43 results about "Renal Hypertensions" patented technology

Sympathetic nerves run through the adventitia surrounding renal arteries and are critical in the modulation of systemic hypertension. Hyperactivity of these nerves can cause renal hypertension, a disease prevalent in 30-40% of the adult population. Hypertension can be treated with neuromodulating agents (such as angiotensin converting enzyme inhibitors, angiotensin II inhibitors, or aldosterone receptor blockers), but requires adherence to strict medication regimens and often does not reach target blood pressure threshold to reduce risk of major cardiovascular events. A minimally invasive solution is presented here to reduce the activity of the sympathetic nerves surrounding the renal artery by locally delivering neurotoxic or nerve-blocking agents into the adventitia. Extended elution of these agents may also be accomplished in order to tailor the therapy to the patient.

Sympathetic nerves run through the adventitia surrounding renal arteries and are critical in the modulation of systemic hypertension. Hyperactivity of these nerves can cause renal hypertension, a disease prevalent in 30-40% of the adult population. Hypertension can be treated with neuromodulating agents (such as angiotensin converting enzyme inhibitors, angiotensin II inhibitors, or aldosterone receptor blockers), but requires adherence to strict regimens and often does not reach target blood pressure threshold to reduce risk of major cardiovascular events. A minimally invasive solution is presented here to reduce the activity of the sympathetic nerves surrounding the renal artery by locally delivering neurotoxic or sympathetic nerve-blocking agents into the adventitia. Extended elution of these agents may also be accomplished in order to tailor the therapy to the patient.

Human receptor selective atrial natriuretic factor variants containing various substitutions, especially G16R, show equal potency and binding affinity for the human A-receptor but have decreased affinity for the human clearance or C-receptor. These ANF variants have natriuretic, diuretic and vasorelaxant activity but have increased metabolic stability, making them suitable for treating congestive heart failure, acute kidney failure and renal hypertension.

The invention discloses a medicine for treating hypertension. The medicine comprises Ligusticum wallichii, uncaria, Eucommia ulmoides, unprepared rehmannia root, Rhizoma Coptidis, Radix Scutellariae, Chinese angelica, Chinese Taxillus Twig, Radix Paeoniae Rubra, Radix Salviae Miltiorrhizae, haw, Achyranthes bidentata, Radix Puerariae, Cortex Moutan, spine date seed, Semen Brassicae, Radix Astragali, prepared rehmannia root, white peony root, Tortoiseshell, Cortex Lycii, rhizoma gastrodiae, chrysanthemum, Spica Prunellae and Mythic Fungus according to a proper ratio. The medicine of the invention has curative effects on primary hypertension, renal hypertension and secondary hypertension, the effective rate of the medicine on hypertension is 100%, the cure rate is 98%, and the medicine which has the advantages of convenient oral administration, no toxic side effect, difficult recurrence after curing, fast effectiveness after the medicine administration and easily available and cheap medicinal material is an ideal medicine for treating above hypertension diseases.

The present invention relates generally to a method for the treatment of renal failure or renal hypertension and, more particularly, for improving the recovery from acute renal failure or renal hypertension by treatment with activators of soluble guanylate cyclase or stimulators of guanylate cyclase.

A Chinese medicine in the form of ointment for treating uremia, renal hypertension and hyperlipomia is prepared from 20 Chinese-medicinal materials including Chinese rhubarb, forsythia fruit, Dragon's bone, red sage root, honeysuckle flower, etc. Its advantages are high effective rate (more than 98%), quickly and durably taking its effect, no recurrence and low cost.

The invention relates to a preparation method and an application of an effective part of dracocephalum heterophyllum benth. The method comprises the steps that an aboveground part of the dracocephalum heterophyllum benth is smashed, extracted by an organic solvent, namely alcohol, and subjected to macroporous resin separation and purification to form the effective part of the dracocephalum heterophyllum benth. A preliminary activity screening test proves that the effective part of the dracocephalum heterophyllum benth obtained by the method has functions of lowering renal hypertension and rat blood pressure, and enhancing diastole and systole, and can also effectively prevent and treat hypertension complications including myocardial hypertrophy, renal injuries and vascular endothelial injuries. The method is simple in technology, low in production cost, and easy to control, and does not require high temperature or high pressure equipment, and the quality of the effective component is stable.

The invention relates to a medicinal composition using Efonidipine as the active constituent, the process for preparation and use thereof, which also contains pharmaceutically acceptable auxiliary materials, and can be used for the treatment of primary hypertension, severe hypertension and renal hypertension. The composition can be prepared into tablets, capsules, dispersible tablets, soft capsules, chewable tablets, buccal tablets, buccal tablets, dried suspending agents, and dripping pills.

The invention relates to a Chinese medicinal preparation for treating kidney diseases and process for preparation, wherein the medicament is prepared from the following Chinese medicinal herbs (by weight portion): red sage root 20-30 parts, barbat skullcap 5-10 parts, safflower 5-10 parts, Japanese felt fern leaf. 5-10 parts, honeysuckle flower 5-10 parts, rheum officinale 10-15 parts, capsule of weeping forsythia 5-10 parts, licorice root 3-6 parts, poria cocos wolf 10-15 parts, panax notoginseng saponins 1-1.5 parts.

A method of reducing renal hypertension applied for electrically stimulating a target zone of an organism having a symptom of renal hypertension by using an electronic stimulation device. The electronic stimulation device comprises at least one electronic stimulation unit. The electronic stimulation unit includes at least one first electrode and at least one second electrode. The method includes the following steps. The electrical stimulation unit is placed near the target zone. The electrical stimulation unit generates an electrical stimulation signal and the electrical stimulation signal is introduced to the target zone so as to stimulate the target zone. An electric field is generated between the first electrode and the second electrode and covers the target zone. The strength of the electric field ranges from 100V / m to 1000V / m.

An electronic stimulation device is adapted for electrically stimulating a target zone of an organism. The electronic stimulation device comprises at least one electronic stimulation unit. The electronic stimulation unit includes at least one first electrode and at least one second electrode. The electronic stimulation unit transmits a first electrical stimulation signal. A electric field is generated between the first electrode and the second electrode according to the first electrical stimulation signal. The strength of the electric field covering the target zone ranges from 100 V / m to 1000V / m. The target zone is dorsal root ganglion, spinal cord, dorsal root, dorsal honr, ventral root, or nerve on a neurotransmission path resulting in renal hypertension.

The invention discloses a compound traditional Chinese medicine for treating hypertension. The compound traditional Chinese medicine is prepared by the step of carrying out extraction separation on raw materials including uncaria rhynchophylla, ligusticum wallichii, angelica sinensis, rauvolfia verticillate and apocynum venetum with 0-75% ethanol and is prepared into a certain dosage form. The five drugs used together have the effects of calming liver wind and relieving dizziness, nourishing yin and invigorating pulse and are applied to patients suffering from yin deficiency and yang excess and venation stasis of hypertension symptoms. Pharmacodynamic studies show that the compound traditional Chinese medicine can obviously reduce the systolic pressure and the diastolic pressure of spontaneous hypertension and renal hypertension model animals and the antihypertensive effect is longlasting. Clinical research results show that the compound traditional Chinese medicine can effectively improve various traditional Chinese medicine symptoms of the patients suffering from yin deficiency and yang excess and venation stasis of hypertension and reduce the blood pressure of the patients without obvious adverse drug reaction. The compound traditional Chinese medicine can be prepared into a medically acceptable oral solid preparation such as a tablet, a capsule (a soft capsule or a hard capsule), granules and other dosage forms, is used for treating hypertension and is safe, effective and convenient to use.

The invention discloses a traditional Chinese medicine composition for treating hypertension, which takes Ligusticum wallichii, uncaria and radix ophiopogonis as raw materials. The test result shows that the Ligusticum wallichii, the uncaria and the radix ophiopogonis have excellent interaction after compatibility of medicines, and can obviously lower the systolic pressure and the diastolic pressure of model animals with spontaneous hypertension and renal hypertension, and pressure reduction effect is long-lasting. The composition has the advantages of reasonable compound prescription and appropriate compatibility proportion, has the function on calming liver wind, nourishing yin and invigorating the circulation of blood and has definite curative effect on hypertension patients with the symptom of yin deficiency and yang excess as well as blood stasis obstructing the collaterals. The composition can be prepared into medically-acceptable solid oral preparations, such as tablets, capsules (soft capsules or hard capsules), granules and the like, can be used for treating hypertension, and is safe, effective and convenient to use.

Methods and compositions for the treating chronic renal hypertension in a subject comprising administering a therapeutically effective amount of at least one nitroxide-containing composition to the subject, particularly 4-hydroxy-2,2,6,6-tetramethyl-1-piperidine-1-oxyl (Tempol).

The invention relates to an application of Chinese yarn glycoprotein in preparation of a medicament for treating nephritis and renal hypertension. Selection and verification are carried out by an animal test to prove that the Chinese yarn glycoprotein has the effects of treating glomerulonephritis and renal hypertension and has high safety. The Chinese yarn glycoprotein is derived from natural plants, medicine sources are sufficient, extraction and preparation method is simple and practicable, and the prepared medicament can be prepared into multiple dosage forms such as capsules, tablets, granules and oral liquid.

The invention discloses compound traditional Chinese medicine for treating hypertension. The compound traditional Chinese medicine is prepared from the raw materials of rhizoma gastrodiae, uncariae ramulus cum uncis, rhizoma chuanxiong, rauwolfia root, rhizoma pinelliae praeparatum and the like, and the raw materials are extracted and separated by a 0 to 75% ethanol water solution to be prepared into certain dosage forms. The compound traditional Chinese medicine has the effects of suppressing hyperactive liver for calming endogenous wind and eliminating phlegm by cooling and can be applied toprimary hypertension or refractory hypertension liver fire hyperactivity and phlegm heat accumulation patients. Pharmacodynamic study shows that the compound traditional Chinese medicine can obviously reduce systolic pressure and diastolic pressure of spontaneous hypertension and renal hypertension model animals and has a durable blood pressure lowering effect. Clinical research results show thatthe medicine disclosed by the invention can effectively improve all traditional Chinese medicine symptoms of the hypertension liver fire hyperactivity and phlegm heat accumulation patients, can effectively reduce blood pressure of the patient and has no obvious adverse drug reaction. The compound traditional Chinese medicine can be applied to treating hypertension, is safe and effective and has convenience in use; clinical effects and pharmacodynamic study prove that the compound traditional Chinese medicine disclosed by the invention has the functions of suppressing hyperactive liver for calming endogenous wind and eliminating phlegm by cooling and is effective dedicated medicine for treating hypertension.

The invention discloses kumquat essential oil and a preparation method and application thereof. The kumquat essential oil is a pure natural substance extracted from kumquat fruits. The kumquat essential oil is obtained through dry steaming extraction, main active ingredients and content in the kumquat essential oil are measured by utilizing GC-MS, and then a hypertension animal model test is established, so that the kumquat essential oil and the active ingredients thereof are proved to be capable of obviously reducing vasoconstriction pressure and regulating vasodilatation factors such as angiotensin II and the like and also capable of relieving target organ damage caused by hypertension; and a cell test proves that the kumquat essential oil is capable of regulating the angiotensin II to induce HUVEC cell viability. Therefore, the kumquat essential oil has good prevention and treatment effects on renal hypertension.

The invention discloses a preparation method of a medicine for treating hypertension and relates to the preparation method of the medicine for treating hypertension. The preparation method comprises the following steps of: firstly, adding ethanol to soak waternut culm, heating up the mixed solution until the mixed solution is reflowed, filtering the mixed solution, collecting the filtrate for future use, carrying out reflux extraction on the filter residue twice, combining the filtrates, filling the combined filtrate to a rotary evaporator, and recycling the ethanol under reduced pressure; and secondly, putting residual thick paste in a rotary bottle to an evaporating dish, drying the thick paste in a water bath, putting the dried thick paste to a drying box, obtaining the ethanol-extraction substance dry paste by drying, pulverizing the dry paste to obtain granular powder with active ingredients, namely completing the preparation process. According to the preparation method disclosed by the invention, the hypertension ethanol extract has a good effect for treating renal hypertension and better safety, so that a new scheme is provided for developing the traditional Chinese medicine neurogenic hypertension drug, and a novel strategy is provided for treating the hypertension. The prepared medicine for treating the hypertension can be used for effectively reducing blood pressure and reducing systolic pressure more remarkably relative to diastolic pressure, is free of side effects, not capable of damaging visceral organs after being taken for a long time, small in drug dependence and safer in drug use.

A surgical apparatus for delivering fluid to treat renal hypertension including an elongated member having a distal tip and a plurality of openings formed in a sidewall proximal of the distal tip. A plurality of fluid delivery members are movably positioned in the elongated member, each of the fluid delivery members having a lumen and at least one opening communicating with the lumen for delivering fluid extravascularly. An actuator is operatively associated with the fluid delivery members, the actuator actuable to a first position to move the fluid delivery members from a retracted position within the elongated member to a deployed position extending radially with respect to the elongated member. A balloon is expandable radially from the elongated member to seal the renal artery during application of fluid through the fluid delivery members.

The invention discloses bepiastine. A formula consists of the following components by weight: 666g of bear gall powder and 3,200g of mile swertia, wherein a mile swertia raw material is required to be taken from a nationally-specified place, i.e., Mile in Yunnan Province; and the content of bear gall powder is required to reach a national medicament standard. A preparation method comprises the following steps of: extracting mile swertia twice by taking water as a solvent at the temperature of 80-90 DEG C, every time for 4 hours; combining extracting solutions; filtering with a micro water filter membrane; concentrating a filtrate in vacuum at a low temperature into thick paste of 1.30-1.35 (50 DEG C); drying into dry extract under reduced pressure; smashing the bear gall powder, mile swertia and dry extract respectively; sieving with a 120-mesh sieve, mixing uniformly and sterilizing; pilling with diluted ethanol, drying and preparing to 1,000g; and inspecting, performing split charging and warehousing. The formula of the bepiastine is scientific and reasonable, the requirements of mile swertia and bear gall powder raw materials are strict, a bepiastine product has stable quality and a perfect production process, and production conditions are consistent with Good Manufacturing Practice (GMP), i.e., a medicament production GMP standard. The bepiastine product has remarkable curative effects on the treatment of acute and chronic hepatitis, cholecystitis and gall-stone, resisting of arrhythmia, reduction in cholesterol in blood and triglyceride and prevention of hyperlipoidemia and renal hypertension. After long-term use, the bepiastine is free from untoward effects, and is safe and reliable.

The invention relates to a water nourishing and kidney clearing pill and a preparation method thereof. The water nourishing and kidney clearing pill is prepared from the following raw materials by weight: 0.1-6 parts of prepared rehmannia root, 0.1-4 parts of Chinese yam, 0.1-5 parts of cape jasmine, 0.5-4 parts of cornus officinalis, 0.1-4 parts of radix bupleuri, 0.1-4 parts of cortex moutan, 0.1-3 parts of spina date seed, 0.5-5 parts of rhizoma alismatis, 0.5-3 parts of radix paeoniae alba, 0.1-6 parts of Chinese angelica, and 0.5-5 parts of poria cocos. The water nourishing and kidney clearing pill provided by the invention has high effective component content, has obvious antihypertensive effect on renal hypertension rats and significant curative effect, also has low content of harmful ingredients, can effectively remove heavy metals, aflatoxin and other ingredients, and improves the medication safety.

The invention discloses a traditional Chinese medicine composition for treating renal hypertension. The traditional Chinese medicine composition for treating renal hypertension is prepared from the following medicinal raw materials in parts by weight: 3-20 parts of prepared aconite root, 10-60 parts of astragalus root, 7.5-30 parts of pachyma cocos, 10-60 parts of roripa Montana and 5-20 parts of rhizoma zedoariae. In addition, the invention further discloses a preparation method and application of the traditional Chinese medicine composition for treating renal hypertension. Experiments show that the traditional Chinese medicine composition disclosed by the invention has the functions of definitely reducing renal hypertension and protecting the kidneys, and can continuously improve the blood pressure condition of patients suffering from renal hypertension; the composition disclosed by the invention is conveniently taken with a small dosage and has reliable curative effect.

The invention discloses an application of anemoside B4 to preparation of medicines for reducing blood pressure. The anemoside B4 has treatment effects on high blood pressure, can reduce blood pressureof renal hypertension, can also reduce blood pressure of spontaneously hypertensive, has protection effects on high blood pressure and has the effects of improving cardiac functions.

The invention discloses a fortunella margarita extract as well as a preparation method and application thereof. The fortunella margarita extract is a pure natural substance extracted from fortunella margarita fruits. The fortunella margarita extract is obtained through ethanol reflux extraction, the main active ingredients and content in the fortunella margarita extract are determined by using GC-MS, and a hypertension animal model establishment test proves that the fortunella margarita extract and the active ingredients thereof can obviously reduce vasodilation pressure, regulate angiotensinII and other vasodilation factors, and besides, relieve target organ damage caused by hypertension. Cell tests prove that the HUVEC cell viability induced by the angiotensin II can be regulated. Therefore, the fortunella margarita extract has a good prevention and treatment effect on renal hypertension.

The invention discloses a compound preparation containing benidipine hydrochloride and benazepril hydrochloride, as well as application thereof, wherein preparation containing benidipine hydrochloride and benazepril hydrochloride serve as effective components of the medicament. According to the compound preparation, the defects of large dose and high side effect of single drug are overcome, and the compound preparation disclosed by the invention is obtained by compounding the benidipine hydrochloride and benazepril hydrochloride. Oral preparations with different forms can be prepared by the preparation, due to synergic and complementary effects of medicaments, the compound preparation has reinforced treatment effect, the medicament dose is reduced in clinical application, adverse reaction of a patient is lightened, and the compound preparation can be accepted easily. The compound preparation has remarkable treatment effect in mild and severe hypertension, and is suitable for hypertension patient with cardiovascular remodeling, and patients with renal hypertension, hypertension with renal damage or with diabetic renal damage. Furthermore, the compound preparation has low price, simple preparation and easy popularization and application.

The invention discloses a kumquat essential oil, a preparation method and application thereof. Kumquat essential oil is a kind of pure natural substance extracted from kumquat fruit. The present invention obtains kumquat essential oil through dry steam extraction, uses GC-MS to measure the main active components and content in the kumquat essential oil, and then establishes a hypertensive animal model test to prove that the kumquat essential oil and its active components can significantly reduce blood vessel Systolic blood pressure, regulating angiotensin II and other vasodilatory factors, while reducing target organ damage caused by high blood pressure; through cell experiments, it has been proved that it can regulate angiotensin II to induce HUVEC cell viability. Therefore, kumquat essential oil has a good preventive effect on renal hypertension.