Potassium-enriched small wheat peptide with high blood pressure lowering effect and preparation method thereof

A high blood pressure and potassium-rich technology, applied in the biological field, achieves the effects of good social and economic benefits, easy preparation and low cost

Inactive Publication Date: 2017-11-07
ANHUI BIOLOGICAL PEPTIDE IND RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is worth noting that these trace elements must usually be directly or indirectly supplied by the soil, but most people often cannot obtain enough trace elements through diet

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038]Preparation of potassium-rich wheat small peptide: Dissolve potassium chloride (or potassium gluconate, or potassium lactate) in deionized water to prepare a solution with a concentration of 12 mg / ml, and add wheat at a ratio of 10:1 between the solution and wheat protein Egg white, stir evenly, heat and boil for 15 minutes, wait to cool to about 45°C, adjust the pH value to 2.0 with dilute hydrochloric acid, add 1.5% pepsin, keep warm for 2 hours, adjust the pH value to 8.0, add 1.0% trypsin, keep warm for 4 hours, Boil for 15 minutes, centrifuge, discard the precipitate, ultrafilter the supernatant through an ultrafiltration membrane with a relative molecular mass of 3KD, add the permeate to a DA201-C macroporous adsorption resin column, elute with water, and discard the washing solution , then elute with 75% (V / V) ethanol, collect the ethanol eluate, recover ethanol under reduced pressure and continue to concentrate to a relative density of 1.12 (60°C), spray dry (inle...

Embodiment 2

[0040] Preparation of potassium-rich wheat small peptides: Dissolve potassium chloride (or potassium gluconate, or potassium lactate) in deionized water to prepare a solution with a concentration of 14 mg / ml, and add wheat at a ratio of 8:1 between the solution and wheat protein Egg white, stir evenly, heat and boil for 10 minutes, wait to cool to about 50°C, adjust the pH value to 3.0 with dilute hydrochloric acid, add 2% pepsin, keep warm for 3 hours, adjust the pH value to 7.5, add 2% trypsin, keep warm for 5 hours, Boil for 10 minutes, centrifuge, discard the precipitate, ultrafilter the supernatant through an ultrafiltration membrane with a relative molecular mass of 3KD, add the permeate to a DA201-C macroporous adsorption resin column, elute with water, and discard the washing solution , then elute with 60% (V / V) ethanol, collect the ethanol eluate, recover ethanol under reduced pressure and continue to concentrate to a relative density of 1.15 (60°C), spray dry (inlet a...

Embodiment 3

[0042] Get the potassium-rich wheat small peptide 100g of embodiment 1 method gained, press potassium-rich wheat small peptide: corn oil: beeswax: lecithin ratio is 10:35:4:1 mixed material, through grinding 30 minutes, with gelatin, purified water , glycerin, and iron oxide black in the ratio of 100:100:40:1 to make soft capsule skin glue, control the temperature of the plastic box at 40-50°C, the temperature of the heat preservation tank at 35-45°C, and the temperature of the spray body at 30-40°C, and press it into a soft capsule. Capsules, the content of each capsule weighs 0.45g, dried in cold air at 17°C-27°C for 3-5h to finalize the shape, washed pills, dried, selected pills, packed, and prepared into finished soft capsules.

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Abstract

The invention discloses potassium-enriched small wheat peptide with a blood pressure lowering effect and a preparation method thereof, and belongs to the field of biotechnology. The potassium-enriched small wheat peptide is characterized by being prepared from wheat protein as a starting material through chelating enzymolysis, performing ultrafiltration, resin column purification, concentrated under reduced pressure, and spray drying. The wheat protein can be used as a main raw material, the other raw materials and auxiliary materials are added, and according to the conventional preparation method, a series of corresponding preparations are prepared. A synchronous method of enzymolysis and enrichment, adopted by the invention, has the characteristics of high enrichment efficiency and high element organizing efficiency; the potassium-enriched small wheat peptide can significantly lower high blood pressure.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a potassium-rich wheat small peptide with the effect of reducing high blood pressure and a preparation method thereof. Background technique [0002] Hypertension (hypertension) refers to an increase in systemic arterial blood pressure (systolic and / or diastolic) as the main feature (systolic blood pressure ≥ 140 mm Hg, diastolic blood pressure ≥ 90 mm Hg), which may be accompanied by heart, brain, kidney, etc. Clinical syndrome of functional or organic damage to organs. Hypertension is the most common chronic disease and the main risk factor for cardiovascular and cerebrovascular diseases. Symptoms of high blood pressure vary from person to person. In the early stage, there may be no symptoms or no obvious symptoms. The common ones are dizziness, headache, neck tightness, fatigue, and heart palpitations. Blood pressure rises only after fatigue, mental stress, and mood swings, and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23J3/18A23J3/34A23L33/10A23L33/115A23L33/18A61K38/01A61P9/12
CPCA23J3/18A23J3/346A23L33/10A23L33/115A23L33/18A23V2002/00A61K38/00A61K38/01A23V2200/30
Inventor 柏道鸣刘玉军卢宁
Owner ANHUI BIOLOGICAL PEPTIDE IND RES INST
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