Method for rapidly identifying monoacetylmorphine and morphine in hair

A technology of monoacetylmorphine and hair, which is applied in the field of rapid identification of monoacetylmorphine and morphine in hair, can solve the problems of high cost, use of a large amount of liquid nitrogen, and long time-consuming freeze-grinding technology to achieve strong selectivity and high sensitivity Effect
CN103207242BActive Publication Date: 2015-03-25ACADEMY OF FORENSIC SCIENCE
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ACADEMY OF FORENSIC SCIENCE
Publication Date
2015-03-25

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Abstract

The invention provides a method for rapidly identifying monoacetylmorphine and morphine in hair. The method sequentially comprises the following steps: 1, placing hair to be detected, an extract liquid, internal standard morphine-d3 and a billiard ball in a crusher, and carrying out micro-crushing treatment; 2, centrifuging a mixture obtained after the micro-crushing treatment; and 3, taking the supernatant of the centrifuged mixture, and carrying out liquid chromatography-tandem mass spectrometry analysis of the supernatant. The method for rapidly identifying monoacetylmorphine and morphine in hair can realize the simple and rapid separation and purification of monoacetylmorphine and morphine molecules in a complex biological matrix, has the advantages of strong specificity, strong selectivity and high sensitivity, can be used for detecting a practical drug addict hair sample, and can also be used for identifying and detecting heroin addict related cases in the forensic toxicological analysis field.
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Description

technical field

[0001] The invention relates to a rapid identification method, in particular to a method for applying micro-pulverization extraction technology and liquid chromatography tandem mass spectrometry technology in analyzing monoacetylmorphine and morphine in hair. Background technique

[0002] According to the "2010 World Drug Report", the total number of heroin addicts in my country ranks first in the world, which is one of the serious social problems at present. Heroin is well absorbed by smoking and injection, and can penetrate the blood-brain barrier in a large amount and take effect quickly. After entering the human body, heroin is rapidly metabolized into 6-monoacetylmorphine under the action of blood lipase, and then further metabolized into morphine in the liver and combined with glucuronic acid. The metabolites of heroin in urine include 6-monoacetylmorphine, free morphine, morphine-3-glucuronic acid conjugates, morphine-6-glucuronic acid conjugates and ...

Claims

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