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Pharmaceutical composition using efonidipine as active ingredient, its preparation method and use

A technology of efodipine hydrochloride, active ingredient, applied in the field of medicine

Inactive Publication Date: 2006-09-06
BEIJING RUNDEKANG MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no related patent in China

Method used

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  • Pharmaceutical composition using efonidipine as active ingredient, its preparation method and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1 Efdipine Hydrochloride Tablets

[0021] prescription:

[0022] Component Dosage

[0023] Efodipine Hydrochloride 10g

[0024] Microcrystalline Cellulose 50g

[0025] 10g pregelatinized starch

[0026] Lactose 45g

[0027] CMS-Na 3g

[0028] Magnesium Stearate 2g

[0029] 95% ethanol appropriate amount

[0030] A total of 1000 pieces were made

[0031] Preparation:

[0032] Pass efodipine hydrochloride, microcrystalline cellulose, pregelatinized starch, and lactose through 80-mesh sieve respectively, after mixing evenly, add 95% ethanol in an appropriate amount to make soft material, granulate with 20-mesh sieve, dry, granulate with 18-mesh sieve, Add CMS-Na and magnesium stearate, mix evenly, and press a suitable die to form a tablet.

Embodiment 2

[0033] Embodiment 2: Efodipine Hydrochloride Capsules

[0034] prescription:

[0035] Component Dosage

[0036] Efodipine Hydrochloride 20g

[0037] Microcrystalline Cellulose 80g

[0038] 2% PVP-k 30 ethanol solution appropriate amount

[0039] CMS-Na 2.0g

[0040] Talc powder 1.0g

[0041] Preparation:

[0042] Pass efodipine hydrochloride and microcrystalline cellulose through 80-mesh sieve respectively, mix well, add 2% PVP-k 30 ethanol solution to make soft material, granulate with 24-mesh sieve, dry, granulate with 24-mesh sieve, add prescription Amount of CMS-Na, talcum powder, mix evenly and pack into suitable capsule shells.

Embodiment 3

[0043] Embodiment 3: Efodipine Hydrochloride Dispersible Tablet

[0044] prescription:

[0045] Component Dosage

[0046] Efodipine Hydrochloride 10g

[0047] Microcrystalline Cellulose 160g

[0048] Mannitol 100g

[0049] CMS-Na 12g

[0050] L-HPC 3g

[0051] Grape essence 12g

[0052] Talc powder 3g

[0053] 75% ethanol appropriate amount

[0054] A total of 1000 pieces were made

[0055] Preparation:

[0056] Pass efodipine hydrochloride, microcrystalline cellulose, and mannitol through a 80-mesh sieve respectively, mix well, add an appropriate amount of 75% ethanol solution to make a soft material, granulate with a 24-mesh sieve, dry, granulate with a 20-mesh sieve, and disintegrate Agent CMS-Na, L-HPC, grape essence, talcum powder, mix evenly and compress into tablets to obtain.

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Abstract

The invention relates to a medicinal composition using Efonidipine as the active constituent, the process for preparation and use thereof, which also contains pharmaceutically acceptable auxiliary materials, and can be used for the treatment of primary hypertension, severe hypertension and renal hypertension. The composition can be prepared into tablets, capsules, dispersible tablets, soft capsules, chewable tablets, buccal tablets, buccal tablets, dried suspending agents, and dripping pills.

Description

technical field [0001] The invention relates to a pharmaceutical composition with efodipine hydrochloride as an active ingredient, a preparation method and application thereof, and belongs to the technical field of medicine. Background technique [0002] With the improvement of people's living standards and changes in dietary structure and lifestyle, the incidence of hypertension has gradually increased in recent years. Hypertension can cause damage to the heart, brain, kidney and other organs of the patient, and is closely related to sugar and lipid metabolism disorders and diabetes, which can significantly reduce the quality of life of the patient, and even endanger life in severe cases. Therefore, the research on the pathogenesis and therapeutic drugs of hypertension has attracted more and more attention from scholars at home and abroad. [0003] The prevalence of hypertension in our country has risen significantly. Based on the prevalence of the high-incidence age group...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/675A61K9/20A61K9/48A61P9/12
Inventor 李胜飞
Owner BEIJING RUNDEKANG MEDICAL TECH CO LTD
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