Pharmaceutical composition using efonidipine as active ingredient, its preparation method and use
A technology of efodipine hydrochloride, active ingredient, applied in the field of medicine
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Embodiment 1
[0020] Example 1 Efdipine Hydrochloride Tablets
[0021] prescription:
[0022] Component Dosage
[0023] Efodipine Hydrochloride 10g
[0024] Microcrystalline Cellulose 50g
[0025] 10g pregelatinized starch
[0026] Lactose 45g
[0027] CMS-Na 3g
[0029] 95% ethanol appropriate amount
[0030] A total of 1000 pieces were made
[0031] Preparation:
[0032] Pass efodipine hydrochloride, microcrystalline cellulose, pregelatinized starch, and lactose through 80-mesh sieve respectively, after mixing evenly, add 95% ethanol in an appropriate amount to make soft material, granulate with 20-mesh sieve, dry, granulate with 18-mesh sieve, Add CMS-Na and magnesium stearate, mix evenly, and press a suitable die to form a tablet.
Embodiment 2
[0033] Embodiment 2: Efodipine Hydrochloride Capsules
[0034] prescription:
[0035] Component Dosage
[0036] Efodipine Hydrochloride 20g
[0037] Microcrystalline Cellulose 80g
[0038] 2% PVP-k 30 ethanol solution appropriate amount
[0039] CMS-Na 2.0g
[0041] Preparation:
[0042] Pass efodipine hydrochloride and microcrystalline cellulose through 80-mesh sieve respectively, mix well, add 2% PVP-k 30 ethanol solution to make soft material, granulate with 24-mesh sieve, dry, granulate with 24-mesh sieve, add prescription Amount of CMS-Na, talcum powder, mix evenly and pack into suitable capsule shells.
Embodiment 3
[0043] Embodiment 3: Efodipine Hydrochloride Dispersible Tablet
[0044] prescription:
[0045] Component Dosage
[0046] Efodipine Hydrochloride 10g
[0047] Microcrystalline Cellulose 160g
[0048] Mannitol 100g
[0049] CMS-Na 12g
[0050] L-HPC 3g
[0051] Grape essence 12g
[0053] 75% ethanol appropriate amount
[0054] A total of 1000 pieces were made
[0055] Preparation:
[0056] Pass efodipine hydrochloride, microcrystalline cellulose, and mannitol through a 80-mesh sieve respectively, mix well, add an appropriate amount of 75% ethanol solution to make a soft material, granulate with a 24-mesh sieve, dry, granulate with a 20-mesh sieve, and disintegrate Agent CMS-Na, L-HPC, grape essence, talcum powder, mix evenly and compress into tablets to obtain.
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