174results about How to "Increase heart rate" patented technology

Apparatus is provided for treating a condition of a subject, including an electrode device, adapted to be coupled to an autonomic nerve of the subject, and a control unit. The control unit is adapted to drive the electrode device to apply to the nerve a stimulating current, which is capable of inducing action potentials in a therapeutic direction in a first set and a second set of nerve fibers of the nerve, and to drive the electrode device to apply to the nerve an inhibiting current, which is capable of inhibiting the induced action potentials traveling in the therapeutic direction in the second set of nerve fibers, the nerve fibers in the second set having generally larger diameters than the nerve fibers in the first set. Other embodiments are also described.

Apparatus (20) for use with a subject (30) is provided, including a memory, storing a set of computer instructions, the memory adapted to have stored therein an initial form of a multi-phase biorhythmic activity pattern and an indication of a desired form of the multi-phase biorhythmic activity pattern, wherein a ratio of durations of two phases in the desired form is different from a ratio of durations of the respective phases in the initial form, and wherein at least one phase of the multi-phase biorhythmic activity pattern corresponds to a respective phase of a multi-phase biorhythmic activity of the subject (30). The apparatus (20) further includes a stimulus unit (38), adapted to execute the stored instructions and to generate responsive thereto a time-varying stimulus that: (a) is substantially not responsive to ongoing measurement of the multi-phase biorhythmic activity during generation of the time-varying stimulus, and (b) has a multi-phase pattern that is characterized by a series of transitional forms intermediate the initial form and the desired form that guide the subject (30) to modify the biorhythmic activity.

Apparatus is provided that includes an electrode device, adapted to be coupled to a vagus nerve of a subject, and a control unit, adapted to drive the electrode device to apply to the vagus nerve a current that reduces heart rate variability of the subject. Also provided is a method comprising applying to a vagus nerve of a subject a current that reduces heart rate variability of the subject.

A multi-axis adjustable exercise machine which is pivotable about both a pitch axis and a roll axis with respect to a base for allowing an exerciser to perform a wide range of exercises on a pitched or rolled exercise machine. The multi-axis adjustable exercise machine generally includes an exercise machine which is adjustable with respect to a base. The exercise machine may be pivoted about a roll axis to adjust the roll angle of the exercise machine or may be pivoted about a pitch axis to adjust the pitch angle of the exercise machine. One or more actuators may be connected between the base and the exercise machine to effectuate the pivoting of the exercise machine about either or both axes with respect to the base.

The present invention is directed to methods and systems of data interpretation and inference making that are possible when a multitude of physiological or performance signals are captured continuously (or pseudo-continuously), synchronously, and simultaneously. In some embodiments, physiological or performance context is added to any individual data stream when combined with others.

The present invention relates to the secure delivery of an extra-systolic stimulation (ESS) therapy to treat cardiac dysfunction that employs atrial and/or ventricular extra-systoles via pacing-like stimulation of the heart. These extra-systoles must be timed correctly to achieve beneficial effects on myocardial mechanics (benefit) while maintaining an extremely low level of risk of arrhythmia induction and excellent ICD-like arrhythmia sensing and detection (security). Further experience with ESS has led to improved implementation methods that depend on better blanking, ESS stimulation timing (of an “extra-systolic interval” or ESI), and ESS therapy delivery options and guidance. These methods may be employed individually or in combinations in an external or implantable ESS therapy delivery device.

Methods and modules for using physiological (biometric) variables to advance the state of the artificial pancreas. The method and system includes one or more modules for recursive model identification, hypoglycemia early alert and alarm, adaptive control, hyperglycemia early alert and alarm, plasma insulin concentration estimation, assessment of physical activity (e.g., presence, type, duration, expected effects on insulin sensitivity and GC), detection of acute stress and assessment of its impact on insulin sensitivity, detection of sleep and its stages and assessment of sleep stages on GC, sensor fault detection and diagnosis, software and controller performance evaluation and adjustment and/or pump fault detection and diagnosis.

A method and system for providing a sound source suitable for an exercise state of a user by recognizing the exercise state of the user by measuring heart rate and exercise speed of the user. The method includes: determining a standard heart rate; measuring a heart rate of a user; measuring an exercise speed of the user; comparing the measured heart rate and the standard heart rate; when a difference between the both heart rates is more than a predetermined value, generating compensated exercise speed information based on the difference and the measured exercise speed; and replaying a sound source according to the compensated exercise speed information. According to the exercise state management method, heart rate suitable for the type, intensity, or time of exercise selected by the user and a sound source suitable for exercise speed are provided, thereby improving satisfaction and effectiveness of the exercise.

The present invention relates to methods and compositions for the treatment of pain, in a preferred embodiment relating to the oral transmucosal administration of S-Ketamine, its salts or derivatives.

A method of assessing the cardiac arrhythmia risk in a subject to provide a measure of cardiac or cardiovascular health in that subject is described herein. In one embodiment, the method comprises the steps of: (a) collecting at least one QT and RR interval data set from the subject; (b) separating fluctuations from slow trends in said at least one QT and RR interval data set; (c) comparing said QT and RR fluctuations to one another and (d) generating from the comparison of step (c) partial measures of risk of cardiac arrhythmia in said subject. A greater difference between QT and RR fluctuations indicates greater risk of cardiac arrhythmia in said subject. The data sets are collected in such a manner that they reflect almost exclusively the conduction in the heart muscle and minimize the effect on the data sets of rapid transients due to autonomic nervous system and hormonal control.

The present invention relates to a method for energizing a human being and to administering an energizing (personal care) composition to human beings wherein said composition contains one or more fragrance materials of group (a) of the present invention.

Methods and systems are provided for determining an increased likelihood of the occurrence of a cardiac arrhythmia, myocardial ischemia, congestive heart failure and other diseased conditions of the heart associated with elevated sympathetic neural discharges in a patient. The methods and systems comprise monitoring the sympathetic neural discharges of a patient from the stellate ganglia, the thoracic ganglia, or both, and detecting increases in the sympathetic neural discharges. The methods and systems may further comprise delivering therapy to the patient in response to a detected increase in the sympathetic neural discharge, such as delivering one or more pharmacological agents; stimulating myocardial hyperinnervation in the sinus node and right ventricle of the heart of the patient; and applying cardiac pacing, cardioversion or defibrillation shocks. Pharmacologic agents which may be used in connection with the delivery of include those which are known to exert anti-arrhythmic effect and anti-convulsant agents, such as phenytoin, carbamazepine, valproate, and phenobarbitone. Other pharmacologic agents may be used to treat impending myocardial ischemia and other diseased conditions of the heart associated with elevated sympathetic neural discharges.

This disclosure is directed to pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives. Pharmaceutical compositions comprising the compounds are also provided, as are methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder. The compounds may bind to and antagonize receptor α_2B, α_1B or α_2A. The compounds may find use in therapy, e.g., to (i) reduce blood pressure and/or (ii) promote renal blood flow and/or (iii) decrease or inhibit sodium reabsorption, or to regulate blood glucose level, increase insulin secretion and treat diseases or conditions that are, or are expected to be, responsive to an increase in insulin production. The compounds may also be used to treat diseases or conditions that are expected to be responsive to a decrease in blood pressure. Use of the compounds to treat cardiovascular, renal disorders or type 2 diabetes is particularly described.

A unit dosage form, such as a capsule or the like for delivering drugs into the body in a circadian release fashion, is comprising of one or more populations of propranolol-containing particles (beads, pellets, granules, etc.). Each bead population exhibits a pre-designed rapid or sustained release profile with or without a predetermined lag time of 3 to 5 hours. Such a circadian rhythm release cardiovascular drug delivery system is designed to provide a plasma concentration-time profile, which varies according to physiological need during the day, i.e., mimicking the circadian rhythm and severity/manifestation of a cardiovascular disease, predicted based on pharmaco-kinetic and pharmaco-dynamic considerations and in vitro/in vivo correlations.

A method of assessing cardiac ischemia in a subject to provide a measure of cardiovascular health in that subject is described. In general, the method comprises the steps of: (a) collecting a first RR-interval data set from the subject during a stage of gradually increasing heart rate; (b) collecting a second RR-interval data set from the subject during a stage of gradually decreasing heart rate (e.g., after an abrupt stop in exercise; during a stage of gradually decreasing exercise load; etc.); (c) separating fluctuations from a slow trend in the first RR-interval data set; (d) separating fluctuations from a slow trend in the second RR-interval data set; (e) comparing the fluctuations of the first RR-interval data set to the fluctuations of the second RR-interval data set to determine a difference between the fluctuation data sets; and (f) generating from the comparison of step (e) a measure of cardiac ischemia during stimulation in the subject, wherein a greater difference between the first and second data sets indicates greater cardiac ischemia and lesser cardiac or cardiovascular health in the subject.

Aminocyclohexyl ether compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses uses for the compounds and compositions, including the treatment of arrhythmia.

Aminocyclohexyl ether compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses uses for the compounds and compositions, including the treatment of arrhythmia.

A system and method are disclosed to acquire high temporal resolution free-breathing cardiac MR images. The technique includes monitoring heart rate of a patient just prior to image acquisition to acquire a time period of an R—R interval, and using this time period from the heart rate monitoring to prospectively estimate future R—R intervals. The acquisition of MR data can then commence at any point in an R—R interval and extend for the time period recorded. The data acquisition can be segmented and acquired in successive R—R intervals, then combined to create high temporal resolution images.

The invention discloses a processing technique of health thorn tea and processing equipment for health thorn tea, which relate to the technical field of processing of agricultural products. The health thorn tea is made of fresh thorn tea leaves. The processing technique includes cutting, primary fixation, primary spreading and cooling, secondary fixation, secondary spreading and cooling, primary rolling, tertiary spreading and cooling, primary baking, secondary rolling, fourth spreading and cooling, secondary baking, grading and packaging. The processed health thorn tea has the advantages of blood glucose lowering, blood lipid lowering, blood pressure lowering, immunity enhancement, heart rate slowing, coronary flow increasing, anticoagulation, antithrombosis, hypoxia tolerance, mononuclear macrophage functional promotion, radio resistance and the like, and is suitable for middle-aged and aged people and people with hyperlipidemia, hypertension and hyperglycemia. The processing technique and the processing equipment for the health thorn tea can also be used for processing common tea and other types of health tea.

Disclosed are methods and systems for treating epilepsy by stimulating a main trunk of a vagus nerve, or a left vagus nerve, when the patient has had no seizure or a seizure that is not characterized by cardiac changes such as an increase in heart rate, and stimulating a cardiac branch of a vagus nerve, or a right vagus nerve, when the patient has had a seizure characterized by cardiac changes such as a heart rate increase.

The invention discloses a coring drilling tool based on hydraulic clamping coring. The coring drilling tool comprises a force transferring power distribution mechanism, a guide limiting mechanism, a pressure storage mechanism, a lifting pressure injection mechanism, a hydraulic core clamping mechanism, a side spraying drill bit power distribution mechanism, an outer tube assembly and a sealing system, wherein the guide limiting mechanism is butted with the force transferring power distribution mechanism; the pressure storage mechanism is butted with the guide limiting mechanism; the lifting pressure injection mechanism is butted with the pressure storage mechanism; the hydraulic core clamping mechanism is butted with the lifting pressure injection mechanism; the side spraying drill bit power distribution mechanism is butted with the hydraulic core clamping mechanism; the hydraulic core clamping mechanism comprises a bottom bearing platform, a hydraulic membrane, a core inner tube, a clamp spring seat and a clamp spring. The coring drilling tool can reach 100 percent coring rate in soft, loose and broken complex stratums where coring is difficult, provides fully automatic three-dimensional stress to clamp, bind and control cores based on hydraulic pressure, meanwhile is matched with a conventional core clamping and cutting device, and has the characteristics of high reliability, high coring efficiency, high coring quality, high core recovery percentage, wide applicable stratum range and good automation property.

Magnetic recording media with high coercivity and low noise, suitable for high density longitudinal recording, are formed with a surface oxidized sub-seedlayer between a non-magnetic substrate and seedlayer. Embodiments include depositing a NiAl sub-seedlayer on a glass or glass-ceramic substrate, oxidizing the surface of the NiAl sub-seedlayer, and then sequentially depositing a NiAl seedlayer, Cr or Cr alloy underlayer, e.g., CrMo, an optional intermediate CoCrTa alloy layer, a magnetic layer, e.g., a Co-alloy magnetic layer, and a protective overcoat, e.g., a carbon-containing protective overcoat.