Amoxicillin or amoxicillin and clavulanate potassium instant chewable tablets for pet and preparation method for same

A technology of amoxicillin-clavulanate potassium and clavulanate potassium, which is applied in the field of amoxicillin or amoxicillin and clavulanate potassium instant chewable tablets for pets and its preparation, and can solve the problem that is not suitable for pet administration and other problems, to achieve the effect of convenient pet administration, overcoming small hardness, and simple preparation conditions

Inactive Publication Date: 2012-06-27
NANJING AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0016] Existing amoxicillin (containing amoxicillin / potassium clavulanate) veterinary marketed dosage forms include ordinary oral tablets, soluble powders, suspensions, etc., and amoxicillin or its combination with clavulanate potassium New compound dosage forms include amoxicillin sustained-release tablets, amoxicillin gastric retention tablets, etc., which are not suitable for pet administration

Method used

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  • Amoxicillin or amoxicillin and clavulanate potassium instant chewable tablets for pet and preparation method for same
  • Amoxicillin or amoxicillin and clavulanate potassium instant chewable tablets for pet and preparation method for same
  • Amoxicillin or amoxicillin and clavulanate potassium instant chewable tablets for pet and preparation method for same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032]

[0033]

[0034] Preparation: ① Pass the raw material of potassium amoxicillin-clavulanate, sorbitol, aspartame, and sodium lauryl sulfate through a 100-mesh sieve, and grind mannitol and pass through a 50-mesh sieve; ②Weigh amoxicillin-clavulanic acid Potassium, microcrystalline cellulose, sorbitol and aspartame are mixed evenly, and granules are prepared with 10% povidone K30 absolute ethanol solution, passed through a 50-mesh sieve, and dried at 50°C. Sodium alkyl sulfate, mannitol, and crospovidone are mixed evenly, sprayed with essence and left for 30 minutes, and pressed into tablets, each tablet weighing 0.4g.

[0035] Tablet hardness and friability inspection: Prepare three batches of samples according to Example 1, take 6 tablets from each batch, put them into the small box of the tablet four-purpose tester for examining the friability, shake for 1 minute, take out and observe Its friability results. Results: The average hardness of the three batches of...

Embodiment 2

[0038]

[0039] Preparation: ① Grind the raw materials of amoxicillin, low-substituted hydroxypropyl cellulose, aspartame, and sodium lauryl sulfate, pass through a 100-mesh sieve, grind sorbitol, and mannitol and pass through a 50-mesh sieve; ②Weigh Take amoxicillin-clavulanate potassium, microcrystalline cellulose, low-substituted hydroxypropyl cellulose and aspartame and mix them evenly, then make granules with 10% povidone K30 absolute ethanol solution, pass through a 50-mesh sieve, 50 After granulation, add sodium lauryl sulfate, micropowder silica gel, and sorbitol, mix well, spray the essence and leave it for 30 minutes, and press into tablets. Each tablet weighs 0.4g.

[0040] According to the method in Example 1, the average hardness of the three batches of samples in this example is respectively: 33.8Kg, 33.0Kg, and 34.1Kg; there are no fragments or cracks.

[0041] According to the method in Example 1, the average disintegration time of the three batches of samp...

Embodiment 3

[0043]

[0044] Preparation: ① Pass amoxicillin-clavulanate potassium raw materials, crospovidone, low-substituted hydroxypropyl cellulose, aspartame through a 100-mesh sieve, grind sorbitol and pass through a 100-mesh sieve; Potassium moxicillin clavulanate, crospovidone, sorbitol and aspartame are evenly mixed, then granulated with 10% povidone K30 absolute ethanol solution, passed through a 50-mesh sieve, dried at 50°C, and granulated, Add micropowder silica gel and low-substituted hydroxypropyl cellulose, mix well, spray the essence and leave it for 30 minutes, and press into tablets. Each tablet weighs 0.4g.

[0045] According to the method in Example 1, the average hardness of the three batches of samples in this example is respectively: 32.7Kg, 33.5Kg, and 32.3Kg; there are no fragments or lobes.

[0046] According to the method in Example 1, the average disintegration time of the three batches of samples in this example is 49.3s, 48.7s, and 48.4s.

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Abstract

The invention belongs to the field of veterinary medicine, and particularly relates to amoxicillin or amoxicillin and clavulanate potassium instant chewable tablets for pet and a preparation method for the same. The instant chewable tablets are the amoxicillin or amoxicillin and clavulanate potassium instant chewable tablets prepared by combining with orally disintegrating tablets fast in medicine release speed in oral cavity and bad in disintegrating crispness and chewable tablets chewable but slow in disintegrating and medicine release speeds on the basis of the present dosage form of amoxicillin or amoxicillin and clavulanate potassium, so that administration for pet is greatly facilitated, and the antibacterial characteristic of amoxicillin can be adequately exerted. The preparation method for the instant chewable tablets comprises the following steps of: crushing amoxicillin or amoxicillin and clavulanate potassium and related auxiliary materials, and passing through a sieve of 50-100 meshes at first; uniformly mixing the main medicine and the selected auxiliary materials in a proper ratio, and producing wet granules; and drying and straightening the granules, and then tabletting. The instant chewable tablets have broad-spectrum antimicrobial activity and can be used for preventing and treating the bacterial infection of pet. While being used, the preparation is placed in the mouth of pet and fast melted by chewing, so that the convenience and compliance of administration for pet are solved well.

Description

technical field [0001] The invention belongs to the field of veterinary medicine, and relates to amoxicillin or amoxicillin and clavulanate potassium instant chewable tablets for pets and a preparation method thereof. Background technique [0002] Amoxicillin, also known as amoxicillin, has a chemical name of (2S, 5R, 6R)-3,3-dimethyl-6-[(R)-(-)-2-amino-2-( 4-Hydroxyphenyl)acetamido]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid trihydrate, white or off-white crystalline powder, in Slightly soluble in water, slightly bitter taste, the chemical structure is as follows: [0003] [0004] Chemical molecular structural formula of amoxicillin [0005] Amoxicillin is a broad-spectrum semi-synthetic penicillin widely used in both medical and veterinary clinics. It has a broad-spectrum bactericidal effect, and its effect on Gram-positive bacteria such as Streptococcus, Staphylococcus, Clostridium, Corynebacterium, Fusobacterium, Erysipelothrix, Actinomyces, Listeri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/43A61P31/04A61K31/424
Inventor 余祖功王俊丽赵艳兵
Owner NANJING AGRICULTURAL UNIVERSITY
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