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Preparation method and application of effective part of dracocephalum heterophyllum benth

A technology for the effective parts of Qinglan Heterophylla, which is applied to the preparation of the effective parts of Qinglan Heterophyllum. The effective parts of Qinglan Heterophyllum are used in the field of drugs for preventing and treating hypertension, and can solve the problems that the incidence of heart failure and mortality are not effectively controlled.

Inactive Publication Date: 2013-05-01
XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the incidence and mortality of hypertensive myocardial hypertrophy and its progressive heart failure have not been effectively controlled

Method used

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  • Preparation method and application of effective part of dracocephalum heterophyllum benth
  • Preparation method and application of effective part of dracocephalum heterophyllum benth
  • Preparation method and application of effective part of dracocephalum heterophyllum benth

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Example 1: Preparation of the effective part of Qinglan heterophylla:

[0016] Grind 12 kg of dry above ground parts of Qinglan phoenix into 2 cm, add 5 times the volume of 50% ethanol to heat and reflux for extraction at a temperature of 75°C for 1 hour, cool to room temperature, and concentrate in vacuo to obtain the ethanol extract of Qinglan phoenix ;

[0017] The obtained ethanol extract is separated by AB-8 macroporous resin, first eluted with 3 times the column volume of water, and then eluted with 50% ethanol to obtain the ethanol fraction, and then concentrated in a vacuum to obtain Qinglan isophyllum Total flavonoids fraction 205g.

Embodiment 2

[0018] Embodiment 2: Preparation of the effective part of Qinglan heterophylla:

[0019] Grind 12 kg of dry aerial parts of Qinglan phoenix into 2 cm, add 10 times the volume of 70% ethanol to heat and reflux for extraction at a temperature of 90°C for 2 hours, cool to room temperature, and concentrate in vacuo to obtain the alcoholic extract of Qinglan phoenix ;

[0020] The obtained ethanol extract is separated by HPD-450 macroporous resin, first eluted with 3 times the column volume of water, and then eluted with 70% ethanol to obtain the ethanol fraction, and then concentrated in vacuum to obtain the green orchid The total flavonoid fraction is 187g.

Embodiment 3

[0021] Embodiment 3: Preparation of the effective part of Qinglan heterophylla:

[0022] Grind 12 kg of dry aboveground parts of Qinglan phoenix into 2 cm, add 15 times the volume of 60% ethanol to heat and reflux for extraction at a temperature of 80°C for 3 hours, cool to room temperature, and concentrate in vacuo to obtain the alcoholic extract of Qinglan phoenix ;

[0023] The obtained ethanol extract is separated by polyamide resin, first eluted with 3 times the column volume of water, and then eluted with 60% ethanol to obtain the ethanol fraction, and then vacuum concentrated to obtain the total flavonoids Part 190g.

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Abstract

The invention relates to a preparation method and an application of an effective part of dracocephalum heterophyllum benth. The method comprises the steps that an aboveground part of the dracocephalum heterophyllum benth is smashed, extracted by an organic solvent, namely alcohol, and subjected to macroporous resin separation and purification to form the effective part of the dracocephalum heterophyllum benth. A preliminary activity screening test proves that the effective part of the dracocephalum heterophyllum benth obtained by the method has functions of lowering renal hypertension and rat blood pressure, and enhancing diastole and systole, and can also effectively prevent and treat hypertension complications including myocardial hypertrophy, renal injuries and vascular endothelial injuries. The method is simple in technology, low in production cost, and easy to control, and does not require high temperature or high pressure equipment, and the quality of the effective component is stable.

Description

technical field [0001] The invention relates to a preparation method and application of the effective part of Cymbidium heterophylla, in particular to the application of the effective fraction of Cymbidium heterophylla in the medicine for preventing and treating hypertension, and belongs to the technical field of ethnic medicine. Background technique [0002] Dracocephalum heterophyllum Benth. is a traditional Uyghur and Tibetan folk medicine. The whole herb is used as medicine. It tastes pungent, bitter, and cold in nature. It has the effects of calming the liver and clearing away heat. It can treat high blood pressure, lung-heat cough, bronchitis and other diseases . Compositional analysis found that Qinglan is rich in flavonoids, terpenoids and other substances, and the content of inorganic elements (Ca, Fe, Mg) is relatively high. [0003] Hypertension is a common disease and the most risk factor for coronary heart disease, stroke, and renal failure. At present, the dr...

Claims

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Application Information

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IPC IPC(8): A61K36/53A61P9/12
Inventor 阿吉艾克拜尔·艾萨萨迪克·诺莫诺夫何雯帕尔哈提·克力木赵江瑜邬丽娅·伊明马晓玲司丽君闫冬魏媛媛程路峰阿迪力·阿不都热合曼
Owner XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI
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