5 results about "Vascular Calcifications" patented technology

The present invention relates to a composition for improving cardiovascular calcification using a mulberry tree extract and a method for preparing the same. The composition is prepared by collecting the fruit (mulberry), leaves (mulberry leaves), branches (mulberry branches), and root bark (mulberry bark) of the mulberry tree, extracting the fruit and freeze-drying it to produce a mulberry extract, hot-air drying the leaves, branches, and root bark, adding 20-70% ethanol corresponding to 5-50% by weight of each, extracting at 50-90°C for 2-10 hours, filtering and concentrating the extract, and freeze-drying the extract to obtain a mulberry tree extract, and dissolving each extract in distilled water at a concentration of 10-50 mg / ml to provide a composition for improving cardiovascular calcification using a mulberry tree extract and a method for preparing the same, thereby enabling relatively safe and effective improvement of cardiovascular calcification, including vascular calcification.

This invention relates to the pharmaceutical applications of HSPB6 in the prevention and treatment of vascular calcification, belonging to the field of biomedical technology. This invention is the first to demonstrate a significant negative correlation between HSPB6 expression levels and the progression of vascular calcification. HSPB6 overexpression can significantly inhibit osteogenic phenotype transformation of vascular smooth muscle cells, reduce in vitro and in vivo vascular calcium deposition, and delay the occurrence and development of vascular calcification. Based on this, this invention provides the application of HSPB6 expression level detection reagents in the preparation of auxiliary diagnostic products for vascular calcification, and the application of HSPB6-specific overexpression reagents in the preparation of drugs for the prevention and / or treatment of vascular calcification, providing new targets and strategies for the early diagnosis and targeted prevention and treatment of vascular calcification.

This invention discloses the application of limonene in the preparation of drugs for alleviating or improving vascular calcification. Intervention with limonene in CKD mouse models and primary vascular smooth muscle cells (VSMCs) significantly inhibited aortic calcification in CKD mice, significantly reduced high-phosphorus-induced osteogenic differentiation and calcium deposition in VSMCs, inhibited reactive oxygen species (ROS) production, reduced cellular iron accumulation, and alleviated ferroptosis. The findings of this application are highly likely to provide effective clinical drugs for the prevention and treatment of vascular calcification in CKD.

The utility model provides a kind of catheter assembly and medical equipment.Catheter assembly includes first tube body and shock wave generation component.First tube body is formed with first accommodating cavity.Shock wave generation component includes at least two discharge parts, at least two discharge parts are spaced apart and set to the distal end in first accommodating cavity along the length direction of first tube body, at least two adjacent discharge parts form discharge region, to produce shock wave in liquid medium in first accommodating cavity.Wherein, discharge region is parallel to the central axis of first tube body, and at least part discharge region and the central axis of first tube body are overlapped.Such ensure that catheter assembly can have smaller size in radial direction, effectively improve the practicability of catheter assembly.In the treatment of blood vessel calcification lesion using catheter assembly, catheter assembly can directly pass through relatively narrow lesion site, effectively simplify the treatment step, reduce the cost required for treatment, and improve the experience of patient use.

This application relates to the field of interventional medical device technology and provides a shockwave balloon catheter, including a balloon, an inner tube, an outer tube, and an electrode assembly. The distal end of the inner tube passes through the lumen of the balloon and is sealed to the distal end of the balloon; the outer tube is sleeved on the inner tube, and the proximal end of the balloon is sealed to the distal end of the outer tube. The electrode assembly is used to generate a shockwave by energizing the inner tube, and the electrode assembly is connected to the inner tube located in the lumen. In this embodiment, an insulating layer is provided on the outer surface of the electrode assembly, and a discharge zone is formed by removing parts of the insulating layer on the outer surface of the electrode assembly. This insulating layer insulates the outer surface of the electrode assembly, allowing the charge on the electrode assembly to be concentrated in the discharge zone, thereby stably generating an electric arc and forming a stable shockwave that acts on the calcified vascular lesion, improving the surgical treatment effect.