93results about How to "Minimize irritation" patented technology

A water soluble, biodegradable ABA- or BAB-type tri-block polymer is disclosed that is made up of a major amount of a hydrophobic A polymer block made of a biodegradable polyester and a minor amount of a hydrophilic polyethylene glycol(PEG) B polymer block, having an overall average molecular weight of between about 2000 and 4990, and that possesses reverse thermal gelation properties. Effective concentrations of the tri-block polymer and a drug may be uniformly contained in an aqueous phase to form a drug delivery composition. At temperatures below the gelation temperature of the tri-block polymer the composition is a liquid and at temperatures at or above the gelation temperature the composition is a gel or semi-solid. The composition may be administered to a warm-blooded animal as a liquid by parenteral, ocular, topical, inhalation, transdermal, vaginal, transurethral, rectal, nasal, oral, pulmonary or aural delivery means and is a gel at body temperature. The composition may also be administered as a gel. The drug is released at a controlled rate from the gel which biodegrades into non-toxic products. The release rate of the drug may be adjusted by changing various parameters such as hydrophobic/hydrophilic component content, polymer concentration, molecular weight and polydispersity of the tri-block polymer. Because the tri-block polymer is amphiphilic, it functions to increase the solubility and/or stability of drugs in the composition.

A water soluble biodegradable ABA- or BAB-type triblock polymer is disclosed that is made up of a major amount of a hydrophobic polymer made of a poly(lactide-co-glycolide) copolymer or poly(lactide) polymer as the A-blocks and a minor amount of a hydrophilic polyethylene glycol polymer B-block, having an overall weight average molecular weight of between about 2000 and 4990, and that possesses reverse thermal gelation properties. Effective concentrations of the triblock polymer and a drug may be uniformly contained in an aqueous phase to form a drug delivery composition. At temperatures below the gelation temperature of the triblock polymer the composition is a liquid and at temperatures at or above the gelation temperature the composition is a gel or semi-solid. The composition may be administered to a warm-blooded animal as a liquid by parenteral, ocular, topical, inhalation, transdermal, vaginal, transurethral, rectal, nasal, oral, pulmonary or aural delivery means and is a gel at body temperature. The composition may also be administered as a gel. The drug is released at a controlled rate from the gel which biodegrades into non-toxic products. The release rate of the drug may be adjusted by changing various parameters such as hydrophobic/hydrophilic componenet content, polymer concentration, molecular weight and polydispersity of the triblock polymer. Because the triblock polymer is amphiphilic, it functions to increase the solubility and/or stability of drugs in the composition.

A new lens design and method of implantation uses the change in pupil diameter of the eye concurrent with the changes induced by a contraction of the ciliary muscle during the accommodative reflex, in order to assist in focusing of nearby objects. This new intraocular lens consists of two parts. The posterior part or haptic part is inserted behind the iris and in front of the natural lens or artificial implant. Its main purpose is to participate in the accommodative mechanism and to prevent excessive lateral movement and luxation of the lens. An anterior or optical part is made of flexible material and is placed before the iris. Its diameter is variable but should be large enough to cover the pupillary margins to some degree under various conditions of natural dilation. The anterior and posterior part of the lens are separated by a compressible circular groove in which the iris will settle. The diameter of this groove is slightly larger than the pupillary diameter measured under normal photopic daylight conditions and for distance vision. Since the pupil becomes smaller in near vision, the iris will exert a slight pressure at the level of the groove of the lens which will cause a progressive and evenly distributed flexing of the anterior part of the intraocular lens, as the diameter of the compressible circular groove slightly decreases. This flexing will induce an increase in refractive power which corresponds to a variable part of the amount necessary for focusing nearby objects.

An implantable medical device is provided for controlled drug delivery within the bladder, or other body vesicle. The device may include at least one drug reservoir component comprising a drug; and a vesicle retention frame which comprises an elastic wire having a first end, an opposing second end, and an intermediate region therebetween, wherein the drug reservoir component is attached to the intermediate region of the vesicle retention frame. The retention frame prevents accidental voiding of the device from the bladder, and it preferably has a spring constant selected for the device to effectively stay in the bladder during urination while minimizing the irritation of the bladder.

The present disclosure is directed towards a biomechanical implant and anterior, lateral or posterior instrumentation construct. The construct may be of unitary or modular construction, whereby a single molded construction can form the entire assembly, in which case the through holes may be adapted to receive a metallic insert for screw fixation; or alternatively be of a modular construction wherein the anterior/lateral instrumentation and intervertebral spacer are designed for removable locking engagement, one with the other, for insertion by the surgeon as a unitary construct. A unique feature of the construct resides within the instrumentation construction, whereby a single opening formed therein permits two bone screws, or the like fastener device, to be positioned within both the superior and inferior vertebral bodies surrounding the spacer implant, or, for example in the case of a corpectomy or diskectomy with cage insertion, wherein two screws can be fixed within a single vertebral body through a single through hole, and wherein the bone screws are constructed and arranged to cooperate with the retention plate so as to provide locking engagement, one to the other, with the retention plate, upon final fixation thereof. Screw retention elements of alternative shape, based upon the choice of vertical or horizontal orientation, based upon an opened figure eight design, are provided for insertion in a groove formed in the borehole of the instrumentation plate which allows insertion of each fixation element but will prevent a loosened fixation element from falling out of the plate.

A pharmaceutical or cosmeceutical mousse shampoo composition formulated for application to hirsute areas, such as the human scalp, and containing an active pharmaceutical ingredient as well as a cleansing agent is disclosed. Methods of treatment using the same and processes of preparing the same are also disclosed.

The present invention provides implantable ocular drug delivery devices. Generally, the devices have a distal portion with a coil shaped body member and a proximal portion which contacts the sclera. In one aspect, the coil-shaped body member includes a unique configuration including two coiled portions with different pitches, which improves insertion of the device into the eye. In another aspect, the device has a proximal portion that includes a unique cap configuration having a concave distal face that improves stabilization of the device in the eye. In another aspect, the device includes a transitional portion between the cap and the coil-shaped body member that also improves stabilization of the device in the eye. The invention also provides methods for inserting the medical device into the eye, and methods for the treatment of an ocular condition.

A pair of underwear for use by a male includes a fabric fashioned to form a boxer-brief type undergarment, the fabric having a bilateral symmetry and including a front panel. A rear panel is formed within the fabric and positioned immediately behind the front panel to form an internal pocket. A slit-shaped portal is formed within the rear panel for providing access to the internal pocket for depositing a scrotum and genitalia of the male. Finally, an external pouch extending outward from the front panel is provided as a depository for the genitalia of the male. The boxer-brief type undergarment minimizes perspiration and irritation, absorbs accidental leakage of fluid body waste, and eliminates exposure to the fluid body waste and stains on the body of the male. A thin layer of absorbent material can be included to minimize the effects of accidental leakage.

A system and method for treating subcutaneous histological features without affecting adjacent tissues adversely employs microwave energy of selected power, frequency and duration to penetrate subcutaneous tissue and heat target areas with optimum doses to permanently affect the undesirable features. The frequency chosen preferentially interacts with the target as opposed to adjacent tissue, and the microwave energy is delivered as a short pulse causing minimal discomfort and side effects. By distributing microwave energy at the skin over an area and adjusting power and frequency, different conditions, such as hirsuitism and telangiectasia, can be effectively treated.

A peroxide-containing dual component tooth-whitening system providing enhanced whitening efficacy, minimal gingival irritation, and tooth sensitivity is described. The system is comprised of a first component containing a peroxide compound and a peroxide-compatible abrasive and a second component containing an alkaline compound. When the components are combined and contact the surface of a tooth an enhanced whitening effect is obtained with minimal tooth sensitivity and gum irritation. A desensitizer compound, a color indicator, and a stabilizing carrier can be included in the system. In certain embodiments, the composition is substantially free of chelating agents.

A method and to treat dysrhythmias of the heart, for example atrial fibrillation, by creating artificial conduction pathways, fields or patterns. These artificial pathways or fields are created by injecting materials having desired electrical properties into the walls of the heart.

Methods and compositions are provided for prophylaxis and treatment of breast cancer involving administration of a therapeutically effective amount of carbetocin and/or other long-acting oxytocin analogues. 1-Butanoic acid-2-(O-methyl-L-tyrosine)-1-carbaoxytocin (carbetocin) and/or other long-acting oxytocin analogues are formulated with a pharmaceutically acceptable carrier and administered in an amount sufficient to inhibit initiation or growth of breast cancer in the patient. The carbetocin and/or other long-acting oxytocin analogues may also be formulated with a pharmaceutically acceptable carrier and administered in an amount sufficient to treat, prevent or alleviate the symptoms of a psychiatric disorder in the patient. Carbetocin may be administered prophylactically or to treat existing conditions in patients by a variety of administration modes, including intramuscular, intravenous, intranasal, intrapulmonary, subcutaneous, parenteral, oral, or transdermal delivery methods and formulations. Preferably, the carbetocin is administered to a mucosal surface of the patient via intranasal delivery. For this purpose, pharmaceutical compositions are provided for intranasal delivery that incorporate carbetocin in a powder or aqueous formulation for intranasal delivery.

The invention provides compositions and methods suitable for ameliorating female sexual dysfunction, and in particular, female sexual arousal disorder. In preferred embodiments, the invention provides a semisolid composition suitable for topical application comprising: an effective amount of a vasoactive prostaglandin, a penetration enhancer, a polymer thickener, a lipophilic component, and an acidic buffer system. In other embodiments, the invention provides a method of treating female sexual arousal disorder by applying an effective dose of a topical semisolid prostaglandin composition to the anterior wall of the vagina.

A urinary catheter with an improved retaining and activating feature is provided which is a safe device with reduced irritation and discomfort to a patient. The retaining mechanism positioned at the proximal end of the catheter assumes a “close” state for introduction and removal of the catheter into and from the urethral tract, and is transitioned into the “open” state when the catheter is in the bladder by mechanically manipulating the retaining mechanism through the activation mechanism. An actuating linkage wire connected between the retaining mechanism and activation mechanism controllably reciprocates in the channel of the catheter to transition the catheter between the “open” and “closed” states.

The invention is a strap-based suspension exercise system that includes a main strap that is attached to a fixed or stationary object to anchor the exercise system and exercise straps that are used to perform a variety of exercises. Different main straps are provided that enable anchoring the exercise system virtually anywhere. The exercise straps, which may be inelastic or elastic are attached to the main strap using a uniquely designed buckle and include a safety strap. Various optional equipment, such as a foot hammock, a wrist or foot strap, additional handles, exercise straps with gym rings, and a vest worn by the user are provided.

A probe for a dermal phase meter includes a handle with an extension that terminates with a displaceable center conductor. A replaceable tip attaches to the distal end of the extension and includes a center conductor that engages the center conductor in the extension and an outer conductor that establishes electrical connection through the extension. Substituting different replacement tips provides a probe with an articulation capability. Probe tips with a layer of a patient compatible, compressible elastomer overmolded onto the outer conductor provides insulation and minimizes the potential for irritating tissues during a measurement in an anatomical cavity.

The intervertebral disc is avascular. With aging, calcified layers occlude the cartilaginous endplates, blocking the diffusion of nutrients and oxygen into the avascular disc. Under anaerobic condition, excessive production of lactic acid irritates nerves and further hinders transport of sodium sulfate essential for biosynthesis of the water retaining and load sustaining sulfated glycosaminoglycans. As the result of acid irritation and load shifting to facet joints, pain ensues. Through the pedicle, calcified endplate is punctured by a well-supported and elastically curved needle, injecting antacid to neutralize the lactic acid and enhance transport of sodium sulfate into the shielded discs between ilia. Disc filler or nutrients can also be injected through the curved needle into the degenerated disc.

The present invention discloses a method for treating or preventing a bone disorder in a mammal in need thereof comprising orally administering to said mammal a pharmaceutically effective amount of a pharmaceutical composition of at least one bisphosphonate, or a pharmaceutically acceptable salt or esters thereof, and at least one aminoalky methacrylate copolymer, according to a dosing schedule having a dosing interval selected from once-weekly dosing, twice-monthly dosing, once-monthly, once-quarterly and once-annually dosing. The present invention further discloses a method for treating or preventing a bone disorder in a mammal in need thereof comprising continuously orally administering a unit dosage per-day to said mammal in a short time for a long time therapy.

An apparatus for enabling provision of one or more policies to manage behavior of one or more communications devices may include a processor and memory storing executable computer code causing the apparatus to at least perform operations including analyzing data of at least one policy. The policy includes information instructing a communication device(s) regarding a manner to behave according to a designated network condition(s) designated by a network operator. The computer program code may further cause the apparatus to apply the policy responsive to detecting a load of a network is increased or that the network is congested. The computer program code may further cause the apparatus to behave in the manner designated by the network operator according to the applied policy responsive to detecting the increased load or that the network is congested to minimize congestion in the network. Corresponding methods and computer program products are also provided.