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Compound ketoconazole lotion for hair

A technology of compound ketoconazole and ketoconazole, which is applied in anti-inflammatory agents, pharmaceutical formulations, hair care, etc., can solve problems such as hair follicle damage, and achieve the effect of improving hair quality, stable performance, and stable properties

Inactive Publication Date: 2015-09-30
JIANGSU LINGBAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In order to maintain the stability of the lotion and improve the hair quality of the existing ketoconazole hair lotion, it is necessary to add silicone oil to the lotion, but the silicone oil has certain damage to the hair follicle

Method used

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  • Compound ketoconazole lotion for hair
  • Compound ketoconazole lotion for hair
  • Compound ketoconazole lotion for hair

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Add purified water into a clean emulsification pot, start stirring and heat to 80-85°C, then add 170g of alkyl glucoside, 90g of ammonium lauryl sulfate, 30g of cocoamidopropyl betaine, and 30g of cocoyl monoethanolamide Stir to dissolve, then add 15g of ketoconazole and 0.25g of clobetasol propionate in propylene glycol, rinse the raw material dissolving pot with propylene glycol, add the rinse solution into the emulsification pot, start stirring, and homogenize for 10 minutes.

[0025] Pour 4.5g of cationic guar gum and 1g of disodium edetate solution dissolved in purified water into the emulsification pot, start stirring, and homogenize for 10 minutes. Then, when the material in the emulsification pot is cooled to 45°C, add 0.2g of pigment and 15g of sodium bisulfite aqueous solution into the emulsification pot through the feeding port, stir for 10 minutes, continue cooling, and cool to room temperature.

[0026] Wherein, the total consumption of purified water is 61...

Embodiment 2

[0028] Add purified water into a clean emulsification pot, start stirring and heat to 80-85°C, then add 160g of alkyl glucoside, 60g of ammonium lauryl sulfate, 20g of cocoamidopropyl betaine, and 20g of cocoyl monoethanolamide Stir to dissolve, then add 15g of ketoconazole and 0.25g of clobetasol propionate in propylene glycol, rinse the raw material dissolving pot with propylene glycol, add the rinse solution into the emulsification pot, start stirring, and homogenize for 10 minutes.

[0029] Pour 2 g of cationic guar gum and 0.5 g of disodium edetate solution dissolved in purified water into the emulsification pot, start stirring, and homogenize for 10 minutes. Then when the material in the emulsification pot is cooled to 45°C, add 0.1g of pigment and 5g of sodium bisulfite aqueous solution into the emulsification pot through the feeding port, stir for 10 minutes, continue cooling, and cool to room temperature.

[0030] Wherein, the total consumption of purified water is 66...

Embodiment 3

[0032] Add purified water into a clean emulsification pot, start stirring and heat to 80-85°C, then add 180g of alkyl glucoside, 100g of ammonium lauryl sulfate, 40g of cocoamidopropyl betaine, and 45g of cocoyl monoethanolamide Stir to dissolve, then add 15g of ketoconazole and 0.25g of clobetasol propionate in propylene glycol, rinse the raw material dissolving pot with propylene glycol, add the rinse solution into the emulsification pot, start stirring, and homogenize for 10 minutes.

[0033] Pour 5 g of cationic guar gum and 1.5 g of disodium edetate solution dissolved in purified water into the emulsification pot, start stirring, and homogenize for 10 minutes. Then, when the material in the emulsification pot is cooled to 45°C, add 0.3g of pigment and 30g of sodium bisulfite aqueous solution into the emulsification pot through the feeding port, stir for 10 minutes, continue cooling, and cool to room temperature.

[0034] Wherein, the total consumption of purified water is...

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Abstract

The invention discloses a compound ketoconazole lotion for hair. The compound ketoconazole lotion comprises, by weight, 1-2% of ketoconazole, 0.02-0.03% of clobetasol propionate, 20-26.5% of surfactant, 3-7% of cosurfactant, 0.2-0.5% of conditioner, 6-10% of foaming agent, 0.05-0.15% of ethylenediamine tetraacetic acid disodium salt, 0.5-3% of antioxidant, 0.01-0.03% of pigment and the balance purified water. Accessories used in the compound ketoconazole lotion for hair include the surfactant, the cosurfactant, the conditioner, the foaming agent, the antioxidant and the ethylenediamine tetraacetic acid disodium salt serving as the antioxidant synergist, the stabilizer and the softener. A proper number of accessories are matched with the ketoconazole and the clobetasol propionate so that the characters and the performance of the compound ketoconazole lotion for hair can be stable, the antibacterial activity of the ketoconazole and the clobetasol propionate can be brought into full play, in addition, compound ketoconazole lotion does not contain silicone oil or essence, the hair quality can be well conditioned, and the hair follicles cannot be damaged.

Description

technical field [0001] The present invention relates to a hair lotion, more specifically to a compound ketoconazole hair lotion. Background technique [0002] The scalp is the soft tissue covering the skull. A healthy scalp ecological environment is maintained by three major balances: oil, bacteria, and metabolic balance. When the oil secretion of the scalp is unbalanced, the scalp will become oily; when the environment of the scalp flora is unbalanced, harmful bacteria will multiply, and itchiness will appear; and the metabolism of the scalp cuticle is too fast, and dandruff will form when it falls off. Ketoconazole hair lotion can maintain the balance of oil, flora and metabolism to ensure the health of the scalp. In order to maintain the stability of the lotion and improve the hair quality of the existing ketoconazole hair lotion, it is necessary to add silicone oil to the lotion, but the silicone oil has certain damage to the hair follicle. Contents of the invention ...

Claims

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Application Information

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IPC IPC(8): A61K8/63A61K8/49A61Q5/02A61P31/10A61P29/00A61P17/04A61P37/08
Inventor 王德才
Owner JIANGSU LINGBAO PHARMA
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