Pharmaceutical composition containing amoxicillin trihydrate and clavulanate potassium
A technology of amoxicillin trihydrate and potassium clavulanate, which is applied in the field of novel sustained-release pharmaceutical preparations and can solve the problems of no pharmaceutical-grade product supply and the like
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[0046] The modified release formulation containing amoxicillin trihydrate and clavulanic acid potassium (weight ratio is 16: 1) of the present invention is a sustained-release three-layer tablet, wherein the weight is based on amoxicillin anhydrous and clavulanic acid respectively, Layer 1 is an immediate release layer containing potassium clavulanate and part of amoxicillin trihydrate; layer 2 is an immediate release layer containing part of amoxicillin trihydrate; layer 3 is a sustained release layer containing the rest of amoxicillin trihydrate.
[0047] The prescription is as follows:
[0048] Potassium Amoxicillin Clavulanate (2:1)
[0049] (Based on amoxicillin anhydrous and clavulanic acid) 93.75g
[0050] Layer 1 sodium starch glycolate 7.0g
[0051] Magnesium Stearate 2.0g
[0052] Micronized silica gel 1.0g
[0053]Amoxicillin trihydrate (calculated as anhydrous substance) 161.5g
[0054] Microcrystalline Cellulose 40.0g
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