204results about How to "Reduce skin irritation" patented technology

The present invention relates to compositions for use in analyte monitoring devices. These compositions are useful to increase the flux of analyte across skin, tissue or mucosal surfaces. The compositions include hydrogels and collection reservoir systems comprising ionically conductive materials. The present invention also includes methods of making / manufacturing hydrogels or collection reservoir systems, collection assemblies comprising the hydrogels, electrode assemblies in combination with the hydrogels or collection reservoir systems, and methods of using the same.

An agent delivery or sampling device (2) comprising a member (6) having a plurality of blades (4) for piercing the skin and a connecting medium (65) covering at least a part of the skin contacting side (48) of the member (6) for increasing transdermal flux of an agent.

A method of treating a patient for ventricular tachycardia using a wearable defibrillator includes monitoring the patient for a predetermined condition via one or more electrodes on the defibrillator, sending a message to the patient in response to the predetermined condition, activating the defibrillator so that the defibrillator delivers defibrillation energy to the patient, and storing at least one of the results of the monitoring, sending and activating steps in a memory on the defibrillator. The method also includes downloading information stored in the memory of the defibrillator to a base station having an external interface, and transmitting the information downloaded from the memory of the base station to an external location via the external interface of the base station.

Antimicrobial compositions having a rapid antiviral and antibacterial effectiveness, and a persistent antiviral effectiveness, are disclosed. The antimicrobial compositions contain (a) a disinfecting alcohol, (b) a blend containing a C12 to C22 alcohol and an ethoxylated C12 to C22 alcohol, such as a cetearyl alcohol and cetereth-20 blend, a cetearyl alcohol, steareth-20, and steareth-10 blend, or a mixture thereof, (c) an optional organic acid, and (c) water.

A transdermal drug delivery system is disclosed, which includes a polymer, a drug and an amount of a quaternary ammonium salt that is sufficient to act as a penetration enhancer. The quaternary ammonium salt may also be present in an amount sufficient to act as an irritation reducer. Further, the transdermal drug delivery system may also contain a co-enhancer, which provides a synergistic skin permeation enhancing effect when combined with the quaternary ammonium salt. A method for enhancing the transdermal delivery of a drug is also disclosed.

A transdermal contraceptive delivery system (TCDS) for fertility control in women is described. It comprises a backing layer, an adjoining layer of a solid absorption adhesive polymer matrix in which effective daily doses of an estrogen and a progestin are dispersed and released for transdermal absorption. Presently preferred is the use of the synthetic estrogen, ethinyl estradiol, and the synthetic progestin, levonorgestrel. Along with these two steroidal contraceptive agents, a combination of several chemical skin permeation enhancing agents, including capric acid, blended at specific weight ratios, ranging from 2:1:1:0.8 to 6:1:1:0.8, are homogeneously dispersed in the adhesive polymer matrix. The invention also provides a method of fertility control utilizing the transdermal contraceptive delivery system.

An adhesive composition for medical adhesive tapes, comprising a base polymer containing a pressure-sensitive adhesive polymer obtained by crosslinking or curing a precursor containing a urethane acrylate oligomer and an ultraviolet (UV) initiator, the base polymer having a glass transition temperature (Tg) of 0° C. or less.

Disclosed is a transdermal delivery system of multiple adhesive layers having a drug-free adhesive layer as an intermediate layer to control drug delivery rate. The transdermal delivery system enhances transdermal delivery rate in the early stage after application on skin and provides sustained control of the drug delivery rate in the intermediate and later stages. Thus, the drug delivery rate effective for treatment can be controlled in a sustained manner.

A muscle support garment and method for applying compressive forces to muscles within a treatment area are disclosed. A band of stretchable wrap material is secured to the garment and is wound in an overlapping spiral manner on the inside of the garment, encircling the treatment area. The band of wrap material is longitudinally adjustable to vary its tension and the compressive forces applied, from external of the garment. Overlapping loop retainer structures secured inside the garment slidably entrain and retain the wrap material in an overlapping manner. The garment may include an inner liner.

In a nonwoven fiber assembly which comprises a fiber comprising a thermal adhesive fiber under moisture and in which the fiber are entangled with each other, the fibers are bonded at contacting points of the fibers by melting the thermal adhesive fiber under moisture to distribute the bonded points approximately uniformly, thereby obtaining a buffer substrate. The buffer substrate may further comprises a conjugated fiber comprising a plurality of resins which are different in thermal shrinkage and form a phase separation structure, and the conjugated fibers may have an approximately uniform crimps having an average curvature radius of 20 to 200 μm and are entangled with the fibers constituting the nonwoven fiber assembly. The buffer substrate can be obtained by a method comprising the steps of: forming a web from the fiber comprising the thermal adhesive fiber under moisture; and subjecting the obtained fiber web to a heat and moisture treatment with a high-temperature water vapor to melt the thermal adhesive fiber under moisture for bonding the fibers. The buffer substrate has a high air-permeability, an excellent cushion property and softness.

The invention relates to a detector and a method, adapted for detecting a birefringent object near a surface, and to a shaving device adapted for detecting and for cutting a hair near a skin surface of a human body part or an animal body part. The detector (26) comprises a source (27) adapted for emitting optical radiation comprising at least a first wavelength, a second wavelength and an incident polarization state, and an imaging unit (28) adapted for imaging the birefringent object near the surface, wherein the imaging unit (28) comprises a detection unit (29) adapted for detecting optical radiation scattered and / or reflected by the birefringent object and / or the surface at the first wavelength and at the second wavelength, and a control unit adapted for processing a signal from the detection unit (29) for discrimination between the birefringent object and the surface, wherein the detection unit (29) is arranged for detecting scattered and / or reflected optical radiation coming from the birefringent object and / or the surface, comprising a first polarization state corresponding to the incident polarization state and a second polarization state being different from the first polarization state. In this way, detection efficiency and thus shaving quality are increased, at the same time energy consumption is reduced and also shaving safety is improved.

A personal cleansing composition exhibiting enhanced skin feel (i.e., enhanced skin softness, reduced skin irritation, reduced residue, and reduced greasy, tacky, or tight skin feel), enhanced foaming and lather, and good cleansing, more specifically, a personal cleansing composition comprising a mixture of alpha sulfonated alkyl esters or sulfonated fatty acids, or salts thereof, with an alkyl sulfoacetate or ethoxylated alkyl sulfoacetate, or salts thereof, secondary surfactants, and optional additives.

A method for automatically detecting atrial fibrillation in a non-standard ECG signal having changing morphology and containing significant muscle noise generated by an ambulatory subject is provided. A morphology independent QRS detector is used to compute R-R intervals in the ECG signal. The variance of the R-R intervals over a sliding window is normalized and compared with a threshold to determine if atrial fibrillation is present within the window.

A compression garment including a thermal energy regulating fabric. The compression garment has a first region of a first compression pressure. A second region adjacent a first side of the first region includes a first compression gradient increasing in compression pressure in a direction toward the first region. A third region adjacent a second side of the first compression region includes a second compression gradient increasing in compression pressure in a direction toward the first region. The first region includes a consistent compression pressure that is a higher pressure than or the highest pressure of the adjacent increasing pressure gradients.

The object of the present invention is to provide a non-woven fabric comprising a glass fiber which has a strength, flexibility and water resistance, has less skin irritancy and a good surface decoration property, and a process for producing the same, more specifically, to provide a non-woven fabric for a gypsum board which is used as a reinforcing material for a gypsum board placed on one side or both sides of the gypsum board, and a process for producing the same. A non-woven fabric for a gypsum board comprising 20 to 60% by weight of a glass fiber, 10 to 50% by weight of an organic fiber and 10 to 50% by weight of a fibrous binder, which contains the organic fiber at least on a gypsum core contact surface, is provided.

An underarm garment liner for preventing a wearer's perspiration from soiling a garment is disclosed. The liner includes, in its simplest embodiment and in the following order, a non-woven layer, an air laid paper layer, a hygroscopic absorption layer, a water-impervious layer, and an adhesive layer. The non-woven layer is adapted for contacting the wearer's skin and to convey perspiration away from the skin through capillary action to the absorbent air laid paper layer, which draws moisture away from the non-woven layer and conveys the moisture to the hygroscopic absorption layer. The layers are all preferably adhered together through use of hot-melt adhesive, or the like. The water-impervious layer is comprised of a vapor-pervious “breathable” thermoplastic polymer to prevent heat buildup between the liner and the wearer. Deodorizers, antibacterial agents, aloe, vitamin E, and petrolatum may all be further included in the liner 10. A layer of release paper temporarily affixed to the adhesive layer, such that the release paper may be peeled away from the adhesive layer by the wearer in order to expose the adhesive layer prior to use.

A skin application sheet for being impregnated with a cosmetic preparation is provided which is suitable for a face mask and so on, and causes less irritation to skin, and has good application properties. A splittable conjugate fiber web containing at least 50% by mass of splittable conjugate fibers is placed on one surface or both surfaces of a hydrophilic nonwoven containing at least 50% by mass of hydrophilic fibers and hydroentanglement treatment is conducted to split the splittable conjugate fibers into ultrafine fibers with a fineness of 0.5 dtex and to form a ultrafine fiber layer containing at least 10% by mass of the ultrafine fibers and to integrate the hydrophilic nonwoven and the ultrafine fiber layer so that a sheet is obtained. This sheet is impregnated with the cosmetic preparation and used in such a manner that the ultrafine fiber layer is a skin contact surface.

The invention relates to a compound type cleaning solution which comprises a component A, a component B and pure water, wherein the component A is composed of at least one amphoteric surfactant with 8 or more carbon atoms, and accounts for 0.1-15% of the cleaning solution by mass; the component B is at least one anionic surfactant, non-ionic surfactant or cationic surfactant with 8 or more carbon atoms, and accounts for 1-30% of the cleaning solution by mass; and the balance is pure water. In the invention, the amphoteric surfactant and other surfactants are compounded to prepare a dish hand-washing detergent which has excellent functions of cleaning, efficacy enhancing, thickening, foaming, foam stabilizing and the like and is very favorable for improving the performance of the product such as detergency, viscosity, storage stability and the like. Moreover, the amphoteric surfactant is generally in a water-soluble liquid state and can be easily mixed in a formula solution, thus the industrialization of the product provided by the invention can be easily realized.

The transfer of antimicrobial agent from a cleaning substrate to the skin can be reduced resulting in reduced skin irritancy when the viscosity of the cleaning composition containing the antimicrobial is increased in viscosity. The transfer is measured by the Simulated Hand Transfer Method. The cleaning substrate is used to clean hard surfaces, especially bathroom surfaces such as toilets, and is attached to a cleaning implement. Also provided is a method of promoting a product having reduced skin irritancy.

Antioxidant cosmetic skin care compositions formulated to combat conditions associated with free radical damage and oxidative stress are provided. The compositions contain effective amounts of one of several active agents, including an agent derived from one or more of the plant species: Lycium barbarum, Punica granatum, Vitis vinifera, Aspalathus linearis, and Camellia Sinensis as well as cosmetically acceptable carriers. These cosmetic compositions find use in improving the appearance of aged or damaged skin.

A bone conduction hearing aid system for generating bone conduction vibrations is disclosed. The bone conduction hearing aid system has a hearing aid with a vibrator. The hearing aid system includes an interconnection unit to connect the hearing aid to the user. There is a coupling between the interconnection unit and the hearing aid to connect and disconnect the hearing aid to and from the interconnection unit. The interconnection unit has connection portion and contact plate portion. The connection portion and the contact plate portion are designed in one integral piece of continuous polymer material. The interconnection unit has a concave or planar adhesive surface that can be adhered to the skin on the head of the user without applying any specific pressure against the skin. The sound vibrations are transmitted from the vibrator to the hearing organ as bone conduction sound vibrations.

An antimicrobial composition is provided in which the skin irritation of isothiazolone type compound is decreased and the injection operation properties thereof is improved by forming it as an uniform solution. The composition contains isothiazolone type compound and a compound which decreases the skin irritation of the former in a molar ratio of 1:0.1-50 and is dissolved in a solvent.

A protein modified to improve its stability, said modified protein being coupled to a beta-1,3-glucan branched with beta-1,6-linkage is provided. A method for the production thereof and a cosmetic or dermatological composition comprising the modified protein are also provided. The modified protein shows an improved stability while retaining its activity and being free of skin irritation.

Methods and composition for treating or preventing an inflammatory dermatological disease or condition, such as psoriasis, in a subject are described. The methods involve topical applications to the subject a therapeutically effective amount of a composition comprising at least one indigo naturalis composition, beberine and a pharmaceutically acceptable carrier.

The present invention relates to novel anti-pain formulations and methods of their delivery. Anti-pain agents delivered in accordance with the methods of the invention have an improved clinical utility and therapeutic efficacy relative to other drug delivery methods, including oral, intramuscular and subcutaneous delivery. The methods of the present invention provide benefits and improvements over conventional drug delivery methods including dose sparing, increased drug efficacy, reduced side effects.

The invention encompasses nanoparticle assemblies and methods for preparing nanoparticle and compositions comprising such nanoparticles for use in topical or skin applications. The invention further encompasses methods of complexing various molecular and cellular entities to the nanoparticles using the resulting nanoparticles of the invention as delivery devices. The nanoparticles can be used for a variety of applications, such as treating cancer, targeting tumors, reducing the toxicity of a drug in vivo, increasing the efficacy of a complexed agent in vivo, protecting a complexed agent against degradation, increasing skin penetration and retention of drugs, and enhancing the water solubility / dispersibility of a drug or other agent.