Medicinal composition, as well as preparation process and application thereof

A composition and drug technology, applied in the direction of drug combination, active ingredients of heterocyclic compounds, antibacterial drugs, etc., can solve problems such as compound preparations that have not yet been seen, and achieve good therapeutic effect, convenient use, and quick effect

Active Publication Date: 2013-01-02
JIUJIANG DACHENG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

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Method used

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  • Medicinal composition, as well as preparation process and application thereof
  • Medicinal composition, as well as preparation process and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Embodiment 1 5% compound amoxicillin soluble powder I

[0046](1) Weigh 5kg of amoxicillin, 5kg of potassium clavulanate, 5kg of ambroxol hydrochloride and 85kg of anhydrous glucose, pass through 80-mesh sieve respectively, and set aside.

[0047] (2) Take the sieved amoxicillin and potassium clavulanate and mix them fully in a V-type mixer for 20 minutes, take the sieved ambroxol hydrochloride and add them to the above mixture and mix them fully in a V-type mixer for 20 minutes.

[0048] (3) Then add the sieved anhydrous glucose into the above-mentioned mixture of amoxicillin, potassium clavulanate and ambroxol hydrochloride, fully mix in a two-dimensional mixer for 30 minutes, discharge and pack to obtain the obtained 5% compound amoxicillin soluble powder.

Embodiment 2

[0049] Embodiment 2 5% compound amoxicillin soluble powder II

[0050] (1) Weigh 5kg of amoxicillin, 1kg of potassium clavulanate, 1kg of ambroxol hydrochloride and 93kg of anhydrous glucose, pass through 80-mesh sieve respectively, and set aside.

[0051] (2) Take 5kg of sieved amoxicillin and 5kg of anhydrous glucose, add them to a small V-shaped mixer and mix for 5 minutes, continue to add 10kg of anhydrous glucose and mix for 5 minutes to obtain material A; add 1kg of potassium clavulanate and 1kg of anhydrous glucose to a small Mix in a V-type mixer for 5 minutes to obtain material B; add 1 kg of ambroxol hydrochloride and 1 kg of anhydrous glucose to a small V-type mixer and mix for 5 minutes to obtain material C, and add A, B, and C to a larger V-type mixer for mixing 20min, obtain mixture 1;

[0052] (3) Then add the sieved remaining anhydrous glucose to the above mixture 1, fully mix in a larger V-shaped mixer for 30 minutes, discharge, and pack to obtain the 5% comp...

Embodiment 3

[0053] Example 3 5% compound amoxicillin soluble powder III

[0054] (1) Weigh 5kg of amoxicillin, 5kg of potassium clavulanate, 1kg of ambroxol hydrochloride and 89kg of corn starch, pass through 80-mesh sieve respectively, and set aside.

[0055] (2) Take the sieved amoxicillin and potassium clavulanate and mix them fully in a V-type mixer for 20 minutes, take the sieved ambroxol hydrochloride and add them to the above mixture and mix them fully in a V-type mixer for 20 minutes.

[0056] (3) Add the sieved cornstarch to the above-mentioned mixture of amoxicillin, potassium clavulanate and ambroxol hydrochloride, fully mix in a two-dimensional mixer for 30 minutes, discharge, and pack to obtain the 5% compound amoxicillin soluble powder III.

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Abstract

The invention discloses a medicinal composition, which comprises the following components in parts by weight: 5 to 15 parts of amoxicillin, 1 to 5 parts of clavulanate potassium, and 1 to 5 parts of ambroxol hydrochloride. The invention discloses an application of the medicinal composition in preparing medicaments for treating animal respiratory infectious diseases, in particular for preparing porcine infectious pleuropneumonia and haemophilusparasuis. The invention also discloses a preparation method of compound amoxicillin soluble powder. The compound amoxicillin soluble powder comprises the following components in parts by weight: 5 to 15 parts of amoxicillin, 1 to 5 parts of clavulanate potassium, 1 to 5 parts of ambroxol hydrochloride, and 75 to 93 parts of glucosum anhydricum. The raw materials are uniformly mixed according to an equivalent incremental principle to obtain the compound amoxicillin soluble powder. The medicinal composition disclosed by the invention is reasonable and scientific in prescription, the bioavailability of amoxicillin can be increased compared with an amoxicillin preparation, the drug resistance is reduced, and the curative effect is improved.

Description

technical field [0001] The invention belongs to the field of animal health care and veterinary medicine, and in particular relates to a pharmaceutical composition containing amoxicillin and its preparation process and application. Background technique [0002] A large number of unscientific use of antibiotics in the prevention and treatment of animal diseases has caused bacteria to become less and less sensitive to commonly used antibiotics. Bacteria develop resistance to antibiotics through various ways, among which the production of β-lactamase and the hydrolysis of β-lactam rings in penicillins and cephalosporins are the main methods. The use of β-lactamase inhibitors can greatly improve the antibacterial activity of certain β-lactam antibiotics and expand the antibacterial spectrum. [0003] From 1999 to 2011, Professor Wang Hongning found that bacteria were resistant to tetracyclines, penicillins, macrolides, fluoroquinolones, and chloramphenicol during the detection ...

Claims

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Application Information

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IPC IPC(8): A61K31/43A61K31/424A61K31/137A61P11/00A61P11/10A61P31/04
Inventor 虞枫张文武温福华程玉祥
Owner JIUJIANG DACHENG PHARMA CO LTD
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