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Medicinal composition with anti-inflammatory and analgesic effects, preparation method and application thereof

An anti-inflammatory and analgesic composition technology, applied in the field of pharmaceutical composition and its preparation

Active Publication Date: 2011-01-12
TIBET QIZHENG TIBETAN MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no medicine for anti-inflammation and analgesia using the pharmaceutical composition composed of urginine hydrobromide and the effective part of the unique extract

Method used

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  • Medicinal composition with anti-inflammatory and analgesic effects, preparation method and application thereof
  • Medicinal composition with anti-inflammatory and analgesic effects, preparation method and application thereof
  • Medicinal composition with anti-inflammatory and analgesic effects, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0180] Embodiment 1: pharmaceutical composition tablet of the present invention

[0181] 15g of urinadin hydrobromide, 95g of Duyiwei extract;

[0182] A. the preparation method of homogenate hydrobromide:

[0183] Take the dried Aconitum medicinal material, crush it, soak it with 10 times by weight of 75% ethanol for 144 hours, collect the soaking solution, and continue percolation with 10 times the weight of ethanol, collect the percolation solution, and combine the soaking solution and the percolation solution to obtain a mixed solution , and recover ethanol until there is no alcohol smell, add 1.5% hydrochloric acid to acidify to PH2, and filter to obtain an acidified solution; add ammonia water to alkalize the acidified solution to pH10 to obtain an alkalized solution; Dehydrate phosphorus oxide, recover chloroform, and obtain the extract; add 95% ethanol to the extract and let it stand for crystallization for 42 hours, wash with 95% ethanol, and filter to obtain urinine...

Embodiment 2

[0187] Embodiment 2: pharmaceutical composition capsule of the present invention

[0188] 95g of uricine hydrobromide, 15g of Duyiwei extract;

[0189] A. the preparation method of homogenate hydrobromide:

[0190] Take the dried Aconitum medicinal material, crush it, soak it with 5 times by weight of 95% ethanol for 276 hours, collect the soaking solution, and continue percolating with 5 times the weight of ethanol, collect the percolation solution, and combine the soaking solution and the percolation solution to obtain a mixed solution , and recover ethanol until there is no alcohol smell, add 9% hydrochloric acid to acidify to PH1, and filter the acidified solution; pass the acidified solution through a cation exchange resin, first elute with water until the eluent is colorless, then use 45% ethanol to analyze, absorb , The flow rate of washing and analysis is 3 times the bed volume / hour, collect the ethanol solution, reclaim the ethanol until there is no alcohol smell, th...

Embodiment 3

[0193] C. Mix the above unique extract with uricine hydrobromide, add conventional excipients, and make clinically or pharmaceutically acceptable capsules according to conventional processes. Embodiment 3: pharmaceutical composition powder of the present invention

[0194] 50g of uricine hydrobromide 50g of Duyiwei extract;

[0195] A. the preparation method of homogenate hydrobromide:

[0196] Take the dried Aconitum medicinal material, crush it, soak it with 20 times by weight of 65% ethanol for 96 hours, collect the soaking solution, and continue to percolate with 20 times the weight of ethanol, collect the percolation solution, and combine the soaking solution and the percolation solution to obtain a mixed solution , and reclaim ethanol until there is no alcohol smell, add 1% hydrochloric acid to acidify to PH3, and filter to obtain an acidified solution; add ammonia water to alkalize the acidified solution to pH9 to obtain an alkalized solution; Dehydrate phosphorus oxi...

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Abstract

The invention provides a medicinal composition with anti-inflammatory and analgesic effects, which is prepared by taking extracts of lappaconitine hydrobromide and lamiophlomis rotate as raw materials. By performing a pharmacological research on the interaction and the compatibility formula of the extracts of the lappaconitine hydrobromide and the lamiophlomis rotate, results show that the medicinal composition of the invention can remarkably improve the pain threshold value of a mouse compared with the single use of the extract of the lappaconitine hydrobromide or the extract of the lamiophlomis rotate; and a mouse acetic writhing test, a mouse hot tub guy test, a rat paw swelling test caused by carrageenin and a mouse external ear swelling test caused by dimethylbenzene are performed by using the medicinal composition of the invention, so that an optimum formula of the medicinal composition of the invention is obtained. The medicinal composition of the invention has remarkable anti-inflammatory and analgesic effects and wide application prospect.

Description

field of invention [0001] The present invention relates to a pharmaceutical composition and its preparation method and application, in particular to a kind of high aconitum hydrobromide which is an effective part of aconitum aconitum and a unique extract of the effective part of aconitum with anti-inflammatory and analgesic effects A pharmaceutical composition as a raw material drug and its preparation method and use. Background technique [0002] Aconitum aconitum is the dry root of Aconitum Sinomontanum Nakai, a plant of the Ranunculaceae family. It is excavated in autumn, and the fibrous roots and aerial parts are removed, and the soil is washed away and dried in the sun. Distributed in Xiaowutai Mountain, Yuxian County, Hebei Province, Shanxi, counties east of Riyue Mountain in Qinghai, Shaanxi, Gansu, Hubei, Sichuan and Guizhou provinces. Its root is poisonous, used as medicine, can reduce swelling and pain, promote blood circulation and dissipate blood stasis, expel w...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/53A61P29/00A61K31/439
Inventor 路杰黄玉兰张国霞张樱山
Owner TIBET QIZHENG TIBETAN MEDICINE
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