Pan-ELR<+> CXC chemokine antibodies

An antibody, chemotactic protein technology, applied in the direction of antibodies, anti-cytokine/lymphokine/interferon immunoglobulin, anti-tumor drugs, etc. 2 Combination and other issues
CN109134652AActive Publication Date: 2019-01-04ELI LILLY & CO
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
ELI LILLY & CO
Publication Date
2019-01-04

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Abstract

Antibodies are provided that specifically bind seven human ELR<+> CXC chemokines. The antibodies of the invention are useful for treating various inflammatory / autoimmune diseases, such as inflammatorybowel disease (IBD), plaque psoriasis, and palmoplantar pustulosis; and cancer, such as renal cancer or ovarian cancer.
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Description

[0001] This application is a Chinese patent application 201480013248.X "Pan-ELR" with the filing date of March 5, 2014 + Divisional application of "CXC Chemokine Antibody". Technical field

[0002] The present invention relates to antibodies against ELR+CXC chemokines and their use in the treatment of diseases mediated by ELR+CXC chemokines. Background technique

[0003] ELR+ CXC chemokines (so called because members of the chemokine family have ELR amino acid motifs next to their CXC motifs) play an important role in various pathogenesis, including neutrophils to inflammation and blood vessels Generate site migration. Neutrophils contribute to the onset of several acute and chronic inflammatory / autoimmune diseases, such as inflammatory bowel disease (IBD), psoriasis, and palmoplantar pustulosis. ELR+ CXC chemokines also play a key role in tumor formation and tumor metastasis. These chemokines are highly expressed in tumors. In the tumor environment, ELR+CXC chemokines are inv...

Claims

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