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Fumailing capsule for preventing and treating slow arrhythmia and preparation method of Fumailing capsule

A technique for arrhythmia and Fumai Ling, applied in the field of medicine, can solve the problems of atrial ectopic heart rhythm, thromboembolic complications and pacing syndrome, reduce hemodynamic effects, decrease systolic function, etc. Nodal function, prevention and treatment of sinus node function reduction, safe use effect

Inactive Publication Date: 2020-02-11
SECOND AFFILIATED HOSPITAL OF COLLEGE OF MEDICINEOF XIAN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in traditional right ventricular apical pacing, the shape and initial direction of ventricular contraction are opposite to the normal physiological excitation and contraction sequence, and the sequence of ventricular activation secondary to right ventricular apical pacing is abnormal, causing abnormal wall motion and decreased systolic function , reduces the hemodynamic effect, and even causes atrial ectopic heart rhythm, thromboembolism complications and pacing syndrome, so in recent years, physiological pacing is advocated, which requires the pacemaker to operate under different physiological conditions. Under this condition, try to simulate the function of the normal sinoatrial node and the conduction system to meet the needs of the body and produce hemodynamic effects close to the normal physiological state. However, due to the high cost and the requirement of a certain technical level and conditions, the clinical application is limited. Restricted, it is difficult to popularize in large quantities

Method used

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  • Fumailing capsule for preventing and treating slow arrhythmia and preparation method of Fumailing capsule
  • Fumailing capsule for preventing and treating slow arrhythmia and preparation method of Fumailing capsule
  • Fumailing capsule for preventing and treating slow arrhythmia and preparation method of Fumailing capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The Fumailing Capsules for preventing and treating bradyarrhythmia are made of the following Chinese medicinal materials: 10g ephedra, 10g aconite, 4g asarum, 32g roasted licorice, 14g ginseng, 12g cassia twig, 32g rehmannia glutinosa, 10g pear peel, safflower 12g, Polygonatum 10g, Keel 12g, Curcuma 14g, Astragalus 22g, Salvia miltiorrhiza 32g, Ginger 10g, Jujube 30g.

[0028] The preparation method is as follows:

[0029] Step 1: Take ephedra, aconite, asarum, roasted licorice, ginseng, cassia twig, rehmannia, pear skin, safflower, polygonatum, keel, turmeric, astragalus, salvia, ginger, jujube, a total of sixteen herbs, add 10 times water, decoct once, 2 hours each time, combine decoction after decoction is completed, filter;

[0030] Step 2: Concentrate the filtrate to 60°C with a relative density of 1.15g / mL, add ethanol to make the ethanol content reach 65%, stir while adding, let stand for 6 hours, take out the supernatant and recover ethanol, concentrate to a re...

Embodiment 2

[0035] The Fumailing Capsules for preventing and treating bradyarrhythmia are made of the following Chinese medicinal materials: 9g ephedra, 9g aconite, 3g asarum, 28g roasted licorice, 12g ginseng, 11g cassia twig, 28g rehmannia glutinosa, 9g pear peel, safflower 11g, Polygonatum 9g, Keel 11g, Curcuma 12g, Astragalus 20g, Salvia 30g, Ginger 9g, Jujube 28g.

[0036] The preparation method is as follows:

[0037] Step 1: Take ephedra, aconite, asarum, roasted licorice, ginseng, cassia twig, rehmannia, pear skin, safflower, polygonatum, keel, turmeric, astragalus, salvia, ginger, jujube, a total of sixteen herbs, add 14 times water, decocting twice, 2 hours each time, after the decoction is completed, combine the decoction and filter;

[0038] Step 2: Concentrate the filtrate to 60°C with a relative density of 1.15g / mL, add ethanol to make the ethanol content reach 75%, stir while adding, let stand for 10 hours, take out the supernatant and recover ethanol, concentrate to a rel...

Embodiment 3

[0043] The Fumailing Capsules for preventing and treating bradyarrhythmia are made of the following Chinese medicinal materials: 8g ephedra, 8g aconite, 2g asarum, 25g roasted licorice, 10g ginseng, 10g cassia twig, 25g rehmannia glutinosa, 8g pear peel, safflower 10g, Polygonatum 8g, Keel 10g, Curcuma 10g, Astragalus 18g, Salvia miltiorrhiza 26g, Ginger 8g, Jujube 26g.

[0044] The preparation method is as follows:

[0045] Step 1: Take ephedra, aconite, asarum, roasted licorice, ginseng, cassia twig, rehmannia, pear skin, safflower, polygonatum, keel, turmeric, astragalus, salvia, ginger, jujube, a total of sixteen herbs, add 16 times water, decoct 3 times, 3 hours each time, combine the decoction after the decoction is completed, and filter;

[0046] Step 2: Concentrate the filtrate to 60°C with a relative density of 1.15g / mL, add ethanol to make the ethanol content reach 85%, stir while adding, let stand for 12 hours, take out the supernatant and recover ethanol, concentr...

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Abstract

The invention discloses a Fumailing capsule for preventing and treating slow arrhythmia and a preparation method of the Fumailing capsule. The capsule is prepared from the following traditional Chinese medicinal materials: 8-12g of ephedra, 8-10g of aconite roots, 2-4g of asarum herb, 25-32g of prepared liquorice roots, 10-14g of radix ginseng, 10-12g of ramulus cinnamomi, 25-32g of prepared rhizome of rehmannia, 8-10g of bretschneider pear pericarp, 10-12g of carthamus tinctorius, 8-10g of fragrant solomonseal rhizome, 10-12g of fossil fragment, 10-14g of curcuma roots, 18-22g of astragalus mongholicus, 26-32g of salvia miltiorrhiza, 8-10g of ginger and 26-30g of Chinese dates. Fumailing particles prepared from the traditional Chinese medicinal materials such as the ephedra, the aconite roots and the asarum herb are used for preventing and treating the slow arrhythmia; the materials are easy to obtain; the preparation method is simple; and the Fumailing capsule has a significant treatment effect on the arrhythmia, takes effect quickly, is safe to use and has no toxic or side effects, and can improve a sinoatrial node function and prevent and treat sinoatrial node hypofunction caused by various reasons.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a Fumailing capsule for preventing and treating bradyarrhythmia and a preparation method thereof. Background technique [0002] Bradyarrhythmia is more common clinically, and it is a group of syndromes caused by cardiac sinus node and atrioventricular junction lesions that lead to cardiac pacing and conduction dysfunction, resulting in a variety of arrhythmias and clinical symptoms, including sinus rhythm Bradycardia, sick sinus syndrome, atrioventricular block, etc., seriously affect the quality of life of patients, and even endanger their lives. [0003] At present, there is no specific drug for the clinical treatment of bradyarrhythmia. In severe cases, permanent cardiac pacemakers will be placed in the end. The role of cardiac pacemakers in the treatment of severe and fatal bradyarrhythmias is certain and irreplaceable. , saved the lives of many patients. However, in tradi...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K36/9068A61P9/06A61K35/02
CPCA61K9/1652A61K35/02A61K36/17A61K36/258A61K36/268A61K36/286A61K36/481A61K36/484A61K36/537A61K36/54A61K36/714A61K36/725A61K36/73A61K36/804A61K36/8969A61K36/9066A61K36/9068A61K2236/331A61K2236/51A61P9/06A61K2300/00
Inventor 叶莎高洁杨翠玲段宗明张岁龙郑敏英
Owner SECOND AFFILIATED HOSPITAL OF COLLEGE OF MEDICINEOF XIAN JIAOTONG UNIV
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