Application of Chinese yarn glycoprotein in preparation of medicament for treating nephritis and renal hypertension

A technology of yam sugar and protein, which is applied in the directions of drug combination, peptide/protein composition, pharmaceutical formula, etc., to achieve the effects of sufficient drug source, simple and easy extraction and preparation method, and good treatment effect.

Active Publication Date: 2013-02-13
新乡博凯生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Further studies of the present invention on this basis show that: yam glycoprotein can effectively treat glomerulonephritis and renal hypertension at the same time, without toxic and side effects, and is very safe compared to existing clinically used drugs, but so far , no related reports

Method used

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  • Application of Chinese yarn glycoprotein in preparation of medicament for treating nephritis and renal hypertension
  • Application of Chinese yarn glycoprotein in preparation of medicament for treating nephritis and renal hypertension
  • Application of Chinese yarn glycoprotein in preparation of medicament for treating nephritis and renal hypertension

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Embodiment 1: the preparation of yam glycoprotein

[0014] Take 1000g of yam raw medicine and crush it into fine powder, add 2 times the amount of water to heat, the temperature is 50°C, extract twice, each time for 2 hours, filter and combine the two extracts, concentrate the extract to 50%, and the concentration to 95 Add % ethanol to the concentrated solution to make the alcohol content reach 60%. After the white precipitate appears, let it stand for 3-6 hours, separate the precipitate from the supernatant, and continue to add 95% ethanol to the supernatant to make it Its alcohol content reaches 90%, and a brown precipitate appears. After standing for 3-6 hours, the supernatant is removed to collect the precipitate, dried, and brown or dark brown viscose solid thick yam glycoprotein can be obtained.

Embodiment 2

[0015] Embodiment 2: the preparation of yam glycoprotein

[0016] Take 1000g of the original Chinese yam and crush it into a coarse powder, add 3 times the amount of water to heat, the temperature is 70°C, extract twice, each time for 3 hours, after filtering, combine the two extracts, concentrate 50%, add ethanol with a concentration of 95% Make the alcohol content reach 70% in the concentrated solution, white precipitate appears, let it stand for 3-6 hours, separate the precipitate from the supernatant, and continue to add ethanol with a concentration of 95% to the supernatant to make the alcohol content reach 90% %, a brown viscose precipitate appears, the supernatant is removed, the precipitate is collected, and vacuum-dried to obtain the purer yam glycoprotein in brown or dark brown solid.

Embodiment 3

[0017] Embodiment 3: the preparation of yam glycoprotein

[0018] Take 1000g of yam raw medicine and crush it into large particles, add 5 times the amount of water to heat, the temperature is 100°C, extract 3 times, each time for 2 hours, after filtering, combine the two extracts, concentrate to 50%, and dilute the concentration to 95% ethanol Add it to the concentrated solution to make the alcohol content reach 75%. After the white precipitate appears, extract the supernatant. Continue to add ethanol with a concentration of 98% to the supernatant to make the alcohol content reach 95%. Yellow-brown viscose appears The supernatant was removed, and the precipitate was collected for vacuum freeze-drying to obtain the purer yam glycoprotein in the form of brown crystals.

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PUM

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Abstract

The invention relates to an application of Chinese yarn glycoprotein in preparation of a medicament for treating nephritis and renal hypertension. Selection and verification are carried out by an animal test to prove that the Chinese yarn glycoprotein has the effects of treating glomerulonephritis and renal hypertension and has high safety. The Chinese yarn glycoprotein is derived from natural plants, medicine sources are sufficient, extraction and preparation method is simple and practicable, and the prepared medicament can be prepared into multiple dosage forms such as capsules, tablets, granules and oral liquid.

Description

technical field [0001] The invention relates to the use of yam glycoprotein in the preparation of medicines for treating nephritis and renal hypertension. Background technique [0002] Glomerulonephritis and renal hypertension are relatively common kidney diseases. It is generally believed that glomerulonephritis is a kidney disease caused by immune pathological damage. This disease is more common in adults, and the course of the disease is longer, often more than one year, with proteinuria, microscopic hematuria, hypertension, edema, renal function damage, etc. Currently clinically used drugs are mainly; glucocorticoids, cytotoxic immunosuppressants, non-steroidal anti-inflammatory drugs. The treatment of renal hypertension is mainly angiotensin-converting enzyme inhibitors represented by captopril, combined with other types of antihypertensive drugs. There is no doubt that there are few toxic and side effects, and the effect is significant and extensive A new drug that c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/16A61P13/12A61P9/12
CPCA61K38/168A61P9/12A61P13/12A61P39/06
Inventor 多力坤·马木特
Owner 新乡博凯生物技术有限公司
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