40results about How to "Give full play to the antibacterial effect" patented technology

The invention belongs to the field of veterinary medicine, and particularly relates to amoxicillin or amoxicillin and clavulanate potassium instant chewable tablets for pet and a preparation method for the same. The instant chewable tablets are the amoxicillin or amoxicillin and clavulanate potassium instant chewable tablets prepared by combining with orally disintegrating tablets fast in medicine release speed in oral cavity and bad in disintegrating crispness and chewable tablets chewable but slow in disintegrating and medicine release speeds on the basis of the present dosage form of amoxicillin or amoxicillin and clavulanate potassium, so that administration for pet is greatly facilitated, and the antibacterial characteristic of amoxicillin can be adequately exerted. The preparation method for the instant chewable tablets comprises the following steps of: crushing amoxicillin or amoxicillin and clavulanate potassium and related auxiliary materials, and passing through a sieve of 50-100 meshes at first; uniformly mixing the main medicine and the selected auxiliary materials in a proper ratio, and producing wet granules; and drying and straightening the granules, and then tabletting. The instant chewable tablets have broad-spectrum antimicrobial activity and can be used for preventing and treating the bacterial infection of pet. While being used, the preparation is placed in the mouth of pet and fast melted by chewing, so that the convenience and compliance of administration for pet are solved well.

The invention relates to an environment-friendly nano-silver bacteriostatic compound, and belongs to the technical field of antibacterial agents. Nano-copper powder as a raw material cooperates with epoxy resin to be used as a bacteriostatic carrier, the bacteriostatic effect can be fully played and good biodegradability is achieved; with sodium alginate as a reducing agent and a stabilizing agent, an AgNO3 solution is irradiated by ultraviolet light to prepare the nano-silver and silver compound, so the compound gives full play to a bacteriostatic effect, and has high biodegradability; addedmicrocrystalline paraffin wax can carry nano-silver in the system to float upward to the surface of the system during preparation, a water-inhibiting bacteriostatic layer is formed on the product surface, and the plasticity of the bacteriostatic compound system can be improved; in the subsequent preparation process, plant essential oil can occupy the positions of a part of functional groups in thecross-linking network of a composite matrix and chitosan, reduces the vibration intensity of covalent bonds in the cross-linking network molecules, plays a multi-level bacteriostatic effect, and hasno secondary pollution. The problems that the commonly used bacteriostatic agent can cause secondary pollution and has poor bacteriostatic effect in the use process are solved.

The invention provides a preparation method of a Ag / TiO2 whisker-medical polyurethane composite material. The preparation method is characterized by comprising the following steps of: a, preparing 0.01-1M silver-salt solution, adding a positive-hole trapping agent and removing oxygen in a reaction system; b, adding TiO2 whiskers into the reaction system according to the mass ratio of silver to TiO2 of (1:1)-(1:50) in the silver-salt solution, stirring and adsorbing for 0.5-8h; c, under the stirring and anaerobic conditions, adopting a photochemical reduction method to reduce silver ions so asto prepare silver particles on the surfaces of the TiO2 whiskers; d, after the reaction is finished, filtering, obtaining the TiO2 whiskers carrying the silver particles, drying the TiO2 whiskers under the vacuum condition till the weight is constant, and storing for spare use; e, under room temperature, preparing polyurethane solution according to the proportion of the medical polyurethane to anorganic solvent of (1:3)-(1:30); and f, adding the Ag / TiO2 whiskers obtained in the step d into the medical polyurethane solution obtained in the step e, fully stirring to lead the Ag / TiO2 whiskers to be distributed uniformly in the medical polyurethane solution, then adopting a solvent volatilization method to prepare a polyurethane film with uniformly-dispersed Ag / TiO2 whiskers, drying the polyurethane film under the vacuum condition till the weight is constant, and storing for spare use. The Ag particles are prepared by the photo-reduction method, and the Ag particles carried by the Ag / TiO2 whiskers are not easy to fall, so that the possible biotoxicity possible to exist in the nano silver particles can be reduced furthest.

The invention discloses graphene lubricating oil and a preparation method thereof. The graphene lubricating oil is prepared from the following raw materials: engine oil, rice bran oil, ethylene glycoldipolynaphthenate, cyclohexane, triethanolamine, a silane coupling agent KH-570, octylphenol, 4-hydroxyl-4-methyl-2-pentanone, styrenated phenol, jojoba oil, alkenyl succinate, castor oil polyoxyethylene ether, benzotriazole, cinnamyl alcohol, secondary octanol, polyoxyethylene glyceryl ether laurate, methylisothiazolinone, uracil, carbon black, wax powder, corundum powder, nano silicon dioxide,stearic acid, pentaerythritol, naphthenic acid, ammonium bicarbonate, zinc acetylacetonate, nano graphene, aluminum nitride and an antibacterial agent; the graphene lubricating oil is prepared throughsteps of preparing a base material, preparing a modified material, mixing and the like. The graphene lubricating oil provided by the invention has excellent high-temperature resisting, antirust and antibacterial performance.

The invention discloses a long-acting antibacterial agent. The long-acting antibacterial agent is prepared by the following steps: 1) preparing polyurethane aerogel, 2) preparing a nano silicon dioxide polyurethane aerogel composite carrier, and 3) preparing the antibacterial agent. According to the long-acting antibacterial agent disclosed by the invention, titanium dioxide is loaded in the silicon dioxide hollow microspheres, so that the defect of poor stability of titanium dioxide can be effectively overcome, titanium dioxide is slowly diffused to the outside, the antibacterial time efficiency of the long-acting antibacterial agent can be improved, and the utilization rate of titanium dioxide is increased. The nano titanium dioxide-nano silicon dioxide compound is stably adsorbed by utilizing the characteristics of high specific surface area and high porosity of the polyurethane aerogel, and agglomeration of the nano titanium dioxide-nano silicon dioxide compound can be prevented, so that the antibacterial effect of the nano titanium dioxide can be fully exerted, and finally, excellent antibacterial performance is obtained. The long-acting antibacterial agent disclosed by the invention can be applied to preparation of materials such as coatings or films with antibacterial properties, and has a very good market application prospect.

A monoglyceride laurate microemulsion used for antiseptic and antimildew purpose of food and cosmetics is prepared from surfactant, surfactant aid, monoglyceride laurate, and wate or sodium chloride or weak organic acid through proportioning, mixing the first three, heating to 45-80 deg.C while stirring for fully fusing, and slowly adding other until the liquid mixture becomes clear.

The invention discloses nano polypeptide hydrogel of composite stem cell spheres as well as a preparation method and application of the nano polypeptide hydrogel. The preparation method comprises the following steps: (a) preparing the stem cell spheres; (b) preparing the self-assembled polypeptide hydrogel; and (c) compounding of the stem cell spheres and the self-assembled polypeptide hydrogel: inoculating the stem cell spheres into the self-assembled hydrogel to obtain the nano polypeptide hydrogel compounded with the stem cell spheres. According to the invention, the human umbilical cord mesenchymal stem cell spheres and the nano-polypeptide hydrogel are combined and can be directly smeared on a skin wound, so that the survival of transplanted cells is greatly improved, the pain in the transplanting process is relieved, and the operative wound is avoided; the transplanted stem cells gradually disappear after wound healing, and the method is more convenient, safer and more efficient.

The invention discloses a compound ketoconazole lotion for hair. The compound ketoconazole lotion comprises, by weight, 1-2% of ketoconazole, 0.02-0.03% of clobetasol propionate, 20-26.5% of surfactant, 3-7% of cosurfactant, 0.2-0.5% of conditioner, 6-10% of foaming agent, 0.05-0.15% of ethylenediamine tetraacetic acid disodium salt, 0.5-3% of antioxidant, 0.01-0.03% of pigment and the balance purified water. Accessories used in the compound ketoconazole lotion for hair include the surfactant, the cosurfactant, the conditioner, the foaming agent, the antioxidant and the ethylenediamine tetraacetic acid disodium salt serving as the antioxidant synergist, the stabilizer and the softener. A proper number of accessories are matched with the ketoconazole and the clobetasol propionate so that the characters and the performance of the compound ketoconazole lotion for hair can be stable, the antibacterial activity of the ketoconazole and the clobetasol propionate can be brought into full play, in addition, compound ketoconazole lotion does not contain silicone oil or essence, the hair quality can be well conditioned, and the hair follicles cannot be damaged.

The invention provides an essential oil sustained-release antibacterial capsule with bagasse as a wall material and a preparation method thereof, belonging to the technical field of food manufacturing. Bagasse is used as the wall material, plant essential oil is used as the core material, and it is prepared by co-precipitation method; the core-to-wall ratio is 1:1-10, and then the prepared capsules are added to the chitosan solution, then TPP solution, and centrifuged The essential oil sustained-release antibacterial capsule is obtained; the mass concentration of the chitosan solution is 0.2-0.5%, and the mass concentration of the TPP solution is 0.2-0.5%. The sustained-release antibacterial capsule is prepared by using bagasse as the wall material and plant essential oil as the core material, which fully exerts the antibacterial effect of the plant essential oil, and fully utilizes the bagasse to utilize waste, thereby reducing waste of resources and alleviating environmental pressure.

The invention discloses a method for improving pig lysozyme by fusing an N-terminal with an HLH functional domain, and belongs to the field of bioengineering. The method comprises the steps of design of a fused pig lysozyme gene and expression and renaturation of an escherichia coli expression system. By means of detection of antibacterial activity, the fused pig lysozyme has obvious resistance to gram-positive bacteria and can kill various gram-positive bacteria simultaneously, and an excellent case is provided for improving the antibacterial activity of the lysozyme. The fused pig lysozyme preparation technology has the advantages of being simple and efficient, the product can reach electrophoretic purity, and the purity is 90% or above.

The invention discloses a silver-containing nanometer composite antibacterial coating and a preparation method thereof. The preparation method comprises: synthesizing a maleic acid mono-fatty alcoholester sodium salt methyl methacrylate by using polyacrylate and polymethyl methacrylate as a polyacrylate copolymerization matrixes, wherein the methyl methacrylate used as both a polymerizable emulsifier and an auxiliary comonomer regulates the dispersion of Ag nanoparticles in the polymer matrix through electrostatic interaction and steric hindrance interaction; preparing a nanometer composite emulsion through semi-continuous emulsion polymerization; preparing a nanometer composite coating by using butyl acrylate and polymethyl methacrylate as the main components of the coating through an emulsion polymerization method; and dispersing Ag nanoparticles in the polymer matrix to prepare the high-dispersion nanometer composite antibacterial coating.