34results about How to "Inhibit necrosis" patented technology

The invention relates to a compound 11-deoxy-18 alpha glycyrrhetinic acid derivative in a formula II, and application thereof in the fields of hepatic injury treatment, anti-inflammatory and the like. The invention relates to a preparation method of the glycyrrhetinic acid ester derivative.

The invention discloses a combined medicine for treating acute viral hepatitis, which comprises the following raw materials in parts by weight: 0.01-0.02 parts of adefovir, 15-20 parts of rhubarb, 15-20 parts of licorice, and 15-20 parts of forsythia 20 parts, 15‑20 parts of Atractylodes macrocephala, 15‑20 parts of Desmodium, 15‑20 parts of Banzhilian, 15‑20 parts of Curcuma, 15‑20 parts of raspberry, 15‑20 parts of corn silk. The preparation method of the combined medicine is as follows: firstly, the raw medicinal material is extracted with 10 times the weight of 80% ethanol under reflux, extracted for 2 hours, filtered, the dregs are retained, the ethanol extract is collected, and the ethanol is recovered under reduced pressure, and then further concentrated to a thick paste , vacuum or microwave drying to obtain a dry extract; then add 8 times the weight of water to the dregs to decoct and extract twice, each time for 1.5 to 2 hours, filter, combine the water extracts, concentrate under reduced pressure to a thick paste, vacuum or Microwave drying to obtain dry extracts; combine the obtained extracts, crush them, add adefovir, and then add starch or dextrin to mix evenly, make tablets, granules or capsules, and pack them separately.

The invention relates to the field of biotechnology and aims at providing an application of AIF1 (Allograft Inflammatory Factor 1) protein and antibody to preparing a southern oyster anti-infectious immune preparation. The amino acid sequence of the protein is shown in SEQ ID NO.2; the open reading frame nucleotide sequence of the protein is shown in SEQ ID NO.1; and the application of the protein to preparing the southern oyster anti-infectious immune preparation is as follows: immunizing a New Zealand white rabbit by use of the protein so as to obtain polyclonal antiserum. According to the invention, the open reading frame complete sequence of a southern oyster AIF1 gene is obtained; and by virtue of constructing a prokaryotic expression vector, a soluble AIF1 protein product is expressed and purified, and the polyclonal antiserum is prepared; and the polyclonal antiserum has an effect of restraining inflammatory reactions caused by a southern oyster pathogeny RLO (Rickettsia-Like Organism) and gram-negative bacterium LPS (Lipopolysaccharide), as well as cytoclasis and apoptosis.

The invention provides a dipeptide derivative for improving liver function, and its application, specifically an N-substituted 2(1H) dipeptide derivative and its pharmaceutically acceptable salt, and pharmaceutical composition containing the compound. The compound can effectively improve liver function, to lower alanine aminotransferase (ALT), aspartate aminotransferase (AST) and / or total bilirubin (Tbil). The compound can greatly improve survival rate of liver failure patient.