4 results about "CLAVULANATE POTASSIUM" patented technology

This invention discloses a powder containing doxycycline hydrochloride and potassium clavulanate for aquaculture, its preparation method, and its application, belonging to the field of biotechnology. This invention combines doxycycline hydrochloride and potassium clavulanate to enhance the antibacterial ability of aquatic animals against drug-resistant bacteria, thereby better treating various diseases caused by drug-resistant bacteria in aquatic animals. Further experiments demonstrate that potassium clavulanate can significantly reduce bacterial resistance and enhance the antibacterial activity of doxycycline hydrochloride. The preparation of a composite powder using the combination of doxycycline hydrochloride and potassium clavulanate is simple, uses readily available raw materials, and is suitable for large-scale industrial production. Its application in the treatment of aquatic animal diseases, verified through challenge experiments, demonstrates the effectiveness of this composite powder in treating bacterial infections in aquatic animals. It has broad application prospects.

The application provides a spherical potassium clavulanate, a preparation method thereof and a compound preparation. The spherical potassium clavulanate has a spherical diameter of 25-150 microns. The preparation method of the spherical potassium clavulanate is as follows: 1. Dissolving a tertiary butylamine salt in an organic solvent to obtain an amine salt solution; 2. Preparing a potassium isooctanoate solution by dissolving potassium isooctanoate in an appropriate amount of organic solvent; 3. Removing carbon in the solution by adding activated carbon into the amine salt solution, stirring, filtering and washing the carbon with a small amount of organic solvent; 4. Crystallizing by controlling the temperature of the crystallization solution at 16-20 DEG C, stirring and adding the potassium isooctanoate solution at a constant speed; after the addition is completed, the temperature is lowered to 2-6 DEG C, and the stirring and heat preservation are performed for greater than or equal to 2 hours; 5. Filtering, washing and drying by filtering the crystallization solution, washing the solution with a solvent at 2-6 DEG C for 3-4 times, and vacuum drying the wet powder by cold pumping for 1 hour and drying at 35 DEG C for 6 hours. The spherical potassium clavulanate prepared by the method has uniform particle size distribution, good fluidity, easy dispensing and quality meeting the standard of the 2020 edition of the Chinese Pharmacopoeia.

The invention discloses amoxicillin sodium and clavulanate potassium for injection and a preparation method of the amoxicillin sodium and clavulanate potassium, and relates to the technical field of pharmaceutical preparations. The preparation method comprises the following steps: adding vitamin E acetate and poloxamer 124 into absolute ethyl alcohol, and uniformly mixing to obtain a mixed solution A; adding amoxicillin sodium and potassium clavulanate into the mixed solution, and uniformly mixing to obtain a mixed solution B; and adding the mixed solution B into a spray dryer, and carrying out spray drying in an inert dry atmosphere to obtain the amoxicillin sodium and clavulanate potassium powder. Vitamin E acetate and poloxamer 124 are added into medicine molecules, and the inlet and outlet temperatures are controlled in cooperation with a spray drying process, so that the amoxicillin sodium and clavulanate potassium powder is obtained. The stability of amoxicillin sodium and clavulanate potassium for injection can be effectively improved.

The invention provides a preparation method of an amoxicillin and clavulanate potassium tablet, and belongs to the technical field of medicinal chemistry. Amoxicillin and potassium clavulanate-microcrystalline cellulose are used as main drugs, the mass ratio of amoxicillin to potassium clavulanate in the potassium clavulanate-microcrystalline cellulose is 1: 1, the mass ratio of amoxicillin to potassium clavulanate is 4: 1, microcrystalline cellulose, magnesium stearate, sodium hydroxymethyl starch, colloidal silicon dioxide, dry yeast and erythrosine aluminum lake are used as auxiliary materials, and the auxiliary materials are used as auxiliary materials. The invention can give consideration to stability, impurity control and palatability.