68 results about "Heroin" patented technology

It is a poison multiple and combination test agent box and its process method, which comprise plastic shell and test paper bar. The plastic shell comprises upper cover and down cover, wherein, the upper cover comprises specimen adding holes, test result display hole and fix mark hole; the down cover is set with flute. The test paper comprises test specimen area, test result display area and water absorption area, wherein, the test specimen area comprises glue gold and filter paper; the test result display area comprises pyroxylin film, C line control area with sheep and rabbit polyclonal antibody, test display area with heroin antigen and test display area with methyl amphetamine antigen. The water absorption area is set with absorption paper and fix mark.

Kappa opioid receptor antagonists are provided that yield significant improvements in functional binding assays to kappa opioid receptors relative to nor-BNI, and the use of these antagonists in treatment of disease states that are ameliorated by binding of the kappa opioid receptor such as heroin or cocaine addictions.

A method is provided for treating a drug-dependent individual so as to effect withdrawal from a drug of abuse, e.g., an opiate such as heroin or oxycodone, a stimulant such as cocaine, or alcohol. The method involves substitution therapy wherein a substantially nonaddicting normorphine or norcodeine derivative is substituted for the drug of abuse. The active agent has the structure of formula (I)

wherein: R is H, alkyl, or acyl; X is CH(OR′) or C═O, wherein R′ is H or acyl; α is an optional double bond, with the proviso that when α is present, then X is necessarily CH(OH), or an acid addition salt thereof, wherein preferred such agents are in a stereoisomerically pure form that corresponds to that of N-[(1R)-1-cyclopropylethyl]-normorphine (1) which melts at approximately 188° C.-189° C.

Kappa opioid receptor antagonists are provided that yield significant improvements in functional binding assays to kappa opioid receptors, and the use of these antagonists in treatment of disease states that are ameliorated by binding of the kappa opioid receptor such as heroin or cocaine addictions.

The invention is suitable for the technical field of traditional Chinese medicines, provides application of free sulfur in preparing drug treatment and rehabilitation medicaments and also provides a drug treatment and rehabilitation Chinese herbal composition of which crude drugs include a sulfur element and at least one Chinese herbal component, wherein the weight percentage of the sulfur element to the Chinese herbal component is (0.1-99):(99-0.1); the sulfur element is the free sulfur, sublimed sulfur, precipitated sulfur, sulphion or a sulfocompound. The free sulfur is applied to the preparation of the drug treatment and rehabilitation medicaments, can block the euphoria brought by drugs and can bring a long-efficient and secondary taking prevention effect. A Chinese herbal preparation prepared from the Chinese herbal composition provided by the invention has favorable curative effect for opioid drugs, excitotoxicity drugs and various controlled substances and has stronger inhibitory action for heroin dependent patients longing for the drugs, a certain inhibitory action in the euphoria generated by opioid substances, better curative effect for protracted withdrawal syndrome and action in promoting the restoring of physiological functions of organisms.

Kappa opioid receptor antagonists are provided that yield significant improvements in functional binding assays to kappa opioid receptors, and the use of these antagonists in treatment of disease states that are ameliorated by binding of the kappa opioid receptor such as heroin or cocaine addictions.

The invention relates to an application of a lead compound namely L-corydalmine (L-CDL) of isoquinoline compounds on treating diseases related with addiction. The diseases comprise drug addiction (heroin, opium, methyl amphetamine, morphine, marihuana, cocaine, and the like), nicotine addiction, and alcohol addiction, and also comprise novel drug addiction (stimulant type novel drugs) and brain damage caused by novel drugs.

The Chinese medicine preparation for stopping drug addiction is prepared with nine kinds of Chinese medicinal materials including fresh aloe leaf, kendir leaf, cordate houttuynia, balloonflower root, etc. as well as honey and medicinal acceptable additive. It is prepared into oral liquid capsule, chewing gum and other forms. It can reduce the harm of drug, such as heroin, cocain, marijuana, etc. effectively, raise immunity, regulate endorphin system and prevent re-taking in drug.

The invention discloses an antigen and a preparation method and application thereof. The antigen is a conjugate formed by connecting morphine-6-monoglutarate and a carrier protein through a covalent bond. The method for preparing the antigen comprises the following step of: conjugating the morphine-6-monoglutarate with the carrier protein so as to prepare the conjugate of the morphine-6-monoglutarate and the carrier protein, wherein the carrier protein is bovine serum albumin or hemocyanin. The antigen can stimulate an organism to generate a morphine antibody and specifically recognize the morphine and heroin. Mouse experiments prove that: a vaccine which takes the antibody as an active substance can prevent morphine relapse to a certain degree.

The present invention is asafetida extract and its pharmaceutical use, and aims at eliminating offensive odor of asafetida and providing one new use. The asafetida extract contains alpha-terpinene, 2-borneol, terpine tetraol, D-fenchol, pinocarveol, etc. and is extracted via conventional process. The asafetida extract is used in preparing drug addiction stopping medicine, and the medicine may be injection, capsule, tablet or granule.

The invention discloses a preparation process of standard products of morphine base and heroin base. The preparation process comprises the following steps: (1) carrying out methanol extraction and acid hydrolysis on a heroin sample obtained during drug control, so as to obtain a morphine crude product; (2) purifying by virtue of silica gel chromatography preparation column; (3) carrying out methanol recrystallization to obtain a morphine standard product; (4) carrying out acetylation on morphine, so as to obtain a heroin sample; and (5) recrystallizing concentrated liquid obtained in the step (4), so as to obtain a heroin base standard product, wherein the detection result of gas chromatography mass spectrometry shows that the purity of morphine base is more than or equal to 97.8% and the purity of heroin is more than or equal to 98.4%. According to a project design, all technique processes are carried out at normal temperature and normal pressure, the operation is simple, safe and environmentally friendly, and the preparation cost is low.

The invention is provided for detection of Heroin and Morphine in illicit drug samples, also for their differentiation. A liquid sample from a street sample is prepared and divided into two equal aliquots, one of them being reference sample, another being main sample. Both samples are treated with Hydrochloric acid and Sodium hydroxide, but those substances are added to the samples in the different sequence. After that the measurement of SFS of the reference sample is performed. Further the presence of specific spectral pattern of Morphine in the measured SFS of the reference, sample is detected and the value of SFS intensity at the specific spectral point is fixed (a reference value). After 15 minutes for acidification of the main sample, the analogous measurement and detection of the Morphine in the main sample are performed.

Dibenzo quinolizine compound entity has relatively low hygroscopicity and relatively high storage stability, and is applicable to preparation of analgesic, sedative, hypnotic and tranquillizing medicines, medicines for treating hypertension, arrhythmia and functional dyspepsia, stopping cough, resisting schizophrenia and heroin and other drug dependence, reversing tumor cell drug resistance and delaying or reducing myocardial ischemia reperfusion injury, calcium antagonists, and medicines for protecting the liver and preventing visceral implicated reaction and other effects, which are applied to humans or animals.

The invention discloses an antigen and the application thereof. The antigen provided by the invention is shown as the formula I. The antigen takes morphine-6-glutaric acid monoester as hapten, the hapten and carrier protein are connected through a 6-carbon-atomic-link-shaped connecting arm of N-(Epsilon-trifluoro acetyl hexanoyl oxygen) succinimide ester (TFCS) derivant, and the distance between a morphine skeletal structure and the carrier protein is increased. The antigen can irritate a body to produce high-concentration morphine antibody, the duration of the antibody is long, and the antibody can be specifically bound with morphine and heroin and can prevent recrudescence of a heroin seeking behavior induced by ignition of heroin for a long time.

The invention provides a capsule for drug addiction treatment and a preparation method thereof. The capsule comprises the following components in parts by weight: 3 to 10 parts of campsis grandiflora, 3 to 10 parts of berba aristolochiae mollissima, 3 to 10 parts of stasis blocking medicine, 20 to 30 parts of hedyotis diffusa, 8 to 10 parts of sculellaria barbata, 10 to 15 parts of phryma leptostachya, 3 to 6 parts of celastrus orbiculatus, 20 to 30 parts of herba pteridis multifidae, 10 to 30 parts of zuobanteng (traditional Chinese medicine), 10 to 20 parts of selfheal, 2 to 6 parts of baizhongzhi (traditional Chinese medicine), 10 to 12 parts of blackberry lily, 10 to 15 parts of oldenlandia chrysotricha chun, 8 to 15 parts of herba violae, 8 to 15 parts of dandelion, and 6 to 8 parts of wikstroemia indica, amounting to 16 medicines. The preparation method of the capsule for drug addiction treatment comprises the steps of processing, concentrating, extracting and refining. The capsule for drug addiction treatment is mainly used for detoxicating, cleaning, eliminating and de-addicting a person taking heroin, amphetamin chloride, marihuana, dancing outreach and various addiction drugs, and is safe and convenient.

The invention discloses a hyperspectrum-based methamphetamine, heroin and hemp detection method and belongs to the field of drug detection. According to the method, a central processing module is adopted; the input end of the central processing module is connected with an image acquisition module; the output end of the central processing module is connected with an information display module; theconnecting end of the central processing module is connected with an image storage module and a model establishing module; and the output end of the central processing module is connected with an intelligent analysis module. According to the method of the invention, based on overall design, a series of operations such as impurity removal, correction and brightness adjustment are performed on an image through the central processing module, so that a comprehensive hyperspectrum image can be formed, and a model is built; the built model is optimized with an image optimization unit, so that the built model is more perfect. The method can be used for more accurately and effectively detecting objects such as methamphetamine, heroin and hemp on the whole, so that more comprehensive detection information is obtained.

The invention relates to an external-use Chinese medicament for fighting drugs, which comprises a main medicine and an adjuvant; the raw materials of the main medicine comprise the following crude medicines according to parts by weight: 1pbw to 15pbw of scorpion, 8pbw to 40pbw of radix aconiti agrestis, 20pbw to 50pbw of aconitum Chinese paxton, 25pbw to 40pbw of gecko, 15pbw to 30pbw of nux vomica, 40pbw to 80pbw of bloodsuckers, 35pbw to 90pbw of Chinese gall, 35pbw to 90pbw of radices euphorbiae kansui liou, 8pbw to 30pbw of brimstone, 3pbw to 25pbw of cantharis, 2pbw to 8pbw of borneol (borneolum syntheticum), 1pbw to 5pbw of camphor, 10pbw to 90pbw of dung beetles, 4pbw to 28pbw of musk and 250pbw to 500pbw of Sailong bone; the raw materials of the adjuvant comprise 15pbw to 20pbw of flos daturae, 8pbw to 12pbw of liquorice, 15pbw to 20pbw of safflower and 300pbw to 800pbw of Shanxi mature vinegar. The invention also relates to a preparation method of the external-use Chinese medicament. The external-use Chinese medicament is applied to the projection position of encephalic conarium inside in the occipital skin of a patient, utilizes the principles of using poison as an antidote to poison and removing toxin by normalizing meridian to help the patient withdraw addicting to narcotic drugs, such as heroin, methamphetamine, marijuana or dancing outreach, and the like.

The present invention is aimed at providing an opioid antagonist compound and preparation method thereof, and its medical use. The medical use for opioid antagonists such as the compound of formula (I) (shown below) include complete or partial reversal of narcotic depression, including respiratory depression, induced by opioids including natural and synthetic narcotics, such as heroin, fentanyl, oxycodone, hydrocodone, morphine, propoxyphene, methadone and certain narcotic-antagonist analgesics, such as nalbuphine, pentazocine and butorphanol. An opioid antagonist may also be useful as an adjunctive agent to increase blood pressure in the management of septic shock. Further, opioid antagonists also have been shown to reduce the craving for alcohol.

The invention relates to a method for rapid identification and composition analysis of drugs. The method comprises the steps of: taking a cotton swab dipped in methanol as an extraction medium, and swabbing the surface of a solid by means of the cotton swab to extract main components therein; then inserting the cotton swab into a reagent bottle containing methanol for simple washing and shaking, so as to dilute the amount of drugs dipped on the cotton swab, or directly painting on a sample injection cloth by using the cotton swab without dilution; and finally, using a portable ion trap mass spectrometer as a detection instrument, and identifying the suspected drug solid as opium through direction mass spectrometry and tandem mass spectrometry. The method is suitable for the rapid detectionof drug compositions in opium, and is suitable for the rapid detection of compositions in drugs of other types such as methamphetamine, heroin and marijuana. The method has the advantages that the sample pretreatment time is less than 5 min, the mass spectrometric detection time is less than 2 s, and the detection limits of five kinds of drug samples are all less than 10 ng, thereby greatly contributing to the on-site investigation, seizing and identification of drugs.