Application of icariin in preparation of medicine for preventing and treating chronic kidney disease mineral substance and bone metabolism disorder

By using icariin to prepare various drug formulations, the treatment challenges of mineral and bone metabolism disorders in chronic kidney disease have been solved. It significantly improves renal fibrosis, inhibits hyperparathyroidism, corrects calcium and phosphorus metabolism, regulates bone metabolism, prevents and treats mineral and bone metabolism disorders in chronic kidney disease, and improves medication safety and compliance.

CN121154664APending Publication Date: 2025-12-19TIANJIN INST OF MEDICAL SCI (TIANJIN MEDICINE & HEALTH RES CENT)
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Patent Information

Application Number
CN202511672791.7
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-11-14
Publication Date
2025-12-19

AI Technical Summary

Technical Problem

Current technologies lack clearly effective drugs for the prevention and treatment of mineral and bone metabolism disorders in chronic kidney disease, and traditional Chinese medicine treatments are characterized by complex components and unclear mechanisms of action.

Method used

Icariin and its derivatives or pharmaceutically acceptable salts are used to prepare oral or injectable formulations for inhibiting hyperparathyroidism and vascular calcification, and regulating the expression of bone metabolism-related molecules. These formulations are prepared in the form of microemulsions, tablets, pills, capsules, granules, or injections.

Benefits of technology

It significantly improves renal fibrosis, inhibits hyperparathyroidism, corrects calcium and phosphorus metabolism, regulates bone metabolism, inhibits the transdifferentiation of vascular smooth muscle cells into osteocytes, prevents and treats mineral and bone metabolism disorders in chronic kidney disease, and improves medication safety and compliance.

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Abstract

The invention discloses application of icariin in preparation of drugs for preventing and treating chronic kidney disease mineral substances and bone metabolism disorders. Relates to the technical field of medicine. The invention provides an application of icariin as an active pharmaceutical ingredient in preparation of a CKD-MBD treatment drug. Pharmacological experiments show that icariin can improve renal fibrosis, inhibit hyperparathyroidism, correct calcium and phosphorus metabolism, regulate and control bone metabolism related molecular expression, inhibit transdifferentiation of vascular smooth muscle cells to bone cells, inhibit vascular calcification and correct bone metabolism disorder, so that CKD-MBD is effectively prevented and treated. When icariin is used for preventing or treating CKD-MBD, the icariin is clear in component, exact in curative effect and low in side effect, and has a wide medical application prospect.
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