Probenecid sustained-release tablet and preparation method

A technology of probenecid and sustained-release tablets, which is applied in the field of medicine, can solve the problems of reduced curative effect, inconvenient administration, and poor patient compliance, and achieve the effects of simple formula, fast drug application, and increased compliance

Active Publication Date: 2015-08-12
李超
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is relatively inconvenient to take, and the patient's compliance is poor, and forgetting to take it will reduce the curative effect, espec

Method used

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  • Probenecid sustained-release tablet and preparation method
  • Probenecid sustained-release tablet and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] A probenecid sustained-release tablet, the components and parts by weight of the sustained-release tablet include: 45 parts of probenecid, 32 parts of sodium bicarbonate, 23 parts of sucrose pills, 4 parts of ethyl cellulose, and 0.4 part of castor oil , 0.2 parts of hypromellose, 12 parts of compressible starch, 0.8 parts of magnesium stearate, 17 parts of dry starch, and 3 parts of hydroxypropyl methylcellulose.

[0034] A preparation method of probenecid sustained-release tablets, the specific steps comprising:

[0035] 1) Material preparation: prepare materials according to the components and parts by weight of a probenecid sustained-release tablet, wherein sodium bicarbonate is pulverized through a 100-mesh sieve, and fillers, lubricants, and disintegrants are pulverized through a 80-mesh sieve;

[0036] 2) Preparation of the drug-containing pellet core: adopt the drug-applying process at the bottom of the fluidized bed, dissolve probenecid with 95% alcohol to prep...

Embodiment 2

[0042] A probenecid sustained-release tablet, the components and parts by weight of the sustained-release tablet include: 40 parts of probenecid, 30 parts of sodium bicarbonate, 20 parts of microcrystalline cellulose pellets, 3 parts of polyethylene glycol, glycerin 0.3 parts of ester, 0.1 parts of polyacrylic resin, 10 parts of microcrystalline cellulose, 0.5 parts of micropowder silica gel, 15 parts of dry starch, and 2 parts of hydroxypropyl cellulose.

[0043] A preparation method of probenecid sustained-release tablets, the specific steps comprising:

[0044]1) Material preparation: prepare materials according to the components and parts by weight of a probenecid sustained-release tablet, wherein sodium bicarbonate is pulverized through a 100-mesh sieve, and fillers, lubricants, and disintegrants are pulverized through a 80-mesh sieve;

[0045] 2) Preparation of the drug-containing pellet core: adopt the drug-applying process at the bottom of the fluidized bed, dissolve p...

Embodiment 3

[0051] A probenecid sustained-release tablet, the components and parts by weight of the sustained-release tablet include: 50 parts of probenecid, 35 parts of sodium bicarbonate, 35 parts of starch pellets, 5 parts of polyethylene, 0.6 part of succinate, 0.3 parts of polyethylene glycol, 15 parts of microcrystalline cellulose, 1.0 parts of talcum powder, 30 parts of sodium carboxymethyl starch, and 5 parts of hydroxypropyl cellulose.

[0052] A preparation method of probenecid sustained-release tablets, the specific steps comprising:

[0053] 1) Material preparation: prepare materials according to the components and parts by weight of a probenecid sustained-release tablet, wherein sodium bicarbonate is pulverized through a 100-mesh sieve, and fillers, lubricants, and disintegrants are pulverized through a 80-mesh sieve;

[0054] 2) Preparation of the drug-containing pellet core: adopt the drug-applying process at the bottom of the fluidized bed, dissolve probenecid with 98% alc...

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Abstract

The invention discloses a probenecid sustained-release tablet and a preparation method. The probenecid sustained-release tablet is composed of, by weight, 40-50 parts of probenecid, 30-35 parts of sodium bicarbonate, 20-25 parts of core pellet, 3-5 parts of sustained-release material, 0.3-0.6 part of plasticizer, 0.1-0.3 part of porogen, 10-15 parts of filler, 0.5-1.0 of lubricating agent, 15-20 parts of disintegrant and 2-5 parts of coating material. The preparation method includes the steps of material preparation, preparation of pellet containing core, preparation of sustained-release pellets, tabletting and coating. Sodium bicarbonate is added in the formula, so that urate can be prevented from forming urinary stone in the urinary tract by taking the probenecid sustained-release tablet with a lot of water for treating chronic gout. Sodium bicarbonate can neutralize excessive gastric acid and has stomach-invigorating and antiacid effect when improving effect of penicillins. The probenecid sustained-release tablet is taken 1-2 times a day, so that compliance of patients is increased.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a probenecid sustained-release tablet and a preparation method thereof. Background technique [0002] Hyperuricemia (HUA) refers to hyperuricemia when the blood uric acid level on an empty stomach exceeds 420 μmol / L for men and 360 μmol / L for women on two different days in a normal purine diet. Uric acid is the terminal metabolite of human purine compounds. Disorders of purine metabolism lead to hyperuricemia. According to reports on the prevalence of hyperuricemia in various places in recent years, there are currently about 120 million hyperuricemia patients in my country, accounting for about 10% of the total population. trend. [0003] Probenecid is a white crystalline powder, odorless, slightly bitter taste, soluble in acetone, slightly soluble in ethanol or chloroform, almost insoluble in water, soluble in dilute sodium hydroxide solution, almost insoluble in ...

Claims

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Application Information

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IPC IPC(8): A61K33/00A61K9/26A61K9/36A61P19/06A61P13/04A61P1/00A61P1/04A61K31/195A61K31/43
Inventor 夏征梅
Owner 李超
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