Discriminating method for heroin origins

A discrimination method, heroin technology, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of complex discrimination process and great influence

Inactive Publication Date: 2015-02-18
公安部禁毒情报技术中心
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  • Claims
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AI Technical Summary

Problems solved by technology

[0004] In the existing literature on the use of neutral or acidic impurities for the classification and identification of heroin sources, no chemometric method is used. The basis for the identification is mainly based on the types of characteristic neutral or acidic impurities contained in heroin samples and Relative content, so the identification process is more complicated, relying more on experience, and the determination results are greatly affected by human factors

Method used

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  • Discriminating method for heroin origins
  • Discriminating method for heroin origins
  • Discriminating method for heroin origins

Examples

Experimental program
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Effect test

Embodiment 1

[0059] For heroin sample S1 with a known source, firstly, 25 kinds of neutral or acidic impurities in sample S1 were detected by ultra-high performance liquid chromatography-tandem quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF), and each For the values ​​of the peak areas of neutral or acidic impurities, see Table 4 for details, where A 1 -A 25 Corresponds to impurities numbered 1-25 in Table 2.

[0060] Ultra-high performance liquid chromatography-tandem quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF) simultaneously determines the method for 25 kinds of neutral or acidic impurities in heroin comprising the following steps:

[0061] (1) Extraction of neutral or acidic impurities to be tested in heroin samples

[0062] Weigh 100mg of "Southeast Asia" heroin sample, place it in an 8mL glass centrifuge tube, pipette 2mL of the acidified solvent into the glass centrifuge tube with a 5mL bottle top pipette, the acidified solvent is: 0.25M H 2 SO 4 Solution, u...

Embodiment 2

[0074] For the heroin sample S2 with a known source, the 25 neutral or acidic impurities in the sample S2 were detected by ultra-high performance liquid chromatography-tandem quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF) method firstly, and each For the values ​​of the peak areas of neutral or acidic impurities, see Table 4 for details.

[0075] Example 2 differs from Example 1 only in that the samples are known to originate from Southwest Asia.

[0076] Substitute the values ​​of the 25 neutral or acidic impurities in the S2 sample into the discriminant function t, and obtain t(S2)=-5.116; since -6

[0077] Table 4 List of peak area values ​​of 25 neutral or acidic impurities in two heroin samples (S1 and S2)

[0078]

A 1

A 2

A 3

A 4

A 5

A 6

A 7

A 8

A 9

S1

14879

21067

2281

195

4547

424

44380

2834 ...

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Abstract

The invention provides a discriminating method for heroin origins based on neutral or acidic impurities and partial least-squares discriminant analysis (PLS-DA), which is suitable for discriminating affiliation of heroin in two origins: southeast Asia and southwest Asia. The method comprises the following steps: firstly, putting forward a discriminating function of PLS-DA of the heroin origins; detecting peak area numerical values of independent variables of 25 neutral or acidic impurities in a heroin sample, and substituting the peak area numerical values into the PLS-DA discriminating function; calculating the numerical value t of the obtained discriminating function; when t is greater than 0 and less than 6, judging that the heroin origin is southeast Asia; and when t is greater than -6 and less than 0, judging that the heroin origin is southwest Asia.

Description

technical field [0001] The invention relates to the technical field of identifying the source of heroin, in particular to a method for identifying the source of heroin based on neutral or acidic impurities and partial least squares discriminant analysis (PLS-DA). Background technique [0002] As one of the most common and most consumed drugs in China, heroin is extremely harmful to society, so the source of heroin has attracted people's attention. The discriminant analysis of the source of heroin will help analyze the entry channels and trafficking routes of heroin, and can provide data support for the strategic evaluation of heroin drug situation in the country or a certain region, as well as for the policy formulation and intelligence research and judgment of the drug control department. [0003] Heroin, also known as diacetylmorphine, is a semi-synthetic drug produced by acetylation of morphine, the main alkaloid in opium. During the illegal processing of heroin, a large...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/88
Inventor 刘翠梅花镇东白燕平
Owner 公安部禁毒情报技术中心
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