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Asafetida extract and its pharmaceutical use

A technology of extracts and disulfides, applied in the direction of drug combinations, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve problems such as side effects, poisoning, and drug dependence

Inactive Publication Date: 2004-11-24
王彦丁 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These drugs are also narcotic drugs or psychotropic drugs, which can cause drug dependence, so they are also a kind of drug, and long-term use can cause poisoning and bring many side effects

Method used

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  • Asafetida extract and its pharmaceutical use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0076] Ferulicum ferulae extract of the present invention, use ferulicum ferulae of Xinjiang or Iranian, Afghan ferulica as raw material, adopt common steam distillation method to prepare. Measured in parts by weight, take 0.1 to 20 parts of Xinjiang Ferulicum or Iran or Afghan Ferulicum, add 0.1 to 80 parts of purified water, carry out steam distillation, control the temperature at 105.5 to 108 ° C, collect 0.2 to 400 parts of the first distillate, Further redistillation is carried out, and 0.1 to 200 parts of the distillate are collected to obtain milky white liquid Ferulicum extract.

[0077] The above-mentioned ferulicum extract is a supersaturated solution of volatile oil, with a pH value of 4 to 5.7, which is sent to the Analysis and Testing Center of the Chinese Academy of Sciences, and detected by GC-MS. The main active ingredients and the content in 100ml (1ml: 1g) are: α -Terpinene 144mg, 2-Camphenol 160mg, Terpine 4-ol 125mg, D-Fenyl Alcohol 93mg, Pincarveol 88mg, D...

Embodiment 2

[0082]Ferulicum extract of the present invention, adopts common azeotropic distillation method to prepare. Take 500g of Xinjiang Ferulicum or Iranian or Afghan Ferulicum, add 8000ml of purified water, carry out azeotropic distillation at a temperature of 105-108°C, collect 4000ml of the first distillate, and then carry out redistillation. 1000ml. Ferulicum extract is milky white liquid supersaturated solution of volatile oil, pH value is 4-5.7, main ingredients: α-terpinene, 2-camphor, terpineol 4-ol, D-fenzyl alcohol, rosin Apiol, dimethyl disulfide, dimethyl trisulfide, methyl-propenyl-disulfide, 2,2-dimethylthiopropane, 1,2-diethylthiopropane, N , N-dimethylthioformamide, propenyl-butyl-disulfide.

[0083] The aforesaid ferulic extract is used to prepare a kind of antidote drug ferulic injection, which is prepared by a conventional method. Add 5g of polysorbate 80 (for medicinal use) to 1000ml of Ferulicum extract, stir for 5min, add 7g of sodium chloride (for injection)...

Embodiment 3

[0085] Ferulicum extract of the present invention, adopts common vacuum distillation method to prepare. Take 600g of Xinjiang Ferulicum or Iranian or Afghan Ferulicum, add 9000ml of purified water, and control the conditions at 105-108°C / 1300-1400Pa, carry out negative pressure distillation, collect 4000ml of initial distillate, and then carry out redistillation, and collect the redistillate Ferulicum extract 1000ml. Physicochemical property and main component of Ferulicum extract are identical with embodiment 2.

[0086] The aforesaid ferulic extract is used to prepare a kind of antidote drug ferulic injection, which is prepared by a conventional method. Add 5g of polysorbate 80 (medicinal) to 1000ml of Ferulicum extract, stir for 5min, add 7g of sodium chloride (for injection), add water for injection to 1000ml, continue stirring for 5min, filter through 0.22μm micromembrane After that, fill and seal the ampoules, and sterilize at 100°C for 30 minutes to obtain Ferulic Inj...

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Abstract

The present invention is asafetida extract and its pharmaceutical use, and aims at eliminating offensive odor of asafetida and providing one new use. The asafetida extract contains alpha-terpinene, 2-borneol, terpine tetraol, D-fenchol, pinocarveol, etc. and is extracted via conventional process. The asafetida extract is used in preparing drug addiction stopping medicine, and the medicine may be injection, capsule, tablet or granule.

Description

technical field [0001] The present invention relates to the extract of the original traditional Chinese medicine Ferulicum and the pharmaceutical application of the Ferulic extract. Background technique [0002] Asafoetida is a natural plant secretion. "Pharmacopoeia of the People's Republic of China" 2000 edition one 148 pages records: Ferulica is bitter, pungent and warm in nature and belongs to the spleen and stomach meridians. Dispelling stagnation, dispelling cold, killing parasites, used for stagnation of meat, congestion, mass in the abdomen, abdominal pain caused by parasites. "National Compilation of Chinese Herbal Medicine" Volume 2 People's Health Publishing House, 1978, page 318 records: Ferulicum is pungent in nature and slightly warm. Dispelling stagnation, killing insects, dispelling cold. Indications for insect accumulation, abdominal mass, abdominal distension, malaria, dysentery, and prevention of measles. The traditional use of asafoetida is to decoct i...

Claims

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Application Information

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IPC IPC(8): A61K31/16A61P25/36C07B63/00
Inventor 王泽民
Owner 王彦丁
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