Inflammation-diminishing paste for dental pulp, and preparation method of inflammation-diminishing paste

An anti-inflammatory paste and dental pulp technology, applied in the field of pharmaceutical compositions, can solve the problems of tooth loss of sensation and defense function, tooth tissue becoming brittle, tooth loss of vitality, etc., achieve good anti-bacterial and anti-inflammatory effects, less follow-up visits, and promote healing effect

Inactive Publication Date: 2017-01-11
AFFILIATED STOMATOLOGICAL HOSPITAL OF NANJING MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to aim at the nutrient metabolism of the existing pulp tissue during root canal treatment, only the periodontal tissue is supplied, and the tooth loses vitality and discoloration, and at the same time the tooth loses sensory and defense functions, and the tooth tissue becomes brittle and easily In order to solve the problem of fracture, we invented a kind of dental pulp that can effectively treat a variety of periapical lesions including irreversible pulpitis, preserve the vitality of pulp tissue, promote the regression of inflammation, the regeneration of pulp tissue and The pulp anti-inflammation paste for restoring its function and providing a corresponding preparation method at the same time

Method used

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  • Inflammation-diminishing paste for dental pulp, and preparation method of inflammation-diminishing paste
  • Inflammation-diminishing paste for dental pulp, and preparation method of inflammation-diminishing paste
  • Inflammation-diminishing paste for dental pulp, and preparation method of inflammation-diminishing paste

Examples

Experimental program
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Effect test

Embodiment 1

[0031] The pulp anti-inflammatory paste of this embodiment includes a paste base and an active ingredient, and the active ingredients are as follows: 10 g of iodoform, 10 g of metronidazole, 10 g of ciprofloxacin, 5 g of chitosan, and 35 mL of the paste base olive oil.

[0032] The pulp anti-inflammatory paste of the present embodiment is prepared by the following method:

[0033] 1) Grinding iodoform, metronidazole, ciprofloxacin and chitosan into fine powder, passing through a 100-mesh sieve to obtain powder;

[0034] 2) Add the paste base to the powder prepared above, mix and stir until creamy, and obtain a uniformly stirred paste preparation;

[0035] 3) Sterilize and repack the obtained paste preparation;

[0036] 4) Store the subpackaged sterilizing paste in a dry, cool and dark place for later use.

Embodiment 2

[0038] The pulp anti-inflammatory paste of the present embodiment includes a paste base and active ingredients, and the active ingredients are as follows: 25 g of iodoform, 25 g of metronidazole, 25 g of ciprofloxacin, 15 g of chitosan, and 135 mL of the paste base olive oil.

[0039] The preparation method is the same as in Example 1.

Embodiment 3

[0041] The pulp anti-inflammatory paste of this embodiment includes a paste matrix and active ingredients, and the active ingredients are as follows: 40 g of iodoform, 40 g of metronidazole, 40 g of ciprofloxacin, 20 g of chitosan, and 170 mL of the paste base Methicone.

[0042] The preparation method is the same as in Example 1.

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Abstract

The invention provides an inflammation-diminishing paste for dental pulp. The inflammation-diminishing paste for the dental pulp is prepared from an active ingredient; the active ingredient is prepared from the following components in parts by weight: 10-40 parts of iodoform, 10-40 parts of metronidazole, 10-40 parts of ciprofloxacin and 5-20 parts of chitosan. The inflammation-diminishing paste for the dental pulp has the technical effects that 1, the inflammation-diminishing paste has better antibacterial and anti-inflammatory effects, is stable and lasting in efficacy and high in permeability, and is capable of promoting the recovery of normal physiological functions of the dental pulp, thus remarkably improving the success rate of vital pulp preservation of diseased teeth; 2, during clinical use, compared with the traditional root canal therapy, the inflammation-diminishing paste for the dental pulp is simple and convenient in operation by oral clinical doctors and short in treatment time; after the inflammation-diminishing paste for the dental pulp is used, the subsequent visit times of a patient are reduced, and the treatment efficiency of dental pulp diseases is greatly increased. Mechanical preparation does not need to be carried out, so that root canal wall tissues are prevented from being damaged for a second time, and the risk of fracture of teeth is reduced.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to a dental pulp anti-inflammatory paste, in particular to a dental pulp anti-inflammatory paste and a preparation method thereof. The paste has strong bactericidal effect, can improve tissue repair ability, and can inhibit bacterial reproduction, and has significant curative effect on various diseases such as pulp inflammation. Background technique [0002] Pulp is the loose connective tissue located in the pulp cavity of the tooth, surrounded by hard dentin. Factors such as dental caries, tooth trauma, and abnormal tooth structure can lead to infection and necrosis of the dental pulp. Once the pulp is inflamed, it often Not easy to cure. At present, for teeth with pulp disease, root canal treatment is usually performed clinically to completely remove the entire pulp tissue. After root canal treatment, the nutrition metabolism of the tooth is only supplied by the periodontal tissue...

Claims

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Application Information

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IPC IPC(8): A61K33/18A61K9/06A61P1/02A61K31/4164A61K31/496A61K31/722
CPCA61K9/06A61K31/4164A61K31/496A61K31/722A61K33/18A61K47/44A61K2300/00
Inventor 于金华庞希瑶周洲金琳
Owner AFFILIATED STOMATOLOGICAL HOSPITAL OF NANJING MEDICAL UNIV
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