High-affinity antagonists of ELR-CXC chemokines
a chemokine and high-affinity technology, applied in the field of cxc chemokine receptor antagonists, can solve the problem that no cxc chemokine antagonists are known in the prior art that are effectiv
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[0069] (The following abbreviations are used throughout this disclosure: ARDS, acute respiratory distress syndrome; BALF, bronchoalveolar lavage fluid(s); BHR, Bolton-Hunter Reagent; CXCR1, CXCR2, CXCL8 receptors A, B, respectively; ELR, glutamic acid-lysine-arginine motif; CXCL1, growth-related oncogenealpha; CXCL4, platelet factor-4; CXCL5, epithelial-derived neutrophil activator-78; CXCL6, granulocyte chemotactic protein-2; CXCL8, interleukin-8; fMLP, formyl methionyl-leucylproline bacterial tripeptide; IPTG, isopropyl-thio-D-galactopyranoside; MIP-2, macrophage inflammatory protein-2; PMSF, phenylmethylsulfonyl fluoride; TMB, tetramethylbenzidine.)
[0070] As used herein, ‘an agonist’ refers to an agent that causes a cell to become activated.
[0071] As used herein, ‘an antagonist’ refers to an agent that prevents the cell from being activated in the presence or absence of the agonist.
[0072] As used herein, “purified” does not require absolute purity but is instead intended as a ...
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