Preparation method of medicine for treating hypertension

A technology for hypertension and drugs, applied in the field of drug preparation, can solve problems such as strong drug dependence, large side effects, and easy damage to organs, and achieve the effects of less drug dependence, lowering blood pressure, and drug safety.

Inactive Publication Date: 2013-05-22
HEILONGJIANG UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to solve the problem that the existing antihypertensive drugs can only relieve symptoms, and the drug dependence is strong, the side effects are large, and the organs are easily damaged by long-term use, and a preparation method of the drug for treating hypertension is provided.

Method used

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  • Preparation method of medicine for treating hypertension
  • Preparation method of medicine for treating hypertension
  • Preparation method of medicine for treating hypertension

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Experimental program
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specific Embodiment approach 1

[0011] Specific embodiment one: the preparation method of the medicine for the treatment of hypertension in this embodiment is carried out according to the following steps:

[0012] 1. Weigh Tongtiancao, add 10 times the mass of Tongtiancao and soak in absolute ethanol with a mass concentration of 80% for 1.5-2 hours, then heat to reflux for 1.5-2 hours, after gauze filtration, the filtrate is set aside, and the filter residue is refluxed twice, Combine the two filtrates into a rotary evaporator, and recover ethanol under reduced pressure at 40-50°C;

[0013] 2. After step 1 is evaporated, the remaining thick paste in the rotary bottle is placed in an evaporating dish, evaporated to dryness in a water bath at 90°C, put into a drying oven, and dried at 60°C to obtain a dry paste of the alcohol extract, which is then powdered to obtain an active The granular powder of the components, that is, the preparation of the medicine for treating hypertension is completed.

[0014] The m...

specific Embodiment approach 2

[0015] Specific embodiment 2: The difference between this embodiment and specific embodiment 1 is: in step 1, take Tongtiancao, add 10 times the mass of Tongtiancao and soak in absolute ethanol with a mass concentration of 80% for 1.6h, and then heat to reflux 1.6h. Other steps and parameters are the same as those in Embodiment 1.

specific Embodiment approach 3

[0016] Embodiment 3: The difference between this embodiment and Embodiment 1 is that in Step 1, ethanol is recovered under reduced pressure at 45°C. Other steps and parameters are the same as those in Embodiment 1.

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Abstract

The invention discloses a preparation method of a medicine for treating hypertension and relates to the preparation method of the medicine for treating hypertension. The preparation method comprises the following steps of: firstly, adding ethanol to soak waternut culm, heating up the mixed solution until the mixed solution is reflowed, filtering the mixed solution, collecting the filtrate for future use, carrying out reflux extraction on the filter residue twice, combining the filtrates, filling the combined filtrate to a rotary evaporator, and recycling the ethanol under reduced pressure; and secondly, putting residual thick paste in a rotary bottle to an evaporating dish, drying the thick paste in a water bath, putting the dried thick paste to a drying box, obtaining the ethanol-extraction substance dry paste by drying, pulverizing the dry paste to obtain granular powder with active ingredients, namely completing the preparation process. According to the preparation method disclosed by the invention, the hypertension ethanol extract has a good effect for treating renal hypertension and better safety, so that a new scheme is provided for developing the traditional Chinese medicine neurogenic hypertension drug, and a novel strategy is provided for treating the hypertension. The prepared medicine for treating the hypertension can be used for effectively reducing blood pressure and reducing systolic pressure more remarkably relative to diastolic pressure, is free of side effects, not capable of damaging visceral organs after being taken for a long time, small in drug dependence and safer in drug use.

Description

technical field [0001] The invention relates to a preparation method of a medicine for treating hypertension. Background technique [0002] Hypertension is a clinical syndrome characterized by elevated systemic arterial pressure, which can cause damage to target organs such as the heart, kidney, brain, and blood vessels, accompanied by systemic metabolic changes, and is the main cause of cardiovascular and cerebrovascular diseases. Risk factors are a major public health problem worldwide. According to the 2004 survey on nutrition and health status of Chinese residents, the prevalence rate of hypertension among residents aged 18 and over in my country is 18.8%, and it is estimated that the number of patients nationwide exceeds 160 million. At present, the morbidity and mortality of hypertension are in the forefront in our country. In recent years, with the in-depth research on the pathogenesis of hypertension, it has been found that vascular endothelial cells are closely re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/89A61P9/12
Inventor 周忠光贾博宇焦月华刘永武姜波严妍于敏朴成玉房城安柏松赵良友吴娟
Owner HEILONGJIANG UNIV OF CHINESE MEDICINE
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