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Lipid-lowering dispersible tablets and preparation technology thereof

A preparation process and a technology for dispersible tablets, which are applied in the field of Jiangzhiling dispersible tablets and the preparation process thereof, can solve the problems of low extraction rate of stilbene glycosides, affecting the curative effect of preparations, waste of resources and the like

Active Publication Date: 2012-11-14
ZHEJIANG WECOME MEDICINE IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] In addition, the above-mentioned process did not scientifically design the extraction route according to the composition of the raw materials, resulting in poor extraction efficiency, especially the low extraction rate of the active ingredient stilbene glycosides in Polygonum multiflorum, resulting in waste of resources and affecting the efficacy of the preparation

Method used

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  • Lipid-lowering dispersible tablets and preparation technology thereof
  • Lipid-lowering dispersible tablets and preparation technology thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0087] Weigh the following raw materials:

[0088] Polygonum multiflorum 222g, wolfberry fruit 222g, sealwort 296g, hawthorn 148g, cassia seed 44g, carboxymethyl starch sodium 110g, silicon dioxide 180g, magnesium stearate 2g.

[0089] The preparation process is as follows:

[0090] (1) Take Polygonatum and Lycium barbarum and decoct twice, add 10 times the amount of water for the first time, extract for 2 hours, add 8 times the amount of water for the second time, extract for 1 hour, filter, combine the filtrates, and concentrate to Clear ointment I with a relative density of 1.20-1.25 at 75°C, set aside;

[0091] (2) Crush hawthorn and cassia seeds, pass through a 50-mesh sieve, add 5 times the amount of ethanol / ethyl acetate mixture (the volume ratio of ethanol to ethyl acetate is 12:1) and soak for 30 minutes, and output it with microwave under stirring Irradiate at 625w for 10 minutes for extraction, filter, and concentrate the filtrate to extract II;

[0092] (3) Put ...

Embodiment 2

[0097] Weigh the following raw materials:

[0098] Polygonum multiflorum 177g, medlar 177g, sealwort 236g, hawthorn 118g, cassia seed 35g, carboxymethyl starch sodium 88g, silicon dioxide 144g, magnesium stearate 1.6g;

[0099] The preparation process is as follows:

[0100] (1) Take Polygonatum and wolfberry and add water to decoct twice, add 10 times the amount of water for the first time, extract for 2.5 hours, add 8 times the amount of water for the second time, extract for 0.5 hours, filter, combine the filtrates, and concentrate to Clear ointment I with a relative density of 1.20-1.25 at 75°C, set aside;

[0101] (2) Crush hawthorn and cassia seeds, pass through a 50-mesh sieve, add 5 times the amount of ethanol / ethyl acetate mixture (the volume ratio of ethanol to ethyl acetate is 8:1) and soak for 20 minutes, and output it with microwave under stirring. Irradiate at 600w for 8 minutes to extract, filter, and concentrate the filtrate to extract II;

[0102] (3) Put R...

Embodiment 3

[0107] Weigh the following raw materials:

[0108] Polygonum multiflorum 266g, medlar 266g, sealwort 355g, hawthorn 178g, cassia seed 53g, carboxymethyl starch sodium 132g, silicon dioxide 216g, magnesium stearate 2.4g;

[0109] The preparation process is as follows:

[0110] (1) Take Polygonatum and Lycium barbarum and add water to decoct twice, add 10 times the amount of water for the first time, extract for 2 hours, add 12 times the amount of water for the second time, extract for 1.5 hours, filter, combine the filtrates, and concentrate to Clear ointment I with a relative density of 1.20-1.25 at 80°C, set aside;

[0111] (2) Crush hawthorn and cassia seeds, pass through a 50-mesh sieve, add 6 times the amount of ethanol / ethyl acetate mixture (the volume ratio of ethanol to ethyl acetate is 16:1) and soak for 40 minutes, and output with microwave under stirring Irradiate at 650w for 12 minutes for extraction, filter, and concentrate the filtrate to extract II;

[0112] (...

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Abstract

The invention discloses lipid-lowering dispersible tablets and a preparation technology thereof. The lipid-lowering dispersible tablets comprise the following ingredients: 177-266 weight portions of prepared polygonum multiflorum, 177-266 weight portions of wolfberry, 236-355 weight portions of polygonatum rhizome, 118-178 weight portions of haw, 35-53 weight portions of cassia seed, 88-132 weight portions of sodium carboxy methyl starch, 144-216 weight portions of silica, and 1.6-2.4 weight portions of magnesium stearate. The present invention has the advantage of convenient administration, safety, reliable and fast effect, high bioavailability, capability of being used for a long period, and no toxic and side effect, and is the first choice in hyperlipidemia patients. The invention alsohas the advantages of simple preparation, low cost, and the like, and is suitable to people of all ages.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine and the field of traditional Chinese medicine processing, in particular to a Jiangzhiling dispersible tablet and a preparation process thereof. Background technique [0002] Hyperlipidemia is a commonly used term for abnormal lipid metabolism, mainly referring to excessive serum total cholesterol (TC) or triglyceride (TG) levels and / or low serum high-density lipoprotein cholesterol (HDL-C) levels. In recent years, with the increase of people's income and continuous improvement of living standards, great changes have taken place in the food structure, and more and more high-protein, high-cholesterol and high-sugar foods are consumed, resulting in a sharp increase in the number of people with hyperlipidemia. [0003] Dyslipidemia is an important independent risk factor for coronary heart disease. Once a patient develops symptoms of hyperlipidemia, he or she often develops cardiovascular a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8969A61K9/20A61K47/36A61P3/06
Inventor 刘忠良
Owner ZHEJIANG WECOME MEDICINE IND
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