2 results about "CxC chemokine" patented technology

This invention relates to the field of biological detection, and more particularly to a monoclonal antibody combination for detecting human IL-8 protein and its application. The combination comprises monoclonal antibodies 2G3 and 3H8. The heavy and light chain variable regions of monoclonal antibody 2G3 include the complementarity-determining regions shown in SEQ ID NO. 1-6; the heavy and light chain variable regions of monoclonal antibody 3H8 include the CDRs shown in SEQ ID NO. 7-12. The antibody combination of this invention exhibits high specificity and effectively avoids cross-reactivity with other CXC chemokine family members, thereby significantly reducing non-specific background interference and the risk of false positives during detection. This invention provides a high-performance, quality-controllable key tool for biological detection for non-diagnostic purposes, research on inflammatory mechanisms, and the development of related scientific reagents.

The invention relates to a peptide comprising an amino acid sequence X6X7X8X9X10X11X12 according to SEQ ID NO: 1, or its pharmacologically acceptable salts, derivatives and / or conjugates, wherein X6 is G or A, X7 is R or A, X8 is R or A, X9 is T or A, X10 is R or A, X11 is L or A, X12 is C or A, with the proviso that one of the amino acids at position X6, X7, X8, X9, X10, X11 or X12 may be alanine, wherein the peptide has a total length in the range of 7 to 30 amino acids, and wherein a peptide consisting of the amino acid sequence KRRPAKAWSGRRTRLCC according to SEQ ID NO: 2 is excluded. The invention further relates to a medicament comprising a peptide according to SEQ ID NO: 1 and to a use for the manufacture of a medicament.