal facial expression image analysis

The present application relates to the technical field of medical image processing, in particular to a pain assessment system for neonatal facial expression image analysis, comprising a data acquisition module, a facial expression manifold construction module, a curvature field analysis module, a spatiotemporal feature hierarchical analysis module and a pain assessment and alarm module, the facial expression manifold construction module maps discrete facial feature points to a Riemann manifold space to construct an individualized expression manifold model; the curvature field analysis module calculates a facial expression dynamic curvature field and extracts micro-motion curvature features; the spatiotemporal feature hierarchical analysis module performs multi-scale decomposition on the curvature features to identify pain-related micro-motion units; the pain assessment and alarm module calculates a pain score and performs early warning, the present application significantly improves micro-expression capture sensitivity, is robust to changes in shooting conditions, improves the ability to distinguish different types of pain, realizes objective quantitative assessment and multi-level early warning of the pain state of neonates, and provides reliable technical support for clinical pain management.
Owner:THE SEVENTH MEDICAL CENTER OF PLA GENERAL HOSPITAL

Markers for diagnosing unexplained recurrent abortion and application thereof

The invention belongs to the technical field of reproductive medicine and clinical metabolism intervention, and particularly relates to a group of markers for diagnosing unexplained recurrent abortion and application thereof. Aiming at the clinical pain point that unexplained recurrent abortion (URSA) lacks accurate metabolic typing diagnosis indexes and targeted treatment means, based on detection of a large number of clinical samples and verification of cell experiments, direct association between down-regulation of levels of choline related metabolites and trimethylamine oxide (TMAO) of decidua tissues and the RSA is disclosed for the first time; the core effect of TMAO in-situ synthesis of decidua stromal cells (DSC) in regulation and control of the decidualization process is determined; meanwhile, an RSA indication screening system of joint detection of serum creatinine and decidua choline metabolism is constructed, a targeted TMAO targeted intervention scheme is formed in a matched mode, a diagnosis and treatment closed loop of RSA from precise typing to targeted treatment is achieved, and a brand new technical path is provided for clinically solving the URSA diagnosis and treatment problem.
Owner:XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE

A disposable purse string locking device and method

PendingCN122342609AClinical painAntalgic position
This invention discloses a disposable purse sewing locking device and method, including a housing assembly, a one-way locking element, an elastic pressure claw, an elastic element, a graded fine adjustment button, a tapered guide inlet, a pre-installed arched soft pad, an anti-slip positioning wing, and a preset weak area. A one-way locking element and an elastic pressure claw work together to form a wedge-shaped locking structure. The elastic element drives the elastic pressure claw to continuously press against the one-way locking element, achieving one-way irreversible locking of the suture. Tactile feedback and tension-linked indicator color blocks provide dual confirmation. The tapered, narrowing flared opening is compatible with multiple suture sizes. The anti-slip positioning wing is connected to the housing via a narrow-waisted pivot, and springs open elastically under the axial tension generated by suture tightening. The adjustable button has a two-stage locking confirmation structure: a temporary locking state allows for minor adjustments, and pressing again triggers irreversible locking. A pre-set weak area has a pull-out pin for quick release; in emergencies, the doctor can pull the cord with one hand to quickly release the suture. This device can be a single-channel or dual-channel parallel structure. The dual-channel structure allows two purse-string sutures to be inserted simultaneously and independently perform tightening, fine-tuning, and locking operations. This device is disposable, simple to operate, and systematically addresses clinical pain points.
Owner:SHANDONG XINGYAO FUTURE MEDICAL TECHNOLOGY CO LTD

Innovative aspirator head special for pleural exfoliation

The innovative aspirator head comprises a tubular handle and a working head part arranged at the front end of the tubular handle, an aspiration channel is formed in the tubular handle, the working head part is an integrally formed flat wedge-shaped aspiration head, and the aspiration channel is communicated with the aspiration channel. At least one suction hole communicated with the suction channel is formed in the stripping working surface; in the whole stripping process, wound surface errhysis is continuously sucked away through the suction holes, it is ensured that the operation view is clear, and the flat wedge-shaped head cannot pierce lung tissue due to the large contact area and the small pressure intensity; meanwhile, the flat wedge-shaped head is easy to insert into a gap, the pure flat blunt end ensures that the front end cannot be punctured, the clinical pain point that a traditional round-head aspirator is easy to poke into or tear fragile lung tissue is effectively solved, stable poking and separation of a fiberboard are achieved by increasing the stress area, and the safety and controllability of an operation are remarkably improved.
Owner:徐世超

Plasma polypeptide marker COL1A2 related to tumor bone metastasis and pain and application

The invention relates to the field of biological detection, and discloses a plasma polypeptide marker COL1A2 related to tumor bone metastasis and pain and application. Aiming at the problem that early diagnosis of bone cancer pain and tumor bone metastasis is difficult, by detecting the level of circulating COL1A2 in plasma, it is found that the circulating COL1A2 is remarkably up-regulated in patients with tumor bone metastasis and bone cancer pain and is remarkably related to clinical pain score and tumor staging. A sensitive and specific COL1A2 detection method is established by adopting an enzyme-linked immunosorbent assay (ELISA) technology, and occurrence and staging of bone cancer pain and tumor bone metastasis can be identified with high prediction efficiency that AUC is 0.95 and 0.94 respectively. The method is low in detection cost, simple and convenient to operate and suitable for clinical popularization and application, and scientific basis and technical support are provided for screening of high-risk groups, early diagnosis of bone metastasis, pain staging and personalized treatment. The invention has important significance for optimizing diagnosis and treatment strategies of patients suffering from bone cancer pain and improving clinical transformation efficiency.
Owner:SUN YAT SEN UNIVERSITY CANCER CENTER (CANCER HOSPITAL AFFILIATED TO SUN YAT SEN UNIVERSITY CANCER RESEARCH INSTITUTE OF SUN YAT SEN UNIVERSITY)

A plasma polypeptide marker COL1A2 associated with tumor bone metastasis and pain and its application

This invention relates to the field of biological testing and discloses a plasma polypeptide marker, COL1A2, associated with tumor bone metastasis and pain, and its applications. To address the difficulties in early diagnosis of bone cancer pain and tumor bone metastasis, this study examined circulating COL1A2 levels in plasma and found that it was significantly upregulated in patients with bone metastasis and pain, and correlated significantly with clinical pain scores and tumor stage. Using enzyme-linked immunosorbent assay (ELISA) technology, a sensitive and specific COL1A2 detection method was established, capable of identifying the occurrence and stage of bone cancer pain and tumor bone metastasis with high predictive efficacy of 0.95 and 0.94, respectively. This assay is low-cost and simple to operate, making it suitable for clinical application. It provides scientific basis and technical support for screening high-risk populations, early diagnosis of bone metastasis, pain staging, and personalized treatment. This invention is of great significance for optimizing diagnostic and treatment strategies for patients with bone cancer pain and improving clinical translation efficiency.
Owner:SUN YAT SEN UNIVERSITY CANCER CENTER (CANCER HOSPITAL AFFILIATED TO SUN YAT SEN UNIVERSITY CANCER RESEARCH INSTITUTE OF SUN YAT SEN UNIVERSITY)

Tooth pad for preventing tongue from being bitten under electrical stimulation

The invention discloses a bite pad for preventing tongue bite under electrical stimulation, the bite pad comprises a supporting and fixing unit and an intelligent detection system, the supporting and fixing unit and the intelligent detection system are integrally assembled, and the supporting and fixing unit comprises a connecting piece, a self-adaptive deformation body, a fitting part and a ventilation channel; the intelligent monitoring system comprises a pressure monitoring module, a signal processing module, an alarm module and a wireless transmission module, and it is ensured that no displacement or falling-off is generated under electrical stimulation through the elastic buckle, the magnetic attraction fixing band and a fixing structure of the tracheal catheter; the pressure monitoring module is combined with the signal processing module with a built-in dynamic threshold value algorithm and the alarm module linked with local acousto-optic and remote nurse stations to guarantee multi-terminal timely response, and clinical pain points such as tongue bite under electrical stimulation, insufficient fixation of a tooth cushion, lack of oral care and early warning lag are solved.
Owner:晋江市医院(上海市第六人民医院福建医院)

Pain relief system based on brain neural oscillation regulation

The application provides an analgesia system based on brain nerve oscillation regulation, relates to the technical field of pain regulation, and first establishes a brain signal standardization information base of healthy people; for each pain patient, the brain nerve signal index of the pain patient is compared with a standard normal range obtained from the brain signal standardization information base of healthy people to determine abnormal electroencephalogram nerve indexes of each pain patient; then, according to the pain specificity of each pain patient, the correlation between the behavior indexes and the abnormal electroencephalogram nerve indexes of the pain patient is analyzed to determine potential regulation target points; the regulation target points to be intervened and regulation modes are selected from the potential regulation target points; different regulation modes are selected according to actual requirements to regulate the pain of the pain patient; and then, the pain regulation effect is evaluated, so that the effect of relieving pain is achieved, the analgesia system has the characteristics of safety, economy and easy operation, and is expected to be applied to the treatment of clinical pain.
Owner:SHENZHEN UNIV

Use of a wdr5 inhibitor in the manufacture of a medicament for treating ebv-positive lymphoma

PendingCN122342820ADiseaseSide effect
The present application relates to the field of biological medicine, and more particularly to the application of WDR5 inhibitors in the preparation of drugs for treating EBV-positive lymphoma. The WDR5 inhibitor is a small molecule inhibitor, including one or more of WDR5-specific degradation agent MS67, WDR5 WIN site-specific inhibitor OICR-9429, and WDR5 WBM site-specific inhibitor AA126. The present application first discovers that WDR5 is a key factor for regulating EBV reactivation in EBV-positive lymphoma cells, and provides the application of WDR5 inhibitors as active ingredients in the preparation of drugs for treating EBV-positive lymphoma, solving the clinical pain points of the lack of specific targets, large toxic and side effects, and high recurrence rate in the existing EBV-positive lymphoma treatment, and providing a new precise targeted treatment scheme for such diseases.
Owner:SOUTHERN UNIVERSITY OF SCIENCE AND TECHNOLOGY

Newborn pain data labeling enhancement method based on deep learning

A newborn pain data annotation enhancement method based on deep learning comprises the following steps: acquiring a newborn pain response video and extracting a key frame face image, fusing multi-scale face features and visual annotation scores by adopting a score error recognition ScorER model, and generating a heat map by utilizing a Grad-CAM algorithm to position a deviation key area and analyze a reason, so as to enhance the newborn pain data annotation. And finally generating an annotation prompt to optimize the annotation quality. According to the method, the labeling consistency and accuracy can be effectively improved, and large-scale clinical pain database construction and automatic evaluation system development are supported.
Owner:ZHEJIANG UNIV

Improved formulation of medical tissue glue for treatment of esophageal varices and injection method

PendingCN122251661ASurgical adhesivesVascular endotheliumPostoperative sepsis
The application discloses a medical tissue glue modified formula and injection method for treating esophageal varices, and relates to the field of tissue glue; the medical tissue glue modified formula and injection method for treating esophageal varices introduce polyoxyl glycol as a modifier, not only reduce the brittleness and hardness of n-butyl alpha-cyanoacrylate after polymerization, make the formed vascular embolus more flexible, significantly reduce the cutting risk of traditional hard glue block to thin-walled mucosa, thereby reduce the incidence of postoperative glue leakage ulcer and rebleeding; at the same time, polyoxyl glycol itself as a hardener can synergistically damage the vascular endothelium, accelerate thrombosis and vascular fibrosis, and improve the long-term occlusion effect; secondly, the addition of dragon's blood extract or nano-silver and other antibacterial components in the formula can actively inhibit local bacterial colonization, effectively reduce the risk of postoperative sepsis for the clinical pain points of low immunity and easy infection of patients with cirrhosis.
Owner:徐婷

An orthopedic splint fixation device

The application discloses an orthopedic splint fixing device and a use method thereof, and relates to the technical field of medical auxiliary equipment. The orthopedic splint fixing device comprises a small-arm restraint shell provided with a small-arm bandage and a large-arm restraint shell provided with a large-arm bandage, and further comprises a hinge assembly arranged between the upper part of the proximal end of the small-arm restraint shell and the lower part of the distal end of the large-arm restraint shell, so that the degree of freedom between the small-arm restraint shell and the large-arm restraint shell is between 0 and 120 degrees. Through the cooperative design of the non-invasive sleeve hoop and the multi-degree-of-freedom hinge member, the biomechanical efficiency of fracture fixation is significantly improved. The elastic compression part and the mechanical adjusting system are adopted to realize dynamic pressure adaptation. During the swelling period, the elastic connecting part can absorb local compressive stress, and after the swelling is eliminated, the initial fixing strength can be maintained, so that the clinical pain point of secondary displacement of the traditional splint can be effectively avoided.
Owner:SHANDONG BAOHUA MINGZE TRADITIONAL CHINESE MEDICINE IND DEVELOPMENT CO LTD

Endoscope biopsy needle puncture locking structure and biopsy needle

The application discloses an endoscope biopsy needle puncture locking structure and a biopsy needle, and relates to the technical field of medical devices. The endoscope biopsy needle puncture locking structure is installed on a core rod of the biopsy needle and comprises a moving ring which is provided with a hole one penetratingly arranged in the axial direction, and the moving ring is axially slidably sleeved on the core rod through the hole one. The endoscope biopsy needle puncture locking structure provided by the application realizes convenient operation of single-hand sliding adjustment of puncture depth and rotation locking through cooperation of an L-shaped sliding channel and a guide column, and significantly improves intraoperative adjustment efficiency; mechanical stop of rigid meshing of a rack and limiting convex ridges is adopted to ensure anti-vibration and anti-tension after locking, and to provide double feedback of click feeling and LOCK identification, thereby avoiding misoperation; the structure is composed of only two core parts, is simple and ingenious, and has controllable cost, and effectively solves the clinical pain points of complex operation, unreliable locking and high cost in the prior art.
Owner:JIANGSU KANGJIN MEDICAL INSTR

Intelligent drainage monitoring system based on tumor wound management

The invention relates to the technical field of medical instruments, and provides an intelligent drainage monitoring system based on tumor wound management, which comprises a drainage device, a sensing module and a processing terminal, the drainage device comprises a drainage tube, the drainage tube is a slender flexible body and is used for being inserted into a postoperative wound cavity, the far end of the drainage tube is provided with a tube opening, and the near end of the drainage tube is connected with an external negative pressure source; the drainage tube is provided with a drainage cavity, a sensing cavity and a flushing cavity; the sensing module is adjacent to a pipe opening of the drainage device and arranged in the sensing cavity, and the sensing module comprises a PH sensor, an IL-6 concentration sensor and an MMP-9 activity sensor and is used for monitoring parameter information of drainage liquid in the drainage cavity in real time; and the processing terminal is used for receiving and processing the signal from the sensing module and comprises a data processing unit, a central processing unit and an intelligent analysis unit. The method can overcome clinical pain points depending on regular observation of medical staff, subjective judgment, complication discovery lag and the like, and the early recognition ability and clinical response efficiency of the postoperative abnormal state are remarkably improved.
Owner:THE FIRST MEDICAL CENT CHINESE PLA GENERAL HOSPITAL

Clinical auxiliary decision-making system and equipment based on decision-making tree and storable medium

The invention belongs to the field of computer aided decision making, and particularly relates to a clinical aided decision making system and device based on a decision-making tree and a storable medium. The system comprises an acquisition unit used for acquiring pain information of a patient, wherein the pain information comprises whether a pain part can be positioned or not and the pain part; the decision-making unit is used for inputting the pain information into a decision-making tree model and then outputting pain causes of the patient; the decision-making unit comprises two sub-modules. The first sub-module is used for obtaining a first-level judgment result based on whether the pain part can be positioned or not. The second submodule is used for obtaining a second-level judgment result based on the first-level judgment result and the pain part; and the decision-making unit outputs the pain cause of the patient based on the second-stage judgment result. According to the method, efficient judgment of clinical pain reasons is realized, and doctors are effectively assisted in decision making.
Owner:THE SECOND XIANGYA HOSPITAL OF CENT SOUTH UNIV

Endoscope outer sleeve combined suite with adjustable inner diameter

The invention relates to an endoscope outer sleeve combined suite with an adjustable inner diameter for minimally invasive spine surgery, and belongs to the technical field of medical instruments. When a traditional small-diameter endoscope is matched with a small-diameter outer sleeve, the small-diameter outer sleeve is small in peripheral soft tissue pushing range, small in visual field range in the small-diameter outer sleeve and small in effective operation visual field, and if the traditional small-diameter endoscope is matched with a large-diameter outer sleeve, the operation visual field range can be effectively expanded. In order to solve the problem that clinical pain points which are poor in adaptability, insufficient in stability and difficult to consider the sealing performance when a small-diameter endoscope is matched with a large-diameter outer sleeve for use, the invention provides an innovative design of an endoscope and outer sleeve combined kit with the adjustable inner diameter, and adaptation is achieved by placing an inner sleeve of an inner diameter adjusting structure; according to the large-diameter endoscope, the adaptability of the small-diameter endoscope matched with the large-diameter outer sleeve is effectively achieved, a large surgical field can be obtained through the small-diameter endoscope, the surgical efficiency is improved, the surgical time is shortened, and the large-diameter endoscope has the remarkable clinical application value and the economical advantage.
Owner:DONGGUAN CHENCHENG TECHNOLOGY CO LTD

Trans-auditory meatus non-invasive continuous cranial temperature telemetering system

The invention discloses a transauditory meatus noninvasive continuous cranial temperature telemetering system, which relates to the technical field of medical monitoring equipment, and comprises an auditory meatus adaptation module, a temperature sensing module, a hardware processing module, a cranial temperature correction module, a wireless transmission module and a display early warning module, according to the method, multi-source temperature data in the auditory meatus and environmental parameters are integrated for the first time, a space-time joint feature space is constructed, time delay and space position difference of multi-source signals are eliminated through a dynamic heat conduction equation and a space-time coupling algorithm, and accurate correlation of cranial temperature is achieved. Through three technical breakthroughs of multi-point sensing fusion, anatomy adaptive earplugs and an AI auxiliary system, the major problem of in-vitro cranial temperature measurement in the medical field is solved; a traditional static single-point body temperature measurement method is broken through, dynamic continuous measurement of the human cranial temperature is provided, clinical pain points of high invasiveness, poor continuity and short endurance of existing equipment are solved, and remarkable principle innovation and technical leading are achieved.
Owner:吴明

Degradable drug sustained-release intrauterine anti-adhesion stent and preparation method thereof

The invention relates to a degradable drug sustained-release intrauterine anti-adhesion stent and a preparation method thereof, and belongs to the technical field of medical instruments, the degradable drug sustained-release intrauterine anti-adhesion stent comprises a drug-loading core layer, a sustained-release barrier layer and an antibacterial coating, the drug-loading core layer is formed by compounding a degradable high polymer material and estrogen, the degradable high polymer material is PLGA, the estrogen is 17beta-estradiol, and the sustained-release barrier layer is an anti-bacterial coating. And the loading capacity of the estrogen is 1-10wt% of the total weight of the According to the invention, the anti-adhesion purpose is achieved by physically isolating the uterine cavity wall, the regeneration of the intima is promoted in an estrogen slow release manner, the active repair effect is achieved, the PHMB coating is arranged to inhibit bacteria, and the infection prevention effect is achieved; the clinical pain points that a traditional uterine cavity anti-adhesion support needs to be taken out through a secondary operation, has no active repairing function and has the infection risk and medicine depends on systemic administration are solved in a three-in-one mode of anti-adhesion, repair promoting and anti-infection.
Owner:安徽理工大学第一附属医院(淮南市第一人民医院)

Butylphthalide Oral Solution and Its Preparation Method and Application

The present invention belongs to the field of pharmaceutical preparations, and particularly relates to a butylphthalide oral solution. The oral solution contains butylphthalide, hydroxypropyl-β-cyclodextrin and water, and is characterized in that the oral solution further comprises citric acid and / or citrate, and the mass ratio of butylphthalide, hydroxypropyl-β-cyclodextrin and water is 1:18-25:50-150. The butylphthalide oral solution of the present invention has stable quality, is safe and reliable, and has almost no pungent and throat-irritating feeling, and can be taken orally or by nasogastric feeding, solving the clinical pain points.
Owner:CHENGDU SHIBEIKANG BIOLOGICAL MEDICINE TECH CO LTD

A method for pain assessment of facial dynamic video images based on dynamic fusion module

The present invention discloses a method for assessing pain in facial dynamic video images based on a dynamic fusion module. First, the UNBC-McMaster Shoulder Pain Expression Archive dataset is subjected to data balancing processing. Then, in the pre-trained model Resnet101 network, a dynamic fusion module is obtained based on the Non-local framework improvement. An image spatial feature extraction model is established. The spatial feature information of each frame of the image is extracted through the spatial feature extraction model. The extracted feature information is then input into a long short-term memory network to extract the corresponding timing information of the facial dynamic video image. The timing information between adjacent frames is further extracted to realize the recognition of facial pain, and finally realize the automatic assessment of pain. The method of the present invention is intended to assist doctors in long-term pain monitoring and assessment of patients, provide an auxiliary means for clinical pain assessment, and has potential application prospects for assessing the pain scenarios of special patients in clinical practice.
Owner:四川脑佳科技有限公司

A 6mA modified single-stranded DNA sequence specifically binding with myh9 protein and application thereof in sepsis treatment

PendingCN122648426AStrong binding specificityNo risk of drug resistanceSignalling pathwaysSingle strand
This invention relates to the field of biomedical technology, and discloses a 6mA modified single-stranded DNA sequence that specifically binds to the MYH9 protein and its application in the treatment of sepsis; the single-stranded DNA sequence is specifically bound to the MYH9 protein. N 6 A single-stranded DNA sequence modified with 6mA-methyladenine (nucleotide sequence shown in SEQ ID NO:1) exhibits a specific adenine (A) methylation at a specific position, which allows it to be specifically recognized and bound by the MYH9 protein. The binding specificity was verified in vitro / in vivo using EMSA, biotin DNA pulldown WB assays, and MYH9-DNA IP assays. This 6mA-modified single-stranded DNA, by binding to the MYH9 protein, activates the downstream JAK1-STAT6 signaling pathway, promoting macrophage polarization towards the M2 phenotype, inhibiting excessive inflammatory responses, improving survival rates, reducing pathological damage to spleen tissue, and ameliorhythmic symptoms such as weight loss and hypothermia in septic mice, thereby exerting an anti-septic effect. This effectively addresses the clinical pain points of existing non-specific anti-inflammatory therapies and possesses significant potential for drug development.
Owner:BLOOD TRASFUSION INST CHINESE ACAD OF MEDICAL SCI

A pacifier type nebulizer for newborns

PendingCN122440945AFull Term NeonateNose
The application discloses a special pacifier type atomizer for newborns, relates to the technical field of atomizers, and aims at the clinical pain points of the existing mask type atomizer, such as poor adaptation to newborns, low cooperation degree, low drug utilization rate and hidden safety hazards, and provides a special atomization scheme, and the technical key points are as follows: the special pacifier type atomizer is composed of an atomization host, a connecting pipeline, a liquid medicine storage bin and a pacifier type mist outlet, the components are detachably and sealably connected, and can be cleaned and disinfected respectively. The host adopts a micro ultrasonic atomization structure, can output precise mist droplets with a size of 3-5 microns, and has a power of 5-10 W which can be adjusted; the mist outlet is a human engineering pacifier structure imitating breast milk, active sucking administration is realized by using the sucking reflex of newborns, and the mouth and nose are not shielded. The device improves the drug utilization rate to 75%-85%, shortens the single treatment time to 5-10 minutes, greatly improves the treatment cooperation degree, eliminates safety hazards such as suffocation and skin damage, is suitable for 1-5 kg newborns, and can be used in multiple clinical scenes such as incubators.
Owner:CHANGZHI MATERNAL & CHILD HEALTH HOSPITAL (CHANGZHI OBSTETRICS & GYNECOLOGY HOSPITAL CHANGZHI CHILDRENS HOSPITAL CHANGZHI CHILDCARE COMPREHENSIVE SERVICE CENTER)

Self-powered body position adjustment pad

ActiveCN224461927UAchieve autonomous operationimprove securityClinical painPhysical medicine and rehabilitation
The utility model relates to a kind of self-driving body position adjusting pad, including symmetrically arranged left inflatable pad, right inflatable pad and integrated air pressure regulation and control device and operating switch;Air pressure regulation and control device is connected respectively left inflatable pad and right inflatable pad by gas circuit pipeline;The air pressure regulation and control device includes air pump and solenoid valve, for controlling the inflation and exhaust of inflatable pad;Among them, operating switch is electrically connected with solenoid valve, and the operating switch is equipped with left control button and right control button, respectively independently triggers the inflation operation of left inflatable pad or right inflatable pad, and is pushed by one side inflation to promote patient body position overturning;Its advantage is shown in: the device is combined structure and pressure dispersion, individualized adjustment function optimization by symmetric inflatable pad, air pressure regulation and control device and physical operating switch, realizes patient autonomous operation, safety enhancement and comfort improvement, effectively solves the clinical pain points, such as traditional inflatable pad relies on artificial, single function, many safety hazards.
Owner:THE FIRST AFFILIATED HOSPITAL OF NAVAL MEDICAL UNIVERSITY OF CHINESE PEOPLES LIBERATION ARMY

A liver cancer thermal ablation path planning system based on deep reinforcement learning

ActiveCN121962543BClinical painNormal tissue
The present application relates to the technical field of ablation path planning, in particular to a liver cancer thermal ablation path planning system based on deep reinforcement learning. The system comprises a target and dangerous area mask generation module, a pipe distance field construction module, a thermal field prediction module, a respiratory deformation prediction module, a multi-scale feature fusion module, a behavior preference reward module, a composite reward function module and a decision output module. The present application solves the clinical pain points such as respiratory interference, dangerous area avoidance and individual adaptation, improves the precision and safety of liver cancer thermal ablation surgery, reduces normal tissue damage and complications, provides intelligent decision support for interventional therapy, and promotes the upgrading of liver cancer minimally invasive treatment to precision and intelligence.
Owner:THE THIRD MEDICAL CENT OF THE CHINESE PEOPLES LIBERATION ARMY GENERAL HOSPITAL

A thermostatic visual gynecological speculum

PendingCN122074889AImprove inspection comforteasy to operateSurgeryEndoscopesHuman bodyClinical pain
This invention discloses a constant-temperature visual gynecological speculum, relating to the field of medical device technology. It includes: a first and a second dilatation piece for examining gynecological patients; a constant-temperature mechanism to maintain a constant temperature for the first and second dilatation pieces; an expansion mechanism to assist in sliding expansion between the first and second dilatation pieces; and a limiting mechanism to limit and fix the upper connecting frame and the lower receiving frame. Through the built-in constant-temperature mechanism, specifically the heating wires located inside the first and second dilatation pieces, combined with a heat spreader plate for uniform heating, and precise temperature control by a temperature sensor, the dilatation pieces maintain a constant temperature when in contact with the human body. This completely solves the clinical pain point of traditional metal or plastic speculum, where low temperatures cause vaginal contraction, discomfort, and even obstruct the doctor's field of vision, significantly improving patient comfort during examination.
Owner:SHANGRAO HEALTH VOCATIONAL COLLEGE

Anti-bending universal bending and twisting protection assembly for pigtail drainage catheter

The invention relates to the technical field of drainage tube protection, in particular to an anti-bending universal bending and twisting protection assembly for a pigtail drainage catheter, which comprises a tube seat, a connecting seat is arranged at the upper part of the tube seat, a connector part is arranged at the upper part of the connecting seat, the connector part is connected with a catheter, and a fixed plug barrel assembly is fixedly mounted at the connector part. The fixed plug barrel assembly is fixed through a rubber inserting block, the rubber inserting block is in an L shape, a round hole is formed in the middle of the rubber inserting block, the extending length of the rubber inserting block is half of the barrel length of the fixed plug barrel assembly, a first supporting arm is fixed to the side portion of the fixed plug barrel assembly, and the first supporting arm is connected with a second supporting arm through a rotating shaft. According to the assembly, smooth drainage can be effectively guaranteed, the clinical pain point that the blue-white joint of a pigtail catheter is prone to breaking and twisting is fundamentally solved, and the unplanned rearrangement rate caused by pipeline blockage is remarkably reduced.
Owner:ZHEJIANG UNIV